DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7457 and tonsl

DIOPT Version :9

Sequence 1:	NP_001303376.1	Gene:	CG7457 / 38865	FlyBaseID:	FBgn0035812	Length:	1405	Species:	Drosophila melanogaster
Sequence 2:	XP_031759614.1	Gene:	tonsl / 100158623	XenbaseID:	XB-GENE-5939806	Length:	1428	Species:	Xenopus tropicalis

Alignment Length:	1485	Identity:	405/1485 - (27%)
Similarity:	650/1485 - (43%)	Gaps:	244/1485 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EEKRYLKRKEKARSDGNRDQVAVSCNQLGDFYNQQGKYTDAVREYVQEAQIYASMGKELETAKAK 66
            |.::..|.|.||:...|..:.|..|||||:...:.|.:.:|:.|:.||..|...:...:..|.|.
Frog     5 EIRQLEKAKCKAQRSHNLKEEASVCNQLGELLARNGCFREAIEEHRQERMICEGLSDVIGCAVAN 69

  Fly    67 RMVGEMYTLLCDYDAAKDHINDYLKIAKRLKNQVEEQRAYATLGRVHLLHGQSLADSSASGSMEQ 131
            |.:||.:..|.:::||..|...:|.:|:.:.:.:|||||.||:||.:|.    :.|   :|..|:
Frog    70 RKIGECFAELGNFEAALKHQKLHLDLARSVSSDIEEQRALATIGRTYLY----MCD---AGRAEE 127

  Fly   132 LK-LAEKNFLRSLLLIKD-LSGQISKLEQLDMQARCYLNIGVVKEHMEAFQESIEYIDKAIKISK 194
            .| .||:.||:||.::.: |.|::...|..:|:||.|||:|::.:.:....:...||.|::.||:
Frog   128 AKGPAEEAFLKSLAIVDERLEGKVCVRELNEMRARLYLNLGLLYDQLRRTDKCSFYIRKSVFISE 192

  Fly   195 THELWDLTHLCYISMSLLYICKKNDATAALRFCNMALEVAKRFPNK-VKKICETLITKAEILIKA 258
            .::|::..:....:::.::: :..:.:.|:|....|.|.|:|..:| ::..|.:.|.:|  |:..
Frog   193 QNQLYEDLYRANFTLAGIHM-RNKEHSKAIRCWEAARECARRMRDKHMESECYSSIGQA--LLTL 254

  Fly   259 GDFASAKQILTKAYKKNTPDENDRVNIEKQLRIVVKVCQTLDELVLTSSVDYAKLKGLYEKLGDG 323
            ||.::.|:.|.|::...:.|..||..:.:.|:..::.|:..:.|...|..|......|||:|||.
Frog   255 GDLSAGKRSLKKSFLLGSRDLTDRDIVRRNLKYAIRGCRLEESLSELSEEDQQGALCLYEQLGDL 319

  Fly   324 CCHLMNYEKALTYYQKMLENAELNQESGKSLVPIYVSLYQTYRDNGQFDKALEYLWKEFELNQDA 388
            .|.:..|.:|:..|:..|..||......:.|..|:|||..|:.|.....:|:::...|.||.:..
Frog   320 YCKVGCYTRAIEDYRMQLNCAETLGRPERELAVIHVSLATTFTDLKDHVQAVKHYRAELELRKGN 384

  Fly   389 PSEAFTTLCTIAEICEQQSHPFWTVHDVYQKALRQADKAGSCSDKLVKIAMVRLRRLMLKHNMQV 453
            |||...|...||:..|:.......:......||:.|.:||..:          |:|.:|:..:.|
Frog   385 PSEECKTWMNIAQSYEEDGRRHTDIQSCLSNALQCAQRAGEAA----------LQRKVLRQLLAV 439

