DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7457 and tonsl

DIOPT Version :10

Sequence 1:NP_648150.1 Gene:CG7457 / 38865 FlyBaseID:FBgn0035812 Length:1405 Species:Drosophila melanogaster
Sequence 2:NP_001104618.1 Gene:tonsl / 492655 ZFINID:ZDB-GENE-041111-230 Length:1427 Species:Danio rerio


Alignment Length:1540 Identity:433/1540 - (28%)
Similarity:676/1540 - (43%) Gaps:284/1540 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EEKRYLKRKEKARSDGNRDQVAVSCNQLGDFYNQQGKYTDAVREYVQEAQIYASMGKELETAKAK 66
            |.|:..|.|.||:|..|..:.|..|||||:.|.:.|.|..|:.|:.||..:...:...:.:|.|.
Zfish     6 EIKQLQKAKSKAQSSNNLKEEASLCNQLGEVYAKTGDYQAAIEEHRQELALSEILHDVIGSAVAN 70

  Fly    67 RMVGEMYTLLCDYDAAKDHINDYLKIAKRLKNQVEEQRAYATLGRVHLLHGQSLADSSASGSMEQ 131
            |.:||.|..|.:.:||..|...:|.:|:.:.:..|||||.||:||.:|.    |.||..|.:  .
Zfish    71 RKIGECYAELGNIEAALKHQRLHLNLARSVHDAAEEQRALATIGRTYLF----LFDSDQSAN--S 129

  Fly   132 LKLAEKNFLRSLLLIKD-LSGQISKLEQLDMQARCYLNIGVVKEHMEAFQESIEYIDKAIKISKT 195
            ||.||..|.|||.::.: |.|.:|..|..:|:||..||:|.|.:.|:..|...:.|.::|.|::.
Zfish   130 LKHAEDAFKRSLAIVDERLEGTVSPREISEMKARLLLNLGCVYDGMKEPQRCSDLIRQSIYIAEK 194

  Fly   196 HELWDLTHLCYISMSLLYICKKNDATAALRFCNMALEVAKRFPNKVKKICETLITKAEILIKAGD 260
            :.|.:..:....::..::. :....:.|:|....:.|.|::..:|..: .|...:..:||:..||
Zfish   195 NNLLEDLYRANFNLGSIHF-RNGQHSRAMRCFEQSKECARKMKDKFSE-SECFHSIGKILLHLGD 257

  Fly   261 FASAKQILTKAYKKNTPDENDRVNIEKQLRIVVKVCQTLDELV--LTSSVDYAKLKGLYEKLGDG 323
            |::|::.|.||:...:...:||..::|..|..::.|| |::..  :|....:..| .|.|:|||.
Zfish   258 FSAARRSLKKAFCLGSQQPSDREAVKKDFRHAIRGCQ-LEQTAAEVTQKFSHEAL-DLSEQLGDL 320

  Fly   324 CCHLMNYEKALTYYQKMLENAELNQESGKSLVPIYVSLYQTYRDNGQFDKALEYLWKEFELNQDA 388
            .|.:..|.|||..||..|..||...:..:.|..|:|||..||.|..|..:|:|:..:|.:|.:..
Zfish   321 YCKVGCYSKALEAYQTQLACAEALAKPARELAVIHVSLAATYTDLRQHHRAVEHYRQELQLRKGN 385

  Fly   389 PSEAFTTLCTIAEICEQQSHPFWTVHDVYQKALRQADKAGSCSDKLVKIAMVRLRRLMLKHNMQV 453
            |.|...|...:|...|:......|:...:..||..|:|:|          :.:|:|.:|:..:|.
Zfish   386 PKEECETWLNMAVCQEEMCQSMETLDHCFTSALNCAEKSG----------LNKLQRRVLRVWLQA 440

  Fly   454 ---------------LVENLEADATAKGIDLDQEESVGDDEEESDGGGTAVQQNTPDWDDDFDLA 503
                           |:|..|.|    |:.|||.|    ||:|.|    .|..:.|..|.|...:
Zfish   441 QRRCGSSQCDDTEARLMELCERD----GLSLDQSE----DEDEED----EVDNSEPLEDSDIQYS 493

  Fly   504 TLTDSDASDLDETEKPRPQRTTRGNRTLVIKKNNKGETQLHQACISGNLELVRRLIDQGHTVNVR 568
            ...|.|....|:....| ::|.|.||     :|.||||.||:|||.|||:.|:.||:|||.||||
Zfish   494 ESDDEDLEGYDKMVTGR-RKTQRWNR-----RNEKGETVLHRACIEGNLKQVQYLIEQGHPVNVR 552

  Fly   569 DHAGWLPLHEACNHGYREIVELLLDKGAASAINDKGGTSCDGITPLFDACSNGFLDVAELLLDRG 633
            |:.||.||||:||:|::|||..|||:||  .:||.||..|.|||||.|..|.|...||.||:.||
Zfish   553 DYCGWTPLHESCNYGHQEIVAFLLDRGA--NVNDPGGRECGGITPLHDTLSCGHFSVARLLVLRG 615

