DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hn and Tph1

DIOPT Version :9

Sequence 1:	NP_001261542.1	Gene:	Hn / 38871	FlyBaseID:	FBgn0001208	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001094104.1	Gene:	Tph1 / 24848	RGDID:	3895	Length:	444	Species:	Rattus norvegicus

Alignment Length:	443	Identity:	232/443 - (52%)
Similarity:	316/443 - (71%)	Gaps:	12/443 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VEDSAYIVEGVDIKEAR-NTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESRSSLRVPG-Y 76
            :||:.   |..|....| ...|:||.|:   ..|.|...|.||:::.:||:|||||.|.|... :
  Rat     2 IEDNK---ENKDHSSERGRVTLIFSLKN---EVGGLIKALKIFQENHVNLLHIESRKSKRRNSEF 60

  Fly    77 EFFVEADGKSGALGKAIEDVKEQCSYFNIISRDY----KDNATAVPWFPRRIRDLDRFANQILSY 137
            |.||:.|.....|......:|...:..::.|.|.    :|....|||||::|.|||..||::|.|
  Rat    61 EIFVDCDINREQLNDIFPLLKSHTTVLSVDSPDQLPEKEDVMETVPWFPKKISDLDFCANRVLLY 125

  Fly   138 GSELDADHPGFTDPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHAC 202
            |||||||||||.|..||:||||||::|.|||||:|:|.:::|:|||:|||.|||.|.|||.||||
  Rat   126 GSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHAC 190

  Fly   203 REYNHVFPLLVDNCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQY 267
            |||....|||...||:||||:||||||||||::.|||::|||||.||.||||:||||||||.|||
  Rat   191 REYLRNLPLLSKYCGYREDNVPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQY 255

  Fly   268 IRHPSKPMYTPEPDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGV 332
            :||.|.|:||||||.||||:|||||.|:|:|||||||||||||||.::.::||:|.::||||:|:
  Rat   256 VRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGL 320

  Fly   333 CRQEGELKAYGAGLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEK 397
            |:|:|:|:.:|||||||..||.:.|:...::|.|:|:|....:..||.||.:|:|::|||.||||
  Rat   321 CKQDGQLRVFGAGLLSSISELRHALSGHAKVKPFDPKVACKQECLITSFQDVYFVSESFEDAKEK 385

  Fly   398 TIKFANSIPRPFGVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKL 450
            ..:||.::.|||||:||.||||::||.....|::.|:.:..:..::.:|:|::
  Rat   386 MREFAKTVKRPFGVKYNPYTQSIQVLRDSKSITSAMNELRHDLDVVNDALARV 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hn	NP_001261542.1	Phe4hydrox_tetr	15..451	CDD:130335	232/442 (52%)
		ACT_AAAH	32..107	CDD:153176	24/75 (32%)
		Biopterin_H	118..447	CDD:278766	197/328 (60%)
Tph1	NP_001094104.1	Trp_5_monoox	3..439	CDD:130337	232/442 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54212
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720