  Fly   454 ---LVENLEADATAKGIDLDQEESVGDDEEESDGGGTAVQQNTPDWDDDFDLATLTDSDASDLDE 515
               |.:....|..||..:|.........|||.:     ::.:.|..:.|.:|:...|.:  ||:.
Frog   440 QEKLGDPEVGDTEAKLQELCSGPGGESSEEEEE-----MENSEPLQESDLELSQSEDDE--DLEG 497

  Fly   516 TEK--PRPQRTTRGNRTLVIKKNNKGETQLHQACISGNLELVRRLIDQGHTVNVRDHAGWLPLHE 578
            .||  |..:|..|.||     :|.||||.||:|||.||.:||:.||::||.::.||:.||.||||
Frog   498 YEKLVPGKRRVNRWNR-----RNEKGETVLHRACIEGNAKLVKTLIEKGHPLSPRDYCGWTPLHE 557

  Fly   579 ACNHGYREIVELLLDKGAASAINDKGGTSCDGITPLFDACSNGFLDVAELLLDRGADATVRTDYN 643
            |.|||:.|||||||:|||  .|||.||..|:|||||.||.|:|...||:||:.|||..|::....
Frog   558 AANHGHLEIVELLLEKGA--NINDPGGPLCEGITPLHDALSSGNFHVAQLLIRRGASVTLKNAKG 620

  Fly   644 ETCIAGLDKW--RQGAQLVDGEQAQYAQLRERLLRTLSKVGICS--------------------- 685
            ...:..|..|  ..|..| |.|..|..:..|.|||......:.:
Frog   621 VAPLGSLQDWIGTYGKHL-DQETRQNCKETESLLREALAGRVAAAPSRPESLQDSELFDAEGSQP 684

  Fly   686 -------DKNARPLTNFNAKRISREERGS------MSEEEDEEEALHESNRRSLSHNRSGSEYGA 737
                   |..|.|......:...|.:|.:      :|..|:|::...:::....:..|:|.:.|
Frog   685 DSLAPSWDSRADPQRTVPQRERRRNDRATRPSNIQLSALEEEQDDFVDTSPPICASPRAGGDMG- 748

  Fly   738 KKSKSSTQPSASKEYRSVMAHL----KRPNRLNDDPPSTSTLNKHKRNAFLSEDEVDADN----- 793
                     .:::.:..::..|    |||......|.:.|.|.:...      ||.:|:|
Frog   749 ---------FSTETFEQLLTPLKPVKKRPRFEGKRPLADSALGREHL------DETEAENPPFPP 798

  Fly   794 ---WLIDDVGPERKRKRINS-GDLSRRTSKENFQDTALSLP----------------ANWEDDLL 838
               ....|.|.|:.:|.|.. |....|...::......|.|                .:|.:|.|
Frog   799 VHQIRAPDCGMEQYQKAIRDLGSAKSRLLTQSLAQPISSTPDTLSKMALVPSEEYLDDDWLEDDL 863

  Fly   839 QATPENEYSQRQKQMRKLTLSRSSSMSSNHSSSATSSRKKHQATLLDSGFSRFRSESPLGS---- 899
            |.||.:    |::|       |:.:.|.....|..||    |.|...:..||.|.:.|:.|
Frog   864 QETPRS----RKRQ-------RTFTQSIEEEESPVSS----QETEAPAQLSRVREKQPMRSLSVS 913

  Fly   900 --ESSQDGTTSLISVRTIEPDSTTSTIQ------------------------VLISPAKSSPIKV 938
              .|.|...|.::. ||: ...|.:::|                        .|:||....|..|
Frog   914 NKRSRQTKLTQIVD-RTV-VGRTKNSVQNNAFIPRVQESAPTRGLGSAKDSSGLLSPVILQPAGV 976

  Fly   939 QATPVLATTVSFKVKIQDELLLVPIERKKLQDINIRWLAEEAGRRYNKLTGLTPLLRLKTADGFA 1003
            ...|.:...:..:|::||.:.|:||.....:...|.|||:||.:||.:..||.|.|.|| .:|..
Frog   977 VLNPTVPPPIRVRVRVQDNIFLIPIPHSDSETREISWLADEAAQRYYQSCGLLPRLTLK-KEGAL 1040

