DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hn and TPH2

DIOPT Version :9

Sequence 1:	NP_001261542.1	Gene:	Hn / 38871	FlyBaseID:	FBgn0001208	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_775489.2	Gene:	TPH2 / 121278	HGNCID:	20692	Length:	490	Species:	Homo sapiens

Alignment Length:	431	Identity:	231/431 - (53%)
Similarity:	312/431 - (72%)	Gaps:	14/431 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 EARNTCLLFSPKDSSLSSGALANILAIFKKHDINLVHIESRSSLRVPG-YEFFVEADGKSGALGK 91
            |:..|.::||.|:   ..|.|...|.:|::..:|:||||||.|.|... .|.||:.:.......:
Human    60 ESGKTAVVFSLKN---EVGGLVKALRLFQEKRVNMVHIESRKSRRRSSEVEIFVDCECGKTEFNE 121

  Fly    92 AIEDVKEQCSYFNIISRDYKDNATA-------VPWFPRRIRDLDRFANQILSYGSELDADHPGFT 149
            .|:.:|.|.:   |::.:..:|...       ||||||:|.:||:.::::|.||||||||||||.
Human   122 LIQLLKFQTT---IVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFK 183

  Fly   150 DPEYRKRRKYFADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYNHVFPLLVD 214
            |..||:|||||.|:|..||:|:|:|.|:||:||.:|||::||.|:|||.|||||||...||||..
Human   184 DNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTK 248

  Fly   215 NCGFREDNIPQLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPMYTPE 279
            .||:||||:|||||||.||::.:|||:|||||.||.||||||||:||||.||||||.|.|:||||
Human   249 YCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYIRHGSDPLYTPE 313

  Fly   280 PDVCHELMGHVPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQEGELKAYGA 344
            ||.||||:|||||.|||.|||||||||||||||.|:.::||:|.::||:|:|:|:|||:|:||||
Human   314 PDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGA 378

  Fly   345 GLLSSYGELEYCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKFANSIPRPF 409
            |||||.|||::.|:||..:|.|:|:.|.:.:..||.||..|:|::|||.||||...||.||.|||
Human   379 GLLSSIGELKHALSDKACVKAFDPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPF 443

  Fly   410 GVRYNAYTQSVEVLDSKPQISNLMDNINSEFQILQNAVAKL 450
            .|.:|.||||:|:|.....|.|::.::.|:...:.:|:.|:
Human   444 SVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKM 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hn	NP_001261542.1	Phe4hydrox_tetr	15..451	CDD:130335	231/431 (54%)
		ACT_AAAH	32..107	CDD:153176	24/75 (32%)
		Biopterin_H	118..447	CDD:278766	202/328 (62%)
TPH2	NP_775489.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..58
		Trp_5_monoox	52..485	CDD:130337	231/431 (54%)
		ACT	64..137	CDD:298841	24/78 (31%)
		Biopterin_H	152..482	CDD:278766	203/329 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3186
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54212
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100921
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720