Protein Alignment Snmp2 and Scarb2

DIOPT Version :10

• Sequence 1: NP_001163372.1
• Gene: Snmp2 / 38868
• FlyBaseID: FBgn0035815
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_031670.1
• Gene: Scarb2 / 12492
• MGIID: 1196458
• Length: 478
• Species: Mus musculus
• Alignment Length: 545
• Identity: 135/545 - (24%)
• Similarity: 250/545 - (45%)
• Gaps: 100/545 - (18%)

  Fly     6 LIVSALGVCVAVLGGYCGWILFPNMVHKKVEQSVVIQDGSEQFKRFVNLPQPLNFKVYIFNVTNS 70
            |:|:::.:.||        .:|...|.:.:|:::|:|:|::.|..:...|.|:..:.|.|||||.
Mouse    16 LLVTSVTLLVA--------RVFQKAVDQTIEKNMVLQNGTKVFNSWEKPPLPVYIQFYFFNVTNP 72

  Fly    71 DRIQQGAIPIVEEIGPYVYKQFRQKKVKHFSRDGSKISYVQNVHFDFDAVASAPYTQDDRIVALN 135
            :.|.||.||::||:|||.|::.|.|....|..:|:.||.|.|..:.|:...|......|.|..:|
Mouse    73 EEILQGEIPLLEEVGPYTYRELRNKANIQFGENGTTISAVTNKAYVFERNQSVGDPNVDLIRTIN 137

  Fly   136 MHMNAFLQVFEREITDIFQGFANRLNSRLNQTPGVRVLKRLMERIRGKRKSVLQISENDPGLALL 200
            :.:        ..:.|:.|               :.:|:.|:|
Mouse   138 IPL--------LTVVDLAQ---------------LTLLRELIE---------------------- 157

  Fly   201 LVHLNANLKAVFNDPRSMFVSTSVREYLFDGVRFCINPQGIAKAICNQIKESGSKTIREKSDGSL 265
                 |.|||.   .:.:||..:|.|.|:          |....|.:.:...       |.|.|.
Mouse   158 -----AMLKAY---QQKLFVIHTVHELLW----------GYKDEILSLVHIF-------KPDVSP 197

  Fly   266 AFSFFGHKNGSGHEVYEVHTGKGDPMRVLEIQKLDDSHNLQVWLNASSEGETSVCNQINGTDASA 330
            .|..|..:||:....|...||:.:.:...:|.:.:...:|..|       .|..||.|||||..:
Mouse   198 NFGLFYERNGTNDGEYVFLTGEDNYLNFSKIVEWNGKTSLDWW-------TTDTCNMINGTDGDS 255

  Fly   331 YPPFRQRGDSMYIFSADICRSVQLFYQTDIQYQGIPGYRYSIGENFINDIGPEHDNECFCVDKLA 395
            :.|...:.:.:|:|.:|:||||.:.:.:....:|:|.:||.:....:.:..   :|..||:.
Mouse   256 FHPLISKDEVLYLFPSDLCRSVHITFSSFENVEGLPAFRYKVPAEILANTS---ENAGFCIP--- 314

  Fly   396 NVIKRKNGCLYAGALDLTTCLD-APVILTLPHMLGASNEYRKMIRGLKPDAKKHQTFVDVQSLTG 459
                 :..|:.:|.|:::.|.: ||:|::.||...|..::...|:|:.|:.::|::|||:..|||
Mouse   315 -----EGNCMDSGVLNISICKNGAPIIMSFPHFYQADEKFVSAIKGMHPNKEEHESFVDINPLTG 374

  Fly   460 TPLQGGKRVQFNMFLKSINRIGITENLPTVLMPAIWVEEGIQLNGEMVAFFKKKLINTLKTLNIV 524
            ..|:|.||.|.|.:::.::....|.::.|::.|.:::.|.:.::.|.....|..:..||...||.
Mouse   375 IILRGAKRFQINTYVRKLDDFVETGDIRTMVFPVMYLNESVLIDKETANQLKSVINTTLVVTNIP 439

  Fly   525 HWATLCGGIGVAVACLIYYIYQRGR 549
            :   :...:||....:..::..||:
Mouse   440 Y---IIMALGVFFGLVFTWLACRGQ 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snmp2	NP_001163372.1	CD36	10..543	CDD:460076	131/533 (25%)
Scarb2	NP_031670.1	CD36	28..457	CDD:460076	129/519 (25%)
		Important for interaction with GBA1	155..191		13/75 (17%)