Protein Alignment Hn and Tph2

DIOPT Version :10

• Sequence 1: NP_523963.2
• Gene: Hn / 38871
• FlyBaseID: FBgn0001208
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_775567.2
• Gene: Tph2 / 216343
• MGIID: 2651811
• Length: 488
• Species: Mus musculus
• Alignment Length: 435
• Identity: 230/435 - (52%)
• Similarity: 310/435 - (71%)
• Gaps: 16/435 - (3%)

  Fly    25 DIKEARNTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESRSSLRVPG-YEFFVEADGKSGA 88
            |..|:..|.::||.|:   ..|.|...|.:|::..:|::|||||.|.|... .|.||:.:.....
Mouse    55 DTTESSKTAVVFSLKN---EVGGLVKALRLFQEKHVNMLHIESRRSRRRSSEVEIFVDCECGKTE 116

  Fly    89 LGKAIEDVKEQCSYFNI--------ISRDYKDNATAVPWFPRRIRDLDRFANQILSYGSELDADH 145
            ..:.|:.:|.|.:...:        ...|.:|    ||||||:|.:|||.::::|.||:||||||
Mouse   117 FNELIQLLKFQTTIVTLNPPESIWTEEEDLED----VPWFPRKISELDRCSHRVLMYGTELDADH 177

  Fly   146 PGFTDPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYNHVFP 210
            |||.|..||:|||||.|:|..||:|:|:|.|:||:||.:|||::||.|:|||.|||||||....|
Mouse   178 PGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNLP 242

  Fly   211 LLVDNCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPM 275
            ||...||:||||:|||||||.||::.:|||:|||||.||.||||||||:||||.|||:||.|.|:
Mouse   243 LLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYVRHGSDPL 307

  Fly   276 YTPEPDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQEGELK 340
            ||||||.||||:|||||.|||.|||||||||||||||.|:.::||:|.::||:|:|:|:|||:|:
Mouse   308 YTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLR 372

  Fly   341 AYGAGLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKFANSI 405
            |||||||||.|||::.|:||..:|.|:|:.|.:.:..||.||..|:|:||||.||||...||.||
Mouse   373 AYGAGLLSSIGELKHALSDKACVKSFDPKTTCLQECLITTFQDAYFVSDSFEEAKEKMRDFAKSI 437

  Fly   406 PRPFGVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKL 450
            .|||.|.:|.||||:|:|.....|.|::.::.|:...:.:|:.|:
Mouse   438 TRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKM 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hn	NP_523963.2	Phe4hydrox_tetr	15..451	CDD:130335	230/435 (53%)
Tph2	NP_775567.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..60		2/4 (50%)
		ACT_TPH	62..135	CDD:153201	22/75 (29%)
		Biopterin_H	150..480	CDD:459776	202/329 (61%)