DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hn and Th

DIOPT Version :9

Sequence 1:NP_001261542.1 Gene:Hn / 38871 FlyBaseID:FBgn0001208 Length:452 Species:Drosophila melanogaster
Sequence 2:NP_033403.1 Gene:Th / 21823 MGIID:98735 Length:498 Species:Mus musculus


Alignment Length:422 Identity:213/422 - (50%)
Similarity:292/422 - (69%) Gaps:14/422 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 LLFSPKDSSLSSGALANILAIFKKHDINLVHIESRSSLR----VPGYEFFVEADGKSGALGKAIE 94
            ||||.:.:..||  |:..|.:|:..:..:.|:|:|.:.|    .|..|:||..:..||.|...:.
Mouse    85 LLFSLRGTKPSS--LSRALKVFETFEAKIHHLETRPAQRPLAGSPHLEYFVRFEVPSGDLAALLS 147

  Fly    95 DVKEQCSYFNIISRDYKD-NATAVPWFPRRIRDLDRFANQILSYGSELDADHPGFTDPEYRKRRK 158
            .|:.       :|.|.:. ....||||||::.:||:..:.:..:..:||.|||||:|..||:|||
Mouse   148 SVRR-------VSDDVRSAREDKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQAYRQRRK 205

  Fly   159 YFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYNHVFPLLVDNCGFREDNI 223
            ..|:||:.||.|||:|||:||||||.||..::..|..||.||||||:...|.||...||:|||:|
Mouse   206 LIAEIAFQYKQGEPIPHVEYTKEEIATWKEVYATLKGLYATHACREHLEAFQLLERYCGYREDSI 270

  Fly   224 PQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPMYTPEPDVCHELMG 288
            |||||||:||::.|||.|||||||||:|||||.||||||..||||||.|.||::||||.||||:|
Mouse   271 PQLEDVSHFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLG 335

  Fly   289 HVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQEGELKAYGAGLLSSYGEL 353
            |||:.||..||||||:||||||||.|:.||||||::|||||:|:|:|.|||||||||||||||||
Mouse   336 HVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGEL 400

  Fly   354 EYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKFANSIPRPFGVRYNAYTQ 418
            .:.|:::|:::.|:|:...|..|....:||:|:|::||..||:|...:|:.|.|||.|:::.||.
Mouse   401 LHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFSDAKDKLRNYASRIQRPFSVKFDPYTL 465

  Fly   419 SVEVLDSKPQISNLMDNINSEFQILQNAVAKL 450
            :::||||...|...::.:..|...|..|::.:
Mouse   466 AIDVLDSPHTIRRSLEGVQDELHTLTQALSAI 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HnNP_001261542.1 Phe4hydrox_tetr 15..451 CDD:130335 213/422 (50%)
ACT_AAAH 32..107 CDD:153176 21/76 (28%)
Biopterin_H 118..447 CDD:278766 188/328 (57%)
ThNP_033403.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
TOH_N 2..26 CDD:289326
Tyr_3_monoox 38..495 CDD:130336 213/418 (51%)
ACT_TH 38..158 CDD:153202 23/81 (28%)
Biopterin_H 165..495 CDD:278766 189/329 (57%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3186
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000587
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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