  Fly   634 ADATVRTDYNETCIAGLDKW--------------------------------------RQGAQLV 660
            |..|||.....|.:..|.:|                                      ||..:|.
Zfish   616 ASVTVRNSKGHTPLDTLRQWFKTYSGQLDPETKQECLETEKLIKRALSGDVSVVCAAPRQQKELQ 680

  Fly   661 DGE--QAQYAQLRERLLR---------TLSKVGICSDKNARPLTNFNAKRISREERG-------- 706
            |.:  .|:|:   |.|||         |.....:.:.|::.| .:.:....:|..||        
Zfish   681 DSQLFDAEYS---EPLLRESPPSPPPITRPAATVPTSKDSAP-KHRSTSASTRRPRGMEVDVLYG 741

  Fly   707 ---SMSEEEDEEEALH--------------ESNRRSLSHNRSGSEYGAKKSKSSTQPSASK-EYR 753
               |.|:..|.:.:|.              :|.:...|.....|.||.|::....|..:.: ||:
Zfish   742 DDSSSSDNPDSDCSLSPLRPVRSRPRSPPAQSPQEVPSSQELPSVYGIKETTVPPQSESGRLEYQ 806

  Fly   754 SVMAHL-KRPNRL----NDDPPSTST--LNKHKRNAFLSEDEVDADNWLID---DVGPERKRKRI 808
            ..|.:| ...:||    ..||..|||  ::.:.|.|.:.||:..||:||.|   |:.|::|| |:
Zfish   807 KAMQNLGSAKSRLFSQSLSDPAFTSTPAVSANSRAALVPEDQYLADDWLEDDLIDMQPKKKR-RV 870

  Fly   809 NSGDLSRRTS--KENFQDTALSLPANWEDDLLQATPENEYSQRQKQMRKLTLSRSSSMSSNHSSS 871
            :..:.:|.|:  .:|...|...:|.                      |..:.|...|:|....|:
Zfish   871 SEHNATRETTSRSQNNSSTIAEVPP----------------------RVQSCSSRGSLSLKKGSN 913

  Fly   872 ATSSRKKHQ--ATLLDSGFSRFRSESPLGSESSQDGTTSLISVRTIEPDSTTSTIQVLISPAKSS 934
            .....|.:|  ..::.......||:||:.::.|..                   ||   .||   
Zfish   914 KPRQVKMNQLPGMVMLGRREVSRSQSPIMTQESDH-------------------IQ---EPA--- 953

  Fly   935 PIKVQATPV---------LATTVSFKVKIQDELLLVPIERKKLQDINIRWLAEEAGRRYNKLTGL 990
            |...||.|.         :...:..:||:||.:.|:|:...:.....:.||.::|.:||.::.||
Zfish   954 PPSHQAMPPASFQNRAAHVPAPIRMRVKVQDNVFLIPVPHSEADSCTVAWLCDQAAQRYYQMCGL 1018

  Fly   991 TPLLRLKTADGFAYEETDPVSVALEQN-MLMASILDWKISPLSQRYEEMCLQMQKTVDNKVKLLL 1054
            .|.|.|: .:|.....|||:...|..| .::|.:..|.:.||.:||.:.|..:....:.:|..:.
Zfish  1019 LPRLSLQ-KEGALLLPTDPLLAVLHTNEEVLAEVCSWDLPPLPERYRKACESLGVEENRRVSRVC 1082

  Fly  1055 ERSQNNNMLELSGLWMRAEKTEPIFKALLHQARLTVLDLSCNFIGNEGCQQLAKSLPTLLQLKAL 1119
            |...:::.:.:.||.:......|:.:||..||.||.|.:|.|.:.:|...::..:..|:.:|:.|
Zfish  1083 EVQDSSSCVSVCGLSLSPASLNPLLRALKLQASLTELRISANRLNDELLPEMMAAAATMPRLRVL 1147

  Fly  1120 RLQCNAIGSHGLEALLCGQGMDKLE--------LLEELNLNQNPLGNASVRILSKYCAS-PAGQA 1175
            .:..|.|...||.     :..|..|        .||||||:.||||:...:.|:...:| |   .
Zfish  1148 DISANQITGEGLR-----KASDAFETRSQAAFPCLEELNLSMNPLGDGWTQALASLLSSCP---L 1204

  Fly  1176 LTCLQLAQCELTE--LQDFDL-------GFNKLTRFDISFNQLTQQSVRRLTDQLNSCRLEQLNL 1231
            |:.|.|..|.|:.  ||...|       ....:....:|.|.|.......:...|....|..|.|
Zfish  1205 LSSLSLQACGLSARFLQQHRLLLANAMASTGNMRSVCLSHNALGSTGFELVLKTLPMHCLTHLEL 1269

