DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7457 and Tonsl

DIOPT Version :10

Sequence 1:NP_648150.1 Gene:CG7457 / 38865 FlyBaseID:FBgn0035812 Length:1405 Species:Drosophila melanogaster
Sequence 2:XP_008763809.1 Gene:Tonsl / 366953 RGDID:1307483 Length:1371 Species:Rattus norvegicus


Alignment Length:1438 Identity:403/1438 - (28%)
Similarity:627/1438 - (43%) Gaps:205/1438 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EEKRYL-KRKEKARSDGNRDQVAVSCNQLGDFYNQQGKYTDAVREYVQEAQIYASMGKELETAKA 65
            :|.|.| |.|.:|:.:|...:.||.|:|||:.....|::.:|:.|:.||..:..|:...|..|.|
  Rat     5 QELRQLSKAKARAQRNGQLCEEAVCCHQLGELLASHGRFQEALEEHQQELHLLESVQDTLGCAVA 69

  Fly    66 KRMVGEMYTLLCDYDAAKDHINDYLKIAKRLKNQVEEQRAYATLGRVHL---LHGQSLADSSASG 127
            .|.:||....:.:|.||..|.:.||.:|..|.|..|.|||:||:||.||   .|.|         
  Rat    70 HRKIGERLAEMENYSAALKHQHLYLDLAGSLSNHTELQRAWATIGRTHLDVYDHCQ--------- 125

  Fly   128 SMEQLKLAEKNFLRSLLLIKD-LSGQISKLEQLDMQARCYLNIGVVKEHMEAFQESIEYIDKAIK 191
            |.:.|..|:..|.:||.::.: |.|.:::.|..:|:.|.|||:|:..|.::...:...|..|:|.
  Rat   126 SRDSLLQAQAAFEKSLAIVDEKLEGMLTQRELSEMRTRLYLNLGLTCESLQQTAQCNNYFKKSIF 190

  Fly   192 ISKTHELWDLTHLCYISMSLLYICKKNDATAALRFCNMALEVAK----RFPNKVKKICETLITKA 252
            :::.:.|::.......::..:: .:....:.|:|....|.|.|:    ||   ::..|..|:  :
  Rat   191 LAEQNHLYEDLFRARYNLGAIH-WRGGQHSQAMRCLEGARECARAMKMRF---MESECCMLV--S 249

  Fly   253 EILIKAGDFASAKQILTKAYKKNTPDENDRVNIEKQLRIVVKVCQTLDELVLTSSVDYAKLKGLY 317
            ::|...|||.:||:.|.|||:..:...|.||.|.:.|:.|:.|.:...:|......|......:.
  Rat   250 QVLQDLGDFLAAKRALKKAYRLGSQKPNQRVAICQSLKYVLAVVRLQQQLQEAEGNDLQGAMAIC 314

  Fly   318 EKLGDGCCHLMNYEKALTYYQKMLENAELNQESGKSLVPIYVSLYQTYRDNGQFDKALEYLWKEF 382
            |:|||......::.||...|||.|..|||.......|..|:.||..|..|...:.||:.:..:|.
  Rat   315 EQLGDLFSKADDFPKASEAYQKQLHFAELLNRPDLELAVIHESLATTLGDMKDYHKAVHHYEEEL 379

  Fly   383 ELNQDAPSEAFTTLCTIAEICEQQSHPFWTVHDVYQKALRQADKAGSCSDKLVKIAMVRLRRLML 447
            .|.:....|...|...|....|:....:..:...:|||...|.:|          ...:|:|.:|
  Rat   380 RLRKGNALEEAKTWFNIGLAREEAGDAYELLAPCFQKAFGCAQQA----------QRYQLQRQIL 434

  Fly   448 KH--NMQVLVENLEADAT---------AKGIDLDQEESVGDDEEESDGGGTAVQQNTPDWDDDFD 501
            :|  .:|:.::..||..|         ||..:.::||...::||.|:...|:..:.:...||   
  Rat   435 QHLYTVQLKLQPQEARDTEIRLQELSMAKDTEEEEEEEEEEEEEASEALETSEMELSESEDD--- 496

  Fly   502 LATLTDSDASDLDETEKPRPQRTTRGNRTLVI---KKNNKGETQLHQACISGNLELVRRLIDQGH 563
                .|..:..|:|.|:.:.....|....|.:   ::|:.|||.||:|||.|.|..|:.|:.|||
  Rat   497 ----ADGLSQQLEEEEELQGCVGRRKINKLHLQWNRRNDMGETLLHRACIEGQLRRVQDLVKQGH 557

