DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7457 and Bard1

DIOPT Version :9

Sequence 1:	NP_001303376.1	Gene:	CG7457 / 38865	FlyBaseID:	FBgn0035812	Length:	1405	Species:	Drosophila melanogaster
Sequence 2:	NP_031551.1	Gene:	Bard1 / 12021	MGIID:	1328361	Length:	765	Species:	Mus musculus

Alignment Length:	684	Identity:	149/684 - (21%)
Similarity:	231/684 - (33%)	Gaps:	228/684 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 VKVCQTLDELVLTSSVDYAKLKGLYEKLGDGCCHLMNYEKALTYYQKMLENAELNQESGK----- 352
            :|:.:.||.::..||    ||:.|.....|        .|..|....:..:||..:.|.|
Mouse    89 LKINRQLDSMIQLSS----KLQNLLHDNKD--------SKDNTSRASLFGDAERKKNSIKMWFSP 141

  Fly   353 -----SLVPIYVSLYQTYRDNGQFDKALEYLWKEFELNQDAPSEAFTTLCTIAEICEQQSHPFWT 412
                 ..|...||: ||.....:.|||.|....||.  ...|..|.......|.....:.||..:
Mouse   142 RSKKVRYVVTKVSV-QTQPQKAKDDKAQEASMYEFV--SATPPVAVPKSAKTASRTSAKKHPKKS 203

  Fly   413 VHDV-YQKALR--------------QADKAGSCSDKLVKIAMVRLRRLMLKHNMQVLVENLEADA 462
            |..: .::.||              :.:|..|||    :|.::...|:           |.|.|.
Mouse   204 VAKINREENLRPETKDSRFDSKEELKEEKVVSCS----QIPVMERPRV-----------NGEIDL 253

  Fly   463 TAKGIDLDQE-------------------ESVGDDEE---------------------------- 480
            .|.|..::.|                   ::|..:||
Mouse   254 LASGSVVEPECSGSLTEVSLPLAEHIVSPDTVSKNEETPEKKVCVKDLRSGGSNGNRKGCHRPTT 318

  Fly   481 -ESDGGGTAVQQNT---------------------PDWDDDFDLATLTDSDASDLDETE----KP 519
             .||..|:.:...:                     |......|:.....|:||| |...    .|
Mouse   319 STSDSCGSNIPSTSRGIGEPALLAENVVLVDCSSLPSGQLQVDVTLRRKSNASD-DPLSLSPGTP 382

  Fly   520 RPQRTTRGNRTLVI--------------KKNNKGETQLHQACISGNLELVRRLIDQGHTVNVRDH 570
            .|......:|.::.              |:|::|||.||.|.|.|::..|..|:..|:..||:||
Mouse   383 PPLLNNSTHRQMMSSPSTVKLSSGMPARKRNHRGETLLHIASIKGDIPSVEYLLQNGNDPNVKDH 447

  Fly   571 AGWLPLHEACNHGYREIVELLLDKGAASAINDKGGTSCDGITPLFDACSNGFLDVAELLLDRGAD 635
            |||.||||||:||:.::|||||...|  .:|..|   ....:||.||..:|.:|:.::||..||.
Mouse   448 AGWTPLHEACSHGHLKVVELLLQHNA--LVNTPG---YQNDSPLHDAVKSGHIDIVKVLLSHGAS 507

  Fly   636 ATVRTDYNETCIAGLDKWRQGAQLVDGEQAQYAQLRERLLRTLSKVGICSDKNARPLTNFNAKRI 700
            .      |...|.|                            :..|....::|.|.|.
Mouse   508 R------NAVNIFG----------------------------VRPVDYTDNENIRSLL------- 531

  Fly   701 SREERGSMSEEEDEEEALHESNRRSLSHNRSG----------SEYGAKKSKSSTQPSASK--EYR 753
                   :..||:|..:..:.:..:....::|          |:.....||..|...|.|  |:.
Mouse   532 -------LLPEENESFSTSQCSIVNTGQRKNGPLVFIGSGLSSQQQKMLSKLETVLKAKKCMEFD 589

  Fly   754 SVMAHLKRPNRLNDDPPSTSTLNKHKRNAFLSEDEVDADNWL---IDDVGPERKRK-RINSGDLS 814
            |.:.|:..|     |..:.|||.  .....||...:...:|:   :|....|::.| .:..|...
Mouse   590 STVTHVIVP-----DEEAQSTLK--CMLGILSGCWILKFDWVKACLDSKVREQEEKYEVPGGPQR 647

  Fly   815 RRTSKEN-----FQDTALSLPANWE----DDLLQ 839
            .|.::|.     |......|..|::    ||||:
Mouse   648 SRLNREQLLPKLFDGCYFFLGGNFKHHPRDDLLK 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7457	NP_001303376.1	TPR_12	21..95	CDD:290160
		TPR	68..387	CDD:223533	26/103 (25%)
		TPR repeat	163..191	CDD:276809
		TPR repeat	196..233	CDD:276809
		TPR repeat	238..273	CDD:276809
		TPR repeat	316..342	CDD:276809	4/25 (16%)
		TPR repeat	347..384	CDD:276809	13/46 (28%)
		TPR repeat	389..422	CDD:276809	6/33 (18%)
		ANK	535..647	CDD:238125	46/111 (41%)
		ANK repeat	539..569	CDD:293786	13/29 (45%)
		Ank_2	543..639	CDD:289560	41/95 (43%)
		ANK repeat	571..604	CDD:293786	18/32 (56%)
		ANK repeat	609..639	CDD:293786	10/29 (34%)
		LRR_RI	1063..1360	CDD:238064
		leucine-rich repeat	1088..1115	CDD:275381
		leucine-rich repeat	1116..1170	CDD:275381
		leucine-rich repeat	1199..1225	CDD:275381
		leucine-rich repeat	1226..1261	CDD:275381
		leucine-rich repeat	1262..1289	CDD:275381
		leucine-rich repeat	1290..1315	CDD:275381
Bard1	NP_031551.1	Required for BRCA1 binding. /evidence=ECO:0000250	20..113		8/27 (30%)
		zf-RING_6	35..99	CDD:291501	3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..229		7/45 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..328		3/28 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..410		7/41 (17%)
		Ank_4	391..436	CDD:290365	12/44 (27%)
		ANK	412..532	CDD:238125	52/172 (30%)
		ANK 1	415..447		13/31 (42%)
		ANK repeat	415..446	CDD:293786	13/30 (43%)
		Ank_2	420..512	CDD:289560	42/102 (41%)
		ANK 2	448..480		19/36 (53%)
		ANK repeat	448..479	CDD:293786	18/32 (56%)
		ANK 3	481..513		11/37 (30%)
		ANK repeat	481..512	CDD:293786	11/36 (31%)
		ANK 4, degenerate	514..534		5/61 (8%)
		Flexible linker. /evidence=ECO:0000250	542..546		0/3 (0%)
		BRCT	558..628	CDD:214602	17/76 (22%)
		BRCT	657..755	CDD:214602	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842450
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930