DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hn and Pah

DIOPT Version :9

Sequence 1:	NP_001261542.1	Gene:	Hn / 38871	FlyBaseID:	FBgn0001208	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_036751.2	Gene:	Pah / 24616	RGDID:	3248	Length:	453	Species:	Rattus norvegicus

Alignment Length:	440	Identity:	278/440 - (63%)
Similarity:	340/440 - (77%)	Gaps:	10/440 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EDSAYIVEGVDIKEARNTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESR-SSLRVPGYEF 78
            ::::||.:..:...|  ..|:||.|:   ..||||.:|.:|:::||||.||||| |.|....|||
  Rat    20 QETSYIEDNSNQNGA--ISLIFSLKE---EVGALAKVLRLFEENDINLTHIESRPSRLNKDEYEF 79

  Fly    79 FVEADGKS-GALGKAIEDVKEQC-SYFNIISRDYKDNATAVPWFPRRIRDLDRFANQILSYGSEL 141
            |...|.:| ..||..|:.::... :..:.:|||.:.|  .||||||.|::||||||||||||:||
  Rat    80 FTYLDKRSKPVLGSIIKSLRNDIGATVHELSRDKEKN--TVPWFPRTIQELDRFANQILSYGAEL 142

  Fly   142 DADHPGFTDPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYN 206
            |||||||.||.||.|||.||||||||:||:|:|.|:||:||.:|||.:||.|..|||||||.|:|
  Rat   143 DADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYTEEEKQTWGTVFRTLKALYKTHACYEHN 207

  Fly   207 HVFPLLVDNCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHP 271
            |:||||...|||||||||||||||.||:.||||.||||||||||||||.||||||||.||||||.
  Rat   208 HIFPLLEKYCGFREDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHG 272

  Fly   272 SKPMYTPEPDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQE 336
            ||||||||||:||||:||||||:|.:|||||||||||||||||:|||||:||:|||||:|:|::.
  Rat   273 SKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKEG 337

  Fly   337 GELKAYGAGLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKF 401
            ..:||||||||||:|||:|||:|||:|...|.|.....:|.:|:||||||||:||..||||...|
  Rat   338 DSIKAYGAGLLSSFGELQYCLSDKPKLLPLELEKIACQEYSVTEFQPLYYVAESFSDAKEKVRTF 402

  Fly   402 ANSIPRPFGVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKLR 451
            |.:|||||.|||:.|||.|||||:..|:..|.|:||||..||.||:.|::
  Rat   403 AATIPRPFSVRYDPYTQRVEVLDNTQQLKILADSINSEVGILCNALQKIK 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hn	NP_001261542.1	Phe4hydrox_tetr	15..451	CDD:130335	278/438 (63%)
		ACT_AAAH	32..107	CDD:153176	30/77 (39%)
		Biopterin_H	118..447	CDD:278766	238/328 (73%)
Pah	NP_036751.2	Phe4hydrox_tetr	20..452	CDD:130335	278/438 (63%)
		ACT_PAH	21..110	CDD:153203	33/93 (35%)
		Biopterin_H	119..449	CDD:278766	239/329 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341388
Domainoid	1	1.000	514	1.000	Domainoid score	I305
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H234
Inparanoid	1	1.050	555	1.000	Inparanoid score	I1074
OMA	1	1.010	-	-		QHG54212
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		oto96368
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	1	1.100	-	-	LDO	PTHR11473
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6360
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760