  Fly   564 TVNVRDHAGWLPLHEACNHGYREIVELLLDKGAASAINDKGGTSCDGITPLFDACSNGFLDVAEL 628
            .:|.||:.||.|||||||:|:.|||..|||.||  |::|.||..|||||||.||.:.|..:||||
  Rat   558 PLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGA--AVDDPGGQGCDGITPLHDALNCGHFEVAEL 620

  Fly   629 LLDRGADATVRTDYNETCIAGLDKWRQGAQL----VDGEQAQYAQLRERLLRTLSKVGICS---- 685
            |::|||..|:||....:.:..|.:|   .:|    :|.|..|.|...||.|:..|. |..|    
  Rat   621 LIERGASVTLRTRKGLSPLETLQQW---VKLYFRDLDLETRQKAASMERRLQMASS-GQASHSSP 681

  Fly   686 -----------DKNARPLTNFNAKRISREERGSMSEEEDEEEALHES-----NRRSLSHNRSGSE 734
                       |....|.::...|..|...|...:.....:..|.|:     ..|...|..:.|.
  Rat   682 ALQTIPNNHLFDPETSPPSSPCPKPPSYTPRPPEASPAPAKVFLEETVSAVCRPRKNRHRPASSS 746

  Fly   735 YGAKKSKSSTQPSASKEYRSVMAHLKRPNRLNDDPPSTSTLNKHKRNAFLSEDEVDADNWLIDDV 799
            ..::....:|.|....:.|  :.|..:........||.|      |...:|.....|....|..|
  Rat   747 SSSEDDDDNTNPCRPSQKR--LRHSTQQGEAKTPDPSKS------RETAISSACRAAYQAAIRGV 803

  Fly   800 GPERKRKRINSGDLSRRTSKENFQDTALSLPANWEDDLLQATPENEYSQRQKQMRKLTLSRSSSM 864
            |..:.|:.:.|  |.|.:::.....|||             .||.|:...:.......|:|||  
  Rat   804 GSAQSRRLVPS--LPRGSNEVPAPKTAL-------------IPEEEFLAEEWLEVDTPLTRSS-- 851

  Fly   865 SSNHSSSATSSRKKHQATLLDSGFSRFRSESPLGSESSQDG----TTSLISVRTIEPDSTTSTIQ 925
            ||:..|::.|..::..|        |.|:.:.....:|.||    |.:..:..|.||...:|   
  Rat   852 SSSRPSTSISDYERCPA--------RPRTRAKQSRPASLDGWCTRTKAADASLTAEPTENSS--- 905

  Fly   926 VLISPAKSSPIK-----------VQATPVLATTVSFKVKIQDELLLVPIERKKLQDINIRWLAEE 979
               .|..:.|.|           ||..|     :..:|:|||.|.|:|:....:.  ::.||||:
  Rat   906 ---MPRTTGPNKENCAAGQPLLLVQPPP-----IRVRVQIQDNLFLIPVPHSDVH--SVAWLAEQ 960

  Fly   980 AGRRYNKLTGLTPLLRLKTADGFAYEETDPVSVALEQN-MLMASILDWKISPLSQRYEEMCLQMQ 1043
            |.:||.:..||.|.|.|: .||......||:...|:.| .:||.:..|.:.||..||...|..:.
  Rat   961 AAQRYFQTCGLLPRLTLR-KDGALLAPQDPIPDVLQSNDEVMAEVTSWDLPPLKDRYRRACQSLG 1024

  Fly  1044 KTVDNKVKLLLERSQNNNMLELSGLWMRAEKTEPIFKAL-LHQARLTVLDLSCNFIGNEGCQQLA 1107
            :....:|...:|...::.......|.:...:..|:.:|| ||.| |..|.||.|.:|:....:|.
  Rat  1025 QGEHQQVLQAMEHQSSSPSFSACSLALCQAQLTPLLRALKLHTA-LRELRLSGNRLGDPCATELL 1088

  Fly  1108 KSLPTLLQLKALRLQCNAIGSHGLEALLCGQ-GMDKLELLEELNLNQNPLGNASVRILSKYCASP 1171
            .:|.|:..|..|.|..|.:|..||..|:.|. |....:.:|||:|:.||||:.        ||..
  Rat  1089 ATLGTMPNLVLLDLSSNHLGPEGLRQLVEGSLGQTAFQNVEELDLSMNPLGDG--------CAQA 1145

