DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7457 and TONSL

DIOPT Version :9

Sequence 1:	NP_001303376.1	Gene:	CG7457 / 38865	FlyBaseID:	FBgn0035812	Length:	1405	Species:	Drosophila melanogaster
Sequence 2:	NP_038460.4	Gene:	TONSL / 4796	HGNCID:	7801	Length:	1378	Species:	Homo sapiens

Alignment Length:	1472	Identity:	414/1472 - (28%)
Similarity:	644/1472 - (43%)	Gaps:	260/1472 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EEKRYLKRKEKARSDGNRDQVAVSCNQLGDFYNQQGKYTDAVREYVQEAQIYASMGKELETAKAK 66
            |.::..|.|.||:..|.|.:.|..|:|||:.....|:|.:|:.::.||.|:.......|..|.|.
Human     6 ELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAH 70

  Fly    67 RMVGEMYTLLCDYDAAKDHINDYLKIAKRLKNQVEEQRAYATLGRVHLLHGQSLADSSASGSMEQ 131
            |.:||....:.||.||..|.:.||::|..|:|..|.|||:||:||.||    .:.|...  |.:.
Human    71 RKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHL----DIYDHCQ--SRDA 129

  Fly   132 LKLAEKNFLRSLLLI-KDLSGQISKLEQLDMQARCYLNIGVVKEHMEAFQESIEYIDKAIKISKT 195
            |..|:..|.:||.:: ::|.|.:::.|..:|:.|.|||:|:..|.::......:|..|:|.:::.
Human   130 LLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIFLAEQ 194

  Fly   196 HELWDLTHLCYISMSLLYICKKNDATAALRFCNMALEVA----KRFPNKVKKICETLITKAEILI 256
            :.|::.......::..:: .:....:.|:|....|.|.|    |||...     |..:..|::|.
Human   195 NHLYEDLFRARYNLGTIH-WRAGQHSQAMRCLEGARECAHTMRKRFMES-----ECCVVIAQVLQ 253

  Fly   257 KAGDFASAKQILTKAYKKNTPDENDRVNIEKQLRIVVKVCQTLDELVLTSSVDYAKLKGLYEKLG 321
            ..|||.:||:.|.|||:..:.....|..|.:.|:.|:.|.:...:|......|......:.|:||
Human   254 DLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLEEAEGRDPQGAMVICEQLG 318

  Fly   322 DGCCHLMNYEKALTYYQKMLENAELNQESGKSLVPIYVSLYQTYRDNGQFDKALEYLWKEFELNQ 386
            |......::.:|...|||.|..|||....|.....|:|||..|..|......|:.:..:|..|..
Human   319 DLFSKAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDMKDHHGAVRHYEEELRLRS 383

  Fly   387 DAPSEAFTTLCTIAEICEQQSHPFWTVHDVYQKALRQADKAGSCSDKLVKIAMVRLRRLMLK--H 449
            ....|...|...||...|:....:..:...:||||       ||:.:..:   .:|:|.:|:  |
Human   384 GNVLEEAKTWLNIALSREEAGDAYELLAPCFQKAL-------SCAQQAQR---PQLQRQVLQHLH 438

  Fly   450 NMQVLVENLEADATAKGIDLDQEESVGDDEEE----SDGGGTAVQQ-------NTPDWDDDFDLA 503
            .:|:.::..||..|...:   :|.||.:||:|    .:...||..:       ...:.:||
Human   439 TVQLRLQPQEAPETETRL---RELSVAEDEDEEEEAEEAAATAESEALEAGEVELSEGEDD---- 496

  Fly   504 TLTDSDASDLDETEKPR----PQRTTRGNRTLVIKKNNKGETQLHQACISGNLELVRRLIDQGHT 564
              ||.....|:|.|:.:    .::.::.||     :|:.|||.||:|||.|.|..|:.|:.|||.
Human   497 --TDGLTPQLEEDEELQGHLGRRKGSKWNR-----RNDMGETLLHRACIEGQLRRVQDLVRQGHP 554

  Fly   565 VNVRDHAGWLPLHEACNHGYREIVELLLDKGAASAINDKGGTSCDGITPLFDACSNGFLDVAELL 629
            :|.||:.||.|||||||:|:.|||..|||.||  |::|.||..|:|||||.||.:.|..:|||||
Human   555 LNPRDYCGWTPLHEACNYGHLEIVRFLLDHGA--AVDDPGGQGCEGITPLHDALNCGHFEVAELL 617

  Fly   630 LDRGADATVRTDYNETCIAGLDKW-RQGAQLVDGEQAQYAQLRERLLR----------------- 676
            |:|||..|:||....:.:..|.:| :...:.:|.|..|.|:..|.||:
Human   618 LERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAASGQDPHSSQAFHTP 682

  Fly   677 --------TLSKVGIC-------------SDKNARPLTNFNAKRISREER--------GSMSEEE 712
                    |...:..|             |..:.|......|..::|..|        .|.||.|
Human   683 SSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHVRVSPGQAAPAMARPRRSRHGPASSSSSSEGE 747

