DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hn and pah-1

DIOPT Version :9

Sequence 1:	NP_001261542.1	Gene:	Hn / 38871	FlyBaseID:	FBgn0001208	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001254185.1	Gene:	pah-1 / 174401	WormBaseID:	WBGene00000240	Length:	457	Species:	Caenorhabditis elegans

Alignment Length:	443	Identity:	254/443 - (57%)
Similarity:	334/443 - (75%)	Gaps:	19/443 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AYIVE-GVDIKEARNTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESRSSLRVPG-YEFFV 80
            :|:.: ..||.:   |.::|:.::   .:||||..|.:|:.||:||.|||||.|....| ||..|
Worm    18 SYVADVNADIGK---TTIVFTLRE---KAGALAETLKLFQAHDVNLSHIESRPSKTHEGCYEVLV 76

  Fly    81 E-ADGKSGALGKAIEDVKE---QCSYFNIISRDY----KDNATAVPWFPRRIRDLDRFANQILSY 137
            | |:.:.   .:.||.|.|   |.:...::.:|:    |.|..:|||||::|.|:|:|||:||||
Worm    77 EFAEAED---HRKIEGVIEHFQQKAEKKVLVQDWNTKNKQNKDSVPWFPQKINDIDQFANRILSY 138

  Fly   138 GSELDADHPGFTDPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHAC 202
            |:|||||||||.|..||:|||:|||||:|:|||:.:|.:.||.|||.||..::..||.:|..:||
Worm   139 GAELDADHPGFKDMTYRERRKFFADIAFNFKHGDKIPTITYTDEEIATWRTVYNELTVMYPKNAC 203

  Fly   203 REYNHVFPLLVDNCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQY 267
            :|:|::||||..||||..|.||||:|||:||:||||:|:||||||||||||||||||||||||||
Worm   204 QEFNYIFPLLQQNCGFGPDRIPQLQDVSDFLKDCTGYTIRPVAGLLSSRDFLAGLAFRVFHSTQY 268

  Fly   268 IRHPSKPMYTPEPDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGV 332
            |||.|.|.||||||:||||:||||||||..||||||||||||||||||.||||:|::|||:|:|:
Worm   269 IRHHSAPKYTPEPDICHELLGHVPLFADVEFAQFSQEIGLASLGAPDDVIEKLATLYWFTIEFGI 333

  Fly   333 CRQEGELKAYGAGLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEK 397
            |:|:||.||||||||||:|||:|.|:|||::.||:|.|..|||||||::||.|::|:||.:||.|
Worm   334 CQQDGEKKAYGAGLLSSFGELQYALSDKPEVVDFDPAVCCVTKYPITEYQPKYFLAESFASAKNK 398

  Fly   398 TIKFANSIPRPFGVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKL 450
            ...:|.:|.|||.:|||||||.||:||....:..|..:|.|:...|:.|:.|:
Worm   399 LKSWAATINRPFQIRYNAYTQRVEILDKVAALQRLARDIRSDISTLEEALGKV 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hn	NP_001261542.1	Phe4hydrox_tetr	15..451	CDD:130335	254/443 (57%)
		ACT_AAAH	32..107	CDD:153176	29/79 (37%)
		Biopterin_H	118..447	CDD:278766	216/328 (66%)
pah-1	NP_001254185.1	Phe4hydrox_tetr	15..452	CDD:130335	254/443 (57%)
		ACT_AAAH	30..99	CDD:153176	29/74 (39%)
		Biopterin_H	119..448	CDD:278766	216/328 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159584
Domainoid	1	1.000	480	1.000	Domainoid score	I202
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H234
Inparanoid	1	1.050	515	1.000	Inparanoid score	I700
Isobase	1	0.950	-	0	Normalized mean entropy	S2400
OMA	1	1.010	-	-		QHG54212
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	1	1.000	-	-		oto17440
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	1	1.100	-	-	LDO	PTHR11473
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3415
SonicParanoid	1	1.000	-	-		X6360
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.840