  Fly  1232 SYV-RWPLDDASGFALSERLVTLFEGGTCERFVGVQLAGCGLNDAHMYNISQHLAKAKQLQMLDI 1295
            |.| |.|.|..|    .|.|..|...|.|. ...:.|:|.||.|..:..:::.|.....|..||:
Zfish  1270 SAVCRGPSDQPS----MEILTKLLAQGDCP-LTHLNLSGNGLTDHSVLLLARCLPVCPSLVSLDL 1329

  Fly  1296 SDNSNLSGTTLGYILDELPQLR--------------DLLAVNCTNLLD----DIRL--QKLEQLK 1340
            |.|..::.|.|..:|:.|.:.|              ..||.:|.:.|.    |:||  |.|.:|.
Zfish  1330 SANPLVTSTGLHSLLNGLVEARRPLGHLNLQGCQVSGPLAEDCLDSLSDHIRDLRLCSQSLNKLD 1394

  Fly  1341 QLPRRLELTVDEQVFSMPGALETLQSIWQLQFGDKAKMLTTSNSR 1385
            |                    :.||..|:.:  .:|..:.:.||:
Zfish  1395 Q--------------------DALQQSWKRR--TEAVHIFSRNSK 1417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7457NP_648150.1 LapB 28..385 CDD:442196 112/359 (31%)
TPR repeat 163..191 CDD:276809 9/27 (33%)
TPR repeat 196..233 CDD:276809 3/36 (8%)
TPR repeat 238..273 CDD:276809 11/34 (32%)
TPR repeat 316..342 CDD:276809 12/25 (48%)
TPR repeat 347..384 CDD:276809 12/36 (33%)
TPR repeat 389..422 CDD:276809 7/32 (22%)
ANKYR <532..>645 CDD:440430 64/112 (57%)
ANK repeat 539..569 CDD:293786 20/29 (69%)
ANK repeat 571..604 CDD:293786 19/32 (59%)
ANK repeat 609..639 CDD:293786 16/29 (55%)
RNA1 <1038..1233 CDD:444072 53/212 (25%)
leucine-rich repeat 1088..1115 CDD:275381 7/26 (27%)
leucine-rich repeat 1116..1170 CDD:275381 19/61 (31%)
leucine-rich repeat 1199..1225 CDD:275381 4/25 (16%)
leucine-rich repeat 1226..1261 CDD:275381 14/35 (40%)
leucine-rich repeat 1262..1289 CDD:275381 6/26 (23%)
leucine-rich repeat 1290..1315 CDD:275381 9/24 (38%)
tonslNP_001104618.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 7/14 (50%)
TPR 25..>233 CDD:440225 67/214 (31%)
TPR 1 27..60 13/32 (41%)
TPR repeat 27..55 CDD:276809 13/27 (48%)
TPR repeat 66..96 CDD:276809 11/29 (38%)
TPR 2 67..100 12/32 (38%)
TPR repeat 101..142 CDD:276809 21/46 (46%)
TPR 3 107..147 20/45 (44%)
TPR 162..>397 CDD:440225 67/238 (28%)
TPR 4 162..195 11/32 (34%)
TPR repeat 162..190 CDD:276809 9/27 (33%)
TPR repeat 195..231 CDD:276809 3/36 (8%)
TPR 5 202..235 4/33 (12%)
TPR 6 242..275 10/32 (31%)
TPR repeat 242..268 CDD:276809 8/25 (32%)
TPR 7 311..344 16/33 (48%)
TPR repeat 316..345 CDD:276809 13/28 (46%)
TPR repeat 351..381 CDD:276809 12/29 (41%)
TPR 8 352..385 12/32 (38%)
TPR repeat 386..418 CDD:276809 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 465..502 14/44 (32%)
ANKYR <517..>630 CDD:440430 67/119 (56%)
ANK 1 522..551 19/28 (68%)
ANK repeat 523..553 CDD:293786 20/29 (69%)
ANK repeat 555..586 CDD:293786 19/32 (59%)
ANK 2 555..584 17/30 (57%)
ANK repeat 591..622 CDD:293786 17/30 (57%)
ANK 3 591..620 15/28 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 692..801 20/109 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 865..922 14/79 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 941..961 8/44 (18%)
RNA1 <1106..1404 CDD:444072 88/330 (27%)
LRR 1 1113..1137 8/23 (35%)
leucine-rich repeat 1116..1143 CDD:275380 7/26 (27%)
LRR 2 1141..1168 7/31 (23%)
leucine-rich repeat 1144..1171 CDD:275380 8/31 (26%)
LRR 3 1174..1197 11/22 (50%)
leucine-rich repeat 1177..1228 CDD:275380 21/53 (40%)
LRR 4 1234..1258 3/23 (13%)
leucine-rich repeat 1237..1263 CDD:275381 4/25 (16%)
leucine-rich repeat 1264..1295 CDD:275381 13/34 (38%)
LRR 5 1293..1316 6/23 (26%)
leucine-rich repeat 1296..1323 CDD:275381 6/26 (23%)
LRR 6 1321..1346 8/24 (33%)
leucine-rich repeat 1324..1349 CDD:275381 9/24 (38%)
LRR 7 1377..1400 8/42 (19%)

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