DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hn and TPH2

DIOPT Version :10

Sequence 1:NP_523963.2 Gene:Hn / 38871 FlyBaseID:FBgn0001208 Length:452 Species:Drosophila melanogaster
Sequence 2:NP_775489.2 Gene:TPH2 / 121278 HGNCID:20692 Length:490 Species:Homo sapiens


Alignment Length:431 Identity:231/431 - (53%)
Similarity:312/431 - (72%) Gaps:14/431 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 EARNTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESRSSLRVPG-YEFFVEADGKSGALGK 91
            |:..|.::||.|:   ..|.|...|.:|::..:|:||||||.|.|... .|.||:.:.......:
Human    60 ESGKTAVVFSLKN---EVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNE 121

  Fly    92 AIEDVKEQCSYFNIISRDYKDNATA-------VPWFPRRIRDLDRFANQILSYGSELDADHPGFT 149
            .|:.:|.|.:   |::.:..:|...       ||||||:|.:||:.::::|.||||||||||||.
Human   122 LIQLLKFQTT---IVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFK 183

  Fly   150 DPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYNHVFPLLVD 214
            |..||:|||||.|:|..||:|:|:|.|:||:||.:|||::||.|:|||.|||||||...||||..
Human   184 DNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTK 248

  Fly   215 NCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPMYTPE 279
            .||:||||:|||||||.||::.:|||:|||||.||.||||||||:||||.||||||.|.|:||||
Human   249 YCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPE 313

  Fly   280 PDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQEGELKAYGA 344
            ||.||||:|||||.|||.|||||||||||||||.|:.::||:|.::||:|:|:|:|||:|:||||
Human   314 PDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGA 378

  Fly   345 GLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKFANSIPRPF 409
            |||||.|||::.|:||..:|.|:|:.|.:.:..||.||..|:|::|||.||||...||.||.|||
Human   379 GLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPF 443

  Fly   410 GVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKL 450
            .|.:|.||||:|:|.....|.|::.::.|:...:.:|:.|:
Human   444 SVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKM 484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HnNP_523963.2 Phe4hydrox_tetr 15..451 CDD:130335 231/431 (54%)
TPH2NP_775489.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 31..58
ACT 64..137 CDD:471857 24/78 (31%)
Biopterin_H 152..482 CDD:459776 203/329 (62%)
Blue background indicates that the domain is not in the aligned region.

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