Protein Alignment Hn and TPH1

DIOPT Version :9

• Sequence 1: NP_001261542.1
• Gene: Hn / 38871
• FlyBaseID: FBgn0001208
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_004170.1
• Gene: TPH1 / 7166
• HGNCID: 12008
• Length: 444
• Species: Homo sapiens
• Alignment Length: 431
• Identity: 232/431 - (53%)
• Similarity: 312/431 - (72%)
• Gaps: 14/431 - (3%)

  Fly    28 EARNTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESRSSLRVPG-YEFFVEADGKSGALGK 91
            |.....|:||.|:   ..|.|...|.||::..:||:|||||.|.|... :|.||:.|.....|..
Human    14 ERGRASLIFSLKN---EVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLND 75

  Fly    92 AIEDVKEQCSYFNIISRDYKDNAT-------AVPWFPRRIRDLDRFANQILSYGSELDADHPGFT 149
            ....:|   |:.|::|.:..||.|       .|||||::|.|||..||::|.||||||||||||.
Human    76 IFHLLK---SHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFK 137

  Fly   150 DPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYNHVFPLLVD 214
            |..||||||||||:|.|||||:|:|.|::|:|||:|||.:|:.|.|||.|||||||....|||..
Human   138 DNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSK 202

  Fly   215 NCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPMYTPE 279
            .||:|||||||||||||||::.|||::|||||.||.||||:||||||||.|||:||.|.|.||||
Human   203 YCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPE 267

  Fly   280 PDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQEGELKAYGA 344
            ||.||||:|||||.|:|:|||||||||||||||.::.::||:|.::||||:|:|:|:|:|:.:||
Human   268 PDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGA 332

  Fly   345 GLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKFANSIPRPF 409
            |||||..||::.|:...::|.|:|::|...:..||.||.:|:|::|||.||||..:|..:|.|||
Human   333 GLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPF 397

  Fly   410 GVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKL 450
            ||:||.||:|:::|.....|::.|:.:..:..::.:|:||:
Human   398 GVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKV 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hn	NP_001261542.1	Phe4hydrox_tetr	15..451	CDD:130335	232/431 (54%)
		ACT_AAAH	32..107	CDD:153176	26/75 (35%)
		Biopterin_H	118..447	CDD:278766	197/328 (60%)
TPH1	NP_004170.1	Trp_5_monoox	3..439	CDD:130337	232/431 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	40	1.000	Domainoid score	I12535
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54212
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820