Protein Alignment Hn and tph1a

DIOPT Version :10

• Sequence 1: NP_523963.2
• Gene: Hn / 38871
• FlyBaseID: FBgn0001208
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_840091.2
• Gene: tph1a / 352943
• ZFINID: ZDB-GENE-030317-1
• Length: 483
• Species: Danio rerio
• Alignment Length: 454
• Identity: 238/454 - (52%)
• Similarity: 322/454 - (70%)
• Gaps: 24/454 - (5%)

  Fly     5 QVSFDKPTRVEDSAYIVEGVDIKEARNTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESRS 69
            ::..:|..:.|.|          |.....::||.|:   ..|.|...|.:|:::.:||||||||.
Zfish    40 KIEENKDNKTESS----------ETGRAAVVFSLKN---EVGGLVKALKLFQENHVNLVHIESRK 91

  Fly    70 SLRVPG-YEFFVEADGKSGALGKAIEDVKEQCSYFNIISRDYKDNATA-------VPWFPRRIRD 126
            |.|... :|.||:.|.....|.:.|:.:::   :.|::..|..||...       |||||::|.|
Zfish    92 SKRRNSEFEIFVDCDSNREQLHEIIQLLRK---HVNVVEMDAPDNRLPEESEMENVPWFPKKISD 153

  Fly   127 LDRFANQILSYGSELDADHPGFTDPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFR 191
            ||:.||::|.|||:||||||||.|..||||||||||:|.:||||:|:|.:::|:||::|||::||
Zfish   154 LDKCANRVLMYGSDLDADHPGFKDNVYRKRRKYFADLAMSYKHGDPIPRIEFTEEEVKTWGVVFR 218

  Fly   192 NLTKLYKTHACREYNHVFPLLVDNCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAG 256
            .|.|||.:||||||....|||:.:|..||||||||||||.||::.||||:|||||.||.||||||
Zfish   219 ELNKLYPSHACREYLKNLPLLIKHCDSREDNIPQLEDVSRFLKERTGFTIRPVAGYLSPRDFLAG 283

  Fly   257 LAFRVFHSTQYIRHPSKPMYTPEPDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLS 321
            |||||||.|||:||.|.|:||||||.||||:|||||.|:|:|||||||||||||||.||.|:||:
Zfish   284 LAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASDDSIQKLA 348

  Fly   322 TIFWFTVEYGVCRQEGELKAYGAGLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYY 386
            |.::||||:|:|:|||:|:|||||||||..||::.|:...::..|:|.||...:..||.||.:|:
Zfish   349 TCYFFTVEFGLCKQEGKLRAYGAGLLSSISELKHALSGNARILPFDPNVTCKQECIITTFQDVYF 413

  Fly   387 VADSFETAKEKTIKFANSIPRPFGVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKL 450
            ::||||.||.|..:||.:|.|||.||||.|||||:||.....|:|:::.:..|..|:.:|:::|
Zfish   414 MSDSFEEAKVKMREFAKTIKRPFSVRYNPYTQSVDVLKDTTSINNVVEELRHELDIIGDALSRL 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hn	NP_523963.2	Phe4hydrox_tetr	15..451	CDD:130335	237/444 (53%)
tph1a	NP_840091.2	Trp_5_monoox	50..478	CDD:130337	237/444 (53%)