  Fly  1172 AGQAL-TC-----LQLAQCELTELQDFDLGFN-------------------KLTRFDISFNQLTQ 1211
            ....| ||     |:|..|          ||:                   .|....:|:|.|..
  Rat  1146 LASLLRTCPVLRTLRLQAC----------GFSPSFFLSHQAALGSAFKDAEHLKTLSLSYNTLGA 1200

  Fly  1212 QSVRRLTDQLNSCRLEQLNLSYVRWPLDDASGFALSERLVTLFEGGTCERFVGVQLAGCGLNDAH 1276
            .::.|:...|.:|.|..|.||.|   ....|..:|.|.::.......|........|.| |:|..
  Rat  1201 PALARVLQSLPTCTLLHLELSSV---AASKSNSSLIEPVIKYLTKEGCALAHLTLSANC-LSDKA 1261

  Fly  1277 MYNISQHLAKAKQLQMLDISDNSNLSGTTLGYI---LDELPQ---LRDLLAVNCTNLLD-DIRLQ 1334
            :..:|:.|.....|..||:|.|..:|...|..:   |.|.||   ..||...:....|: |:..:
  Rat  1262 VRELSRCLPSCPSLTSLDLSANPEVSCAGLEELLSALQERPQGLSFFDLSGCSIQGPLNSDLWDK 1326

  Fly  1335 KLEQLKQL 1342
            .|.||::|
  Rat  1327 ILSQLQEL 1334

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7457NP_648150.1 LapB 28..385 CDD:442196 106/364 (29%)
TPR repeat 163..191 CDD:276809 8/27 (30%)
TPR repeat 196..233 CDD:276809 4/36 (11%)
TPR repeat 238..273 CDD:276809 11/34 (32%)
TPR repeat 316..342 CDD:276809 9/25 (36%)
TPR repeat 347..384 CDD:276809 9/36 (25%)
TPR repeat 389..422 CDD:276809 7/32 (22%)
ANKYR <532..>645 CDD:440430 62/115 (54%)
ANK repeat 539..569 CDD:293786 16/29 (55%)
ANK repeat 571..604 CDD:293786 20/32 (63%)
ANK repeat 609..639 CDD:293786 18/29 (62%)
RNA1 <1038..1233 CDD:444072 57/221 (26%)
leucine-rich repeat 1088..1115 CDD:275381 9/26 (35%)
leucine-rich repeat 1116..1170 CDD:275381 19/54 (35%)
leucine-rich repeat 1199..1225 CDD:275381 6/25 (24%)
leucine-rich repeat 1226..1261 CDD:275381 9/34 (26%)
leucine-rich repeat 1262..1289 CDD:275381 6/26 (23%)
leucine-rich repeat 1290..1315 CDD:275381 9/27 (33%)
TonslXP_008763809.1 TPR 25..>234 CDD:440225 64/218 (29%)
TPR repeat 27..55 CDD:276809 11/27 (41%)
TPR repeat 66..96 CDD:276809 11/29 (38%)
TPR repeat 101..131 CDD:276809 14/38 (37%)
TPR repeat 163..190 CDD:276809 8/26 (31%)
TPR repeat 195..237 CDD:276809 6/42 (14%)
TPR 197..450 CDD:440225 67/268 (25%)
TPR repeat 242..270 CDD:276809 11/29 (38%)
TPR repeat 316..339 CDD:276809 8/22 (36%)
TPR repeat 351..381 CDD:276809 9/29 (31%)
TPR repeat 390..417 CDD:276809 4/26 (15%)
ANKYR <527..>639 CDD:440430 62/113 (55%)
ANK repeat 532..563 CDD:293786 16/30 (53%)
ANK repeat 565..596 CDD:293786 20/32 (63%)
ANK repeat 601..631 CDD:293786 18/29 (62%)
RNA1 <1059..1335 CDD:444072 83/299 (28%)
leucine-rich repeat 1069..1096 CDD:275380 9/26 (35%)
leucine-rich repeat 1097..1128 CDD:275380 10/30 (33%)
leucine-rich repeat 1129..1151 CDD:275380 10/29 (34%)
leucine-rich repeat 1156..1187 CDD:275380 5/40 (13%)
leucine-rich repeat 1188..1212 CDD:275380 6/23 (26%)
leucine-rich repeat 1213..1246 CDD:275380 9/35 (26%)
leucine-rich repeat 1247..1274 CDD:275380 6/27 (22%)
leucine-rich repeat 1275..1297 CDD:275380 7/21 (33%)
leucine-rich repeat 1298..1325 CDD:275380 8/26 (31%)

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