  Fly   713 DEEEALHESNRR---SLSHNR--SGSEYGAKKSKSSTQPSASKEYRSVMAHL-KRPNRLNDDPPS 771
            |.......|.:|   |.:..|  :.:...|...:::|..::...|::.:..: ...:||...||.
Human   748 DSAGPARPSQKRPRCSATAQRVAAWTPGPASNREAATASTSRAAYQAAIRGVGSAQSRLGPGPPR 812

  Fly   772 TSTLNKHKRNAFLSEDEVDADNWLIDDVGPERKR--KRINSGDLSRRTSKENFQDTALSLPANWE 834
            ..:.....:.|.:.|:|..|.:||..|:...|.|  :...:|| :||.|..:..|:..|.|
Human   813 GHSKALAPQAALIPEEECLAGDWLELDMPLTRSRRPRPRGTGD-NRRPSSTSGSDSEESRP---- 872

  Fly   835 DDLLQATPENEYSQRQKQMRKLTLSRSSSMSSNHSSSATSSRKKHQATLLDSGFSRFRSESPLGS 899
                        ..|.||:| ||..:|.|...|                  :|.|...||.| ||
Human   873 ------------RARAKQVR-LTCMQSCSAPVN------------------AGPSSLASEPP-GS 905

  Fly   900 ESSQDGTTSLISVRTIEPDSTTSTIQVLISPAKSSPIKVQATPVLATTVSFKVKIQDELLLVPIE 964
            .|:.         |..||...:|.....:.||...||:|            :|::||.|.|:|:.
Human   906 PSTP---------RVSEPSGDSSAAGQPLGPAPPPPIRV------------RVQVQDHLFLIPVP 949

  Fly   965 RKKLQDINIRWLAEEAGRRYNKLTGLTPLLRLKTADGFAYEETDPVSVALEQN-MLMASILDWKI 1028
            ... ...::.||||:|.:||.:..||.|.|.|: .:|......|.:...|:.| .::|.:..|.:
Human   950 HSS-DTHSVAWLAEQAAQRYYQTCGLLPRLTLR-KEGALLAPQDLIPDVLQSNDEVLAEVTSWDL 1012

  Fly  1029 SPLSQRYEEMCLQMQKTVDNKVKLLLERSQNNNMLELSGLWM----------RAEKTEPIFKAL- 1082
            .||:.||...|..:.:.         |..|....:||.||.:          :|:.| |:.:||
Human  1013 PPLTDRYRRACQSLGQG---------EHQQVLQAVELQGLGLSFSACSLALDQAQLT-PLLRALK 1067

  Fly  1083 LHQARLTVLDLSCNFIGNEGCQQLAKSLPTLLQLKALRLQCNAIGSHGLEALLCG-QGMDKLELL 1146
            ||.| |..|.|:.|.:|::...:|..:|.|:..|..|.|..|.:|..||..|..| .|...|:.|
Human  1068 LHTA-LRELRLAGNRLGDKCVAELVAALGTMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQSL 1131

  Fly  1147 EELNLNQNPLGNASVRILSKYC-ASPAGQALTCLQLAQCEL-------------TELQDFDLGFN 1197
            |||:|:.||||:...:.|:... |.|   .|:.|:|..|..             :..||.:
Human  1132 EELDLSMNPLGDGCGQSLASLLHACP---LLSTLRLQACGFGPSFFLSHQTALGSAFQDAE---- 1189

  Fly  1198 KLTRFDISFNQLTQQSVRRLTDQLNSCRLEQLNLSYVRWPLDDASGFALSERLVTLFEGGTCERF 1262
            .|....:|:|.|...::.|....|.:..|..|.||.|      |:|...|:.:..:|      |:
Human  1190 HLKTLSLSYNALGAPALARTLQSLPAGTLLHLELSSV------AAGKGDSDLMEPVF------RY 1242

  Fly  1263 VGVQLAGCGLNDAHMYNISQHLA-KA-----------KQLQMLDISDNSNLSGTTLGYILDEL-- 1313
            :..:  ||.|  ||:...:.||. ||           ..|..||:|.|..:|..:|..:|..|
Human  1243 LAKE--GCAL--AHLTLSANHLGDKAVRDLCRCLSLCPSLISLDLSANPEISCASLEELLSTLQK 1303

