DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hn and tph2

DIOPT Version :9

Sequence 1:	NP_001261542.1	Gene:	Hn / 38871	FlyBaseID:	FBgn0001208	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001296997.1	Gene:	tph2 / 407712	ZFINID:	ZDB-GENE-040624-4	Length:	546	Species:	Danio rerio

Alignment Length:	474	Identity:	231/474 - (48%)
Similarity:	322/474 - (67%)	Gaps:	42/474 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RQVSFDKPTRVEDSAYIVEGVDIKEARNT------CLLFSPKDSSLSSGALANILAIFKKHDINL 62
            |:.||::         |.|..|.:|.::|      .::||.|:   ..|.|...|.:|::..:||
Zfish    82 RRTSFNR---------IDERPDKEEQKSTHDLGKLAVIFSLKN---EVGFLVKALRLFQEKHVNL 134

  Fly    63 VHIESRSSLRVPG-YEFFVEADGKSGALGKAIEDVKEQCSYFNIIS-----------RDYKD--- 112
            .|||||.|.|:.. .|.:.|.:.......:.::.:|:   :.||:|           .|..|
Zfish   135 AHIESRRSKRLTNEIEIYAECNCTKKEFNELVQHLKD---HVNIVSYNTPQHVWSAETDCLDCVC 196

  Fly   113 ------NATAVPWFPRRIRDLDRFANQILSYGSELDADHPGFTDPEYRKRRKYFADIAYNYKHGE 171
                  :...:||||::|.:||:.::::|.||||||||||||.|..||:|||||.::|.|||.|:
Zfish   197 VLGGLPDGEGIPWFPQKISELDQCSHRVLMYGSELDADHPGFKDKVYRQRRKYFVEVAMNYKFGQ 261

  Fly   172 PLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYNHVFPLLVDNCGFREDNIPQLEDVSNFLRDC 236
            |:|.::||.||::|||:::|.|||||.|||||||....|||..:||:||||||||||||.|||:.
Zfish   262 PIPRIEYTAEEVKTWGVVYRELTKLYPTHACREYLKNLPLLTKHCGYREDNIPQLEDVSLFLRER 326

  Fly   237 TGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPMYTPEPDVCHELMGHVPLFADPAFAQF 301
            :|||:|||||.||.||||||||:|||:.||||||.:.|:||||||.||||:|||||.|||.||||
Zfish   327 SGFTVRPVAGYLSPRDFLAGLAYRVFNCTQYIRHSTDPLYTPEPDTCHELLGHVPLLADPKFAQF 391

  Fly   302 SQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQEGELKAYGAGLLSSYGELEYCLTDKPQLKDF 366
            |||||||||||.|:.::||:|.::||:|:|:|:|:|:|:.||||||||.|||.:.|:||..:|.|
Zfish   392 SQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQDGQLRVYGAGLLSSIGELRHALSDKATVKVF 456

  Fly   367 EPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKFANSIPRPFGVRYNAYTQSVEVLDSKPQISN 431
            :|:.|...:..||.||.:|:|::|||.||||..:||.||.|||.|.||.||||:::|.....|.|
Zfish   457 DPKTTCYQECLITTFQDVYFVSESFEEAKEKMREFAKSIKRPFSVYYNPYTQSIDLLKDTRSIEN 521

  Fly   432 LMDNINSEFQILQNAVAKL 450
            ::.::.|:...:.:|:.|:
Zfish   522 VVQDLRSDLTTVCDALGKM 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hn	NP_001261542.1	Phe4hydrox_tetr	15..451	CDD:130335	228/463 (49%)
		ACT_AAAH	32..107	CDD:153176	22/81 (27%)
		Biopterin_H	118..447	CDD:278766	197/328 (60%)
tph2	NP_001296997.1	Trp_5_monoox	84..541	CDD:130337	230/472 (49%)
		ACT_TPH	108..180	CDD:153201	22/77 (29%)
		Biopterin_H	208..537	CDD:278766	197/328 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54212
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720