DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hn and th

DIOPT Version :9

Sequence 1:	NP_001261542.1	Gene:	Hn / 38871	FlyBaseID:	FBgn0001208	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_031756384.1	Gene:	th / 100488900	XenbaseID:	XB-GENE-992305	Length:	491	Species:	Xenopus tropicalis

Alignment Length:	421	Identity:	214/421 - (50%)
Similarity:	289/421 - (68%)	Gaps:	12/421 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LLFSPKDSSLSSGALANILAIFKKHDINLVHIESRSSLRVPG----YEFFVEADGKSGALGKAIE 94
            ||||.|.|..||  |:..|.:|:..:..:.|:|:|...|..|    .|:||..:.....|...:.
Frog    78 LLFSLKGSKPSS--LSRTLKVFETFEAKIQHLETRPGRRSVGTAGELEYFVRCEVHHSDLSTLMS 140

  Fly    95 DVKEQCSYFNIISRDYKDNATAVPWFPRRIRDLDRFANQILSYGSELDADHPGFTDPEYRKRRKY 159
            .|:..|........|      .|.|||.:|.|||:..:.:..:..:||.:||||:|.|||||||.
Frog   141 SVRRVCEDVRSTRED------KVHWFPTKIADLDKCHHLVTKFDPDLDLEHPGFSDQEYRKRRKM 199

  Fly   160 FADIAYNYKHGEPLPHVDYTKEEIETWGIIFRNLTKLYKTHACREYNHVFPLLVDNCGFREDNIP 224
            .||||:||:||:|:|.|:|..|||.||..::..|..||.||||:|:...|.||..:||:.|||||
Frog   200 IADIAFNYRHGDPIPRVEYLPEEIATWKEVYSTLRSLYPTHACKEHLEAFQLLEAHCGYSEDNIP 264

  Fly   225 QLEDVSNFLRDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPMYTPEPDVCHELMGH 289
            ||:|||:||::.:||||||||||||:|||||.||||||..||||||.|.||::||||.||||:||
Frog   265 QLQDVSSFLKEKSGFTLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGH 329

  Fly   290 VPLFADPAFAQFSQEIGLASLGAPDDYIEKLSTIFWFTVEYGVCRQEGELKAYGAGLLSSYGELE 354
            ||:.||..||||||:||||||||.|:.||||:|::|||||:|:|:||||:||||||||||:|||.
Frog   330 VPILADRTFAQFSQDIGLASLGATDEEIEKLATLYWFTVEFGLCKQEGEIKAYGAGLLSSFGELL 394

  Fly   355 YCLTDKPQLKDFEPEVTGVTKYPITQFQPLYYVADSFETAKEKTIKFANSIPRPFGVRYNAYTQS 419
            :.|:|:|:::.|.|:...|..|....:|.:|::::||..||||...:|:.|.|||.||::.||.|
Frog   395 HALSDEPEVRPFNPDDAAVQPYQDQNYQSVYFISESFPDAKEKLRVYASHIKRPFAVRFDPYTDS 459

  Fly   420 VEVLDSKPQISNLMDNINSEFQILQNAVAKL 450
            :|||:|..:|.:.:|.:..|.|.|.||::.|
Frog   460 IEVLNSAGRIQSSLDGLRDELQTLSNALSTL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hn	NP_001261542.1	Phe4hydrox_tetr	15..451	CDD:130335	214/421 (51%)
		ACT_AAAH	32..107	CDD:153176	22/76 (29%)
		Biopterin_H	118..447	CDD:278766	188/328 (57%)
th	XP_031756384.1	TOH_N	2..26	CDD:403668
		ACT_TH	38..153	CDD:153202	22/76 (29%)
		Biopterin_H	158..488	CDD:395280	189/329 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000587
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000