DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hn and pah

DIOPT Version :9

Sequence 1:	NP_001261542.1	Gene:	Hn / 38871	FlyBaseID:	FBgn0001208	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_956845.1	Gene:	pah / 378962	ZFINID:	ZDB-GENE-031006-2	Length:	449	Species:	Danio rerio

Alignment Length:	438	Identity:	281/438 - (64%)
Similarity:	343/438 - (78%)	Gaps:	12/438 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SAYIVEGVDIKEARNTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESRSSLR-VPGYEFFV 80
            |:|:.|.:: |....:| :||.|:   ..|||...|.:|::..|||.|||||.|.: ...||||:
Zfish    20 SSYLEEPLN-KSGVVSC-IFSLKE---EVGALVEALKLFEEKGINLTHIESRPSRKNNEEYEFFI 79

  Fly    81 EAD-GKSGALGKAIEDVKEQC-SYFNIISRD-YKDNATAVPWFPRRIRDLDRFANQILSYGSELD 142
            ..| ..|..|.:.::.::.|. ...:.:||: .||   .|||||..|:|||||||||||||||||
Zfish    80 SVDQASSKVLDEIVDGLRTQIRGQVHELSRNKQKD---TVPWFPNDIQDLDRFANQILSYGSELD 141

  Fly   143 ADHPGFTDPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYNH 207
            ||||||||..||.|||.||||||||:||:|:|.|:||.||..|||.:||.|..||.||||||:|.
Zfish   142 ADHPGFTDTVYRARRKEFADIAYNYRHGQPIPRVEYTAEEKATWGTVFRELKTLYPTHACREHNR 206

  Fly   208 VFPLLVDNCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPS 272
            |||||...||:||||||||||:|::|:.||||.||||||||||||||||||||||||||||||.|
Zfish   207 VFPLLEKYCGYREDNIPQLEDISHYLQSCTGFRLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHSS 271

  Fly   273 KPMYTPEPDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQEG 337
            |||||||||:||||:|||||||||.|||||||||||||||||::||||:|::|||||:|:|:|..
Zfish   272 KPMYTPEPDICHELLGHVPLFADPNFAQFSQEIGLASLGAPDEFIEKLATVYWFTVEFGLCKQGN 336

  Fly   338 ELKAYGAGLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKFA 402
            |:||||||||||:|||:||||::|:|:.||||.|...|||||:|||:|:||:|||.||||..:||
Zfish   337 EVKAYGAGLLSSFGELQYCLTNEPKLQPFEPEKTCQQKYPITEFQPVYFVAESFEDAKEKVRRFA 401

  Fly   403 NSIPRPFGVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKL 450
            .:|||||.||||||||.:|:||:..|:.||.|:||.|..||.||:.|:
Zfish   402 TTIPRPFSVRYNAYTQRIEMLDNAQQLKNLADSINGEISILCNALRKM 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hn	NP_001261542.1	Phe4hydrox_tetr	15..451	CDD:130335	281/438 (64%)
		ACT_AAAH	32..107	CDD:153176	26/77 (34%)
		Biopterin_H	118..447	CDD:278766	244/328 (74%)
pah	NP_956845.1	ACT_PAH	19..108	CDD:153203	30/92 (33%)
		Phe4hydrox_tetr	20..449	CDD:130335	280/436 (64%)
		Biopterin_H	117..447	CDD:278766	245/329 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581374
Domainoid	1	1.000	529	1.000	Domainoid score	I274
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H234
Inparanoid	1	1.050	559	1.000	Inparanoid score	I1065
OMA	1	1.010	-	-		QHG54212
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		oto39449
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	1	1.100	-	-	LDO	PTHR11473
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3415
SonicParanoid	1	1.000	-	-		X6360
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790