DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7457 and Bard1

DIOPT Version :9

Sequence 1:	NP_001303376.1	Gene:	CG7457 / 38865	FlyBaseID:	FBgn0035812	Length:	1405	Species:	Drosophila melanogaster
Sequence 2:	NP_072144.2	Gene:	Bard1 / 64557	RGDID:	621072	Length:	768	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	108/460 - (23%)
Similarity:	167/460 - (36%)	Gaps:	138/460 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 VKVCQTLDELVLTSSVDYAKLKG-LYEKLGDGCCHLMNYEKALTYYQKMLENAELNQESGK---- 352
            :|:.:.||.::..    |:||:. |::..|..       .|..|....:|.:||..:.|.|
  Rat    89 LKINRQLDSMIQL----YSKLQNLLHDNKGSD-------SKDDTSRASLLGDAERKKNSVKMWFS 142

  Fly   353 ------SLVPIYVSLYQTYRDNGQFDKALEYLWKEFELNQDAPSEAFTTLCTIAEICEQQSHPFW 411
                  ..|...||: ||.....:.|||.|.  ..||.....|....:|....|.....:.||
  Rat   143 PRSKKIRCVVNKVSV-QTQPQKAKDDKAQEA--SVFEFVSATPPVVVSTRAKTASRTSAKKHP-- 202

  Fly   412 TVHDVYQKALRQADKAGS-----------CSDKLVKIAMVRLRRLMLKHNMQVLVENLEADATAK 465
                  :|::.:.::.|:           ..:||.:..:|...:.::..|.:|   |.|.|..|.
  Rat   203 ------KKSVAKINREGNFRPETRDSRFDSKEKLKEEKVVSFSQTLVMENSRV---NGEIDLLAS 258

  Fly   466 GIDLDQE-------------------ESVGDDEEE--------------SDGGGTAVQQ------ 491
            |..::.|                   ::|...||.              |||......:
  Rat   259 GSVVESECSGSFAEVSLPLAEHIVSPDTVSKSEEAPEKKVCVEDRCPVGSDGNPKGCHRPPTSTS 323

  Fly   492 -----NTPDWDDDF-------------------------DLATLTDSDASDLDETEKP------- 519
                 |.|....:.                         |:.....|:|||...:..|
  Rat   324 KKCGSNVPSTSGEIREPTLLAENVVLVDCSSLPSGRLQVDVTLRRQSNASDDSLSLSPGTPPSLL 388

  Fly   520 ----------RPQRTTRGNRTLVIKKNNKGETQLHQACISGNLELVRRLIDQGHTVNVRDHAGWL 574
                      :|......:.....|:|::|||.||.|.|.|::..|..|:..|:..||:|||||.
  Rat   389 NNSTHRQMMSKPSTVKLSSGIPARKRNHRGETLLHIASIKGDISSVEYLLQNGNDPNVKDHAGWT 453

  Fly   575 PLHEACNHGYREIVELLLDKGAASAINDKGGTSCDGITPLFDACSNGFLDVAELLLDRGADATVR 639
            ||||||:||:.:||||||...|  .:|.   |.....:||.||..||.:|:.::||..||.....
  Rat   454 PLHEACSHGHLKIVELLLQHNA--LVNT---TGYHNDSPLHDAAKNGHIDIVKVLLSHGASRNAV 513

  Fly   640 TDYNE 644
            ..:.|
  Rat   514 NIFGE 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7457	NP_001303376.1	TPR_12	21..95	CDD:290160
		TPR	68..387	CDD:223533	26/104 (25%)
		TPR repeat	163..191	CDD:276809
		TPR repeat	196..233	CDD:276809
		TPR repeat	238..273	CDD:276809
		TPR repeat	316..342	CDD:276809	4/25 (16%)
		TPR repeat	347..384	CDD:276809	12/46 (26%)
		TPR repeat	389..422	CDD:276809	6/32 (19%)
		ANK	535..647	CDD:238125	48/110 (44%)
		ANK repeat	539..569	CDD:293786	13/29 (45%)
		Ank_2	543..639	CDD:289560	43/95 (45%)
		ANK repeat	571..604	CDD:293786	19/32 (59%)
		ANK repeat	609..639	CDD:293786	11/29 (38%)
		LRR_RI	1063..1360	CDD:238064
		leucine-rich repeat	1088..1115	CDD:275381
		leucine-rich repeat	1116..1170	CDD:275381
		leucine-rich repeat	1199..1225	CDD:275381
		leucine-rich repeat	1226..1261	CDD:275381
		leucine-rich repeat	1262..1289	CDD:275381
		leucine-rich repeat	1290..1315	CDD:275381
Bard1	NP_072144.2	Required for BRCA1 binding. /evidence=ECO:0000250	20..113		7/27 (26%)
		zf-RING_6	35..99	CDD:405517	3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..226		6/45 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..334		5/26 (19%)
		ANKYR	366..558	CDD:223738	55/158 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..414		6/43 (14%)
		ANK 1	417..449		13/31 (42%)
		ANK repeat	417..448	CDD:293786	13/30 (43%)
		Ank_2	422..514	CDD:403870	43/96 (45%)
		ANK 2	450..482		20/36 (56%)
		ANK repeat	450..481	CDD:293786	19/35 (54%)
		ANK 3	483..515		11/31 (35%)
		ANK repeat	483..514	CDD:293786	11/30 (37%)
		ANK 4, degenerate	516..536		1/3 (33%)
		Flexible linker. /evidence=ECO:0000250	544..548
		BRCT_Bard1_rpt1	561..637	CDD:349366
		BRCT_Bard1_rpt2	662..762	CDD:349352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930