DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7409 and CRYAA

DIOPT Version :9

Sequence 1:	NP_648155.1	Gene:	CG7409 / 38870	FlyBaseID:	FBgn0035817	Length:	154	Species:	Drosophila melanogaster
Sequence 2:	NP_000385.1	Gene:	CRYAA / 1409	HGNCID:	2388	Length:	173	Species:	Homo sapiens

Alignment Length:	152	Identity:	44/152 - (28%)
Similarity:	73/152 - (48%)	Gaps:	21/152 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YRRRLWRDW---DLNDWDL---------PYWKRSLSRVGSAPDLSRVIVGKDGFEANVDVHLFKP 69
            |..||:..:   .|.::||         ||:::||.|......:|.|...:|.|...:||..|.|
Human    18 YPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISEVRSDRDKFVIFLDVKHFSP 82

  Fly    70 YEISVKTSGDTVVVEAKHEKRRDGDTFVGRHIVKRFVLPRGYYPNDVRSELSSDGILTVKCPPYL 134
            .:::||...|.|.:..||.:|:|...::.|...:|:.||.....:.:...||:||:||. |.|.:
Human    83 EDLTVKVQDDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTF-CGPKI 146

  Fly   135 TN-------ERSVYV-RQVGPS 148
            ..       ||::.| |:..|:
Human   147 QTGLDATHAERAIPVSREEKPT 168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7409	NP_648155.1	metazoan_ACD	54..131	CDD:107247	24/76 (32%)
CRYAA	NP_000385.1	Crystallin	1..51	CDD:395419	8/32 (25%)
CRYAA	NP_000385.1	ACD_alphaA-crystallin_HspB4	60..145	CDD:107245	27/85 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920