  Fly  1314 -PQLRDLLAVN-CT-------NLLDDIRLQKLEQLKQLPRRL 1346
             ||....|.:: |.       .|.|.|..| |.:|:...|||
Human  1304 RPQGLSFLGLSGCAVQGPLGLGLWDKIAAQ-LRELQLCSRRL 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7457	NP_001303376.1	TPR_12	21..95	CDD:290160	25/73 (34%)
		TPR	68..387	CDD:223533	92/323 (28%)
		TPR repeat	163..191	CDD:276809	8/27 (30%)
		TPR repeat	196..233	CDD:276809	4/36 (11%)
		TPR repeat	238..273	CDD:276809	11/34 (32%)
		TPR repeat	316..342	CDD:276809	8/25 (32%)
		TPR repeat	347..384	CDD:276809	9/36 (25%)
		TPR repeat	389..422	CDD:276809	8/32 (25%)
		ANK	535..647	CDD:238125	62/111 (56%)
		ANK repeat	539..569	CDD:293786	16/29 (55%)
		Ank_2	543..639	CDD:289560	56/95 (59%)
		ANK repeat	571..604	CDD:293786	20/32 (63%)
		ANK repeat	609..639	CDD:293786	18/29 (62%)
		LRR_RI	1063..1360	CDD:238064	96/333 (29%)
		leucine-rich repeat	1088..1115	CDD:275381	8/26 (31%)
		leucine-rich repeat	1116..1170	CDD:275381	21/55 (38%)
		leucine-rich repeat	1199..1225	CDD:275381	6/25 (24%)
		leucine-rich repeat	1226..1261	CDD:275381	9/34 (26%)
		leucine-rich repeat	1262..1289	CDD:275381	9/38 (24%)
		leucine-rich repeat	1290..1315	CDD:275381	9/27 (33%)
TONSL	NP_038460.4	TPR_12	23..99	CDD:290160	26/75 (35%)
		TPR 1	27..60		11/32 (34%)
		TPR repeat	27..55	CDD:276809	10/27 (37%)
		TPR repeat	66..96	CDD:276809	12/29 (41%)
		TPR 2	67..100		13/32 (41%)
		TPR 3	107..147		16/45 (36%)
		TPR repeat	107..131	CDD:276809	11/29 (38%)
		TPR 4	162..195		9/32 (28%)
		TPR repeat	163..190	CDD:276809	8/26 (31%)
		TPR	187..>418	CDD:223533	59/236 (25%)
		TPR repeat	195..231	CDD:276809	4/36 (11%)
		TPR 5	202..235		5/33 (15%)
		TPR 6	242..275		12/37 (32%)
		TPR repeat	242..270	CDD:276809	11/32 (34%)
		TPR repeat	276..300	CDD:276809	5/23 (22%)
		TPR 7	311..344		11/32 (34%)
		TPR repeat	316..339	CDD:276809	7/22 (32%)
		TPR repeat	351..381	CDD:276809	8/29 (28%)
		TPR 8	352..385		9/32 (28%)
		TPR repeat	390..419	CDD:276809	8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..524		9/54 (17%)
		ANK	523..635	CDD:238125	64/118 (54%)
		ANK repeat	528..559	CDD:293786	16/30 (53%)
		ANK 1	528..557		15/28 (54%)
		Ank_2	533..627	CDD:289560	56/95 (59%)
		ANK repeat	561..592	CDD:293786	20/32 (63%)
		ANK 2	561..590		19/30 (63%)
		ANK repeat	594..627	CDD:293786	19/32 (59%)
		ANK 3	597..626		17/28 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..789		18/121 (15%)
		PRR18	707..>919	CDD:292299	58/257 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	842..933		33/136 (24%)
		LRR_RI	1045..1306	CDD:238064	79/285 (28%)
		LRR 1	1069..1093		8/24 (33%)
		LRR_8	1072..1141	CDD:290566	25/68 (37%)
		leucine-rich repeat	1072..1099	CDD:275380	8/26 (31%)
		LRR 2	1097..1122		8/24 (33%)
		leucine-rich repeat	1100..1130	CDD:275380	11/29 (38%)
		LRR 3	1128..1151		11/22 (50%)
		leucine-rich repeat	1131..1158	CDD:275380	12/29 (41%)
		leucine-rich repeat	1159..1190	CDD:275380	6/34 (18%)
		LRR 4	1188..1212		5/27 (19%)
		leucine-rich repeat	1191..1215	CDD:275380	6/23 (26%)
		leucine-rich repeat	1216..1249	CDD:275380	11/46 (24%)
		LRR 5	1247..1270		9/24 (38%)
		leucine-rich repeat	1250..1277	CDD:275380	7/28 (25%)
		LRR 6	1275..1300		8/24 (33%)
		leucine-rich repeat	1278..1300	CDD:275380	8/21 (38%)
		leucine-rich repeat	1308..1333	CDD:275380	5/24 (21%)
		LRR 7	1331..1354		6/15 (40%)
		leucine-rich repeat	1334..1355	CDD:275380	5/11 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8216
eggNOG	1	0.900	-	-		E33208_3BFTE
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22754
Inparanoid	1	1.050	372	1.000	Inparanoid score	I2127
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45608
OrthoDB	1	1.010	-	-		D37202at33208
OrthoFinder	1	1.000	-	-		FOG0007065
OrthoInspector	1	1.000	-	-		oto88308
orthoMCL	1	0.900	-	-		OOG6_108309
Panther	1	1.100	-	-	LDO	PTHR46358
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9641
SonicParanoid	1	1.000	-	-		X5939
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870