  Fly  1004 YEETDPVSVALEQN-MLMASILDWKISPLSQRYEEMCLQMQKTVDNKVKLLLERSQNNNMLELSG 1067
            ....|.|...|:.| .::|.:..|.:.||:.||.:.|..:....::.:...|||.:::..|..|.
Frog  1041 LAPQDLVLHVLQSNEEVLAEVHSWDLPPLTDRYRKACQSLAVEENHLLVRALERQESSQCLTFSH 1105

  Fly  1068 LWMRAEKTEPIFKALLHQARLTVLDLSCNFIGNEGCQQLAKSLPTLLQLKALRLQCNAIGSHGLE 1132
            |.:|.....|:.:||..|..|..|.||.|.:|:....:|...|.|:..|..|.|..|.:...|:.
Frog  1106 LSLRPRDLGPLLRALKLQNSLRQLHLSGNLLGDTEAAELLAVLSTMPNLTHLNLSSNRLTHEGIR 1170

  Fly  1133 ALLCGQGMDK-LELLEELNLNQNPLGNA---SVRILSKYCASPAGQALTCLQLAQCELT------ 1187
            .|......|: .:.||.|:|:.|||||.   .:.:|.:.|     ..|:.|.|..|:|:
Frog  1171 KLANITQEDRPFKSLEHLDLSVNPLGNGLSQPLALLLRSC-----PVLSTLHLRGCQLSAKFLQQ 1230

  Fly  1188 -------------ELQDFDLGFN-----------------KLTRFDI----SFNQ---LTQQSVR 1215
                         .|:...|..|                 .|||.||    |.|:   |.:..||
Frog  1231 YRIQLAEAFRGAVHLKTLSLSHNPLGSTGLELVLKTLAPETLTRLDIQAVTSGNKEGLLIEPLVR 1295

  Fly  1216 RLTDQLNSCRLEQLNLSYVRWPLDDASGFALSERLVTLFEGGTCERFVGVQLAG------CGLND 1274
            .|:.  :.|.|..|:|:...  |.|.....|:..|      ..|...|.:.|:|      .|| :
Frog  1296 YLSQ--DGCVLSHLSLACNH--LTDGPALELARCL------PVCPSLVSLDLSGNPGIGADGL-E 1349

  Fly  1275 AHMYNISQHLAKAKQLQMLDISDNSNLSGTTLGYILDELPQLRDLLAVNCTNLLD 1329
            ..:..|.:...:...|.:...|....||.:.||.|...|.:.|  ||..|.:.:|
Frog  1350 CLLEGIGERSTEMADLNLAGCSIRGPLSTSCLGAISSSLCEFR--LASRCLSKMD 1402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7457	NP_001303376.1	TPR_12	21..95	CDD:290160	23/73 (32%)
		TPR	68..387	CDD:223533	92/321 (29%)
		TPR repeat	163..191	CDD:276809	9/27 (33%)
		TPR repeat	196..233	CDD:276809	4/36 (11%)
		TPR repeat	238..273	CDD:276809	10/35 (29%)
		TPR repeat	316..342	CDD:276809	10/25 (40%)
		TPR repeat	347..384	CDD:276809	9/36 (25%)
		TPR repeat	389..422	CDD:276809	8/32 (25%)
		ANK	535..647	CDD:238125	63/111 (57%)
		ANK repeat	539..569	CDD:293786	16/29 (55%)
		Ank_2	543..639	CDD:289560	58/95 (61%)
		ANK repeat	571..604	CDD:293786	23/32 (72%)
		ANK repeat	609..639	CDD:293786	17/29 (59%)
		LRR_RI	1063..1360	CDD:238064	82/320 (26%)
		leucine-rich repeat	1088..1115	CDD:275381	9/26 (35%)
		leucine-rich repeat	1116..1170	CDD:275381	18/57 (32%)
		leucine-rich repeat	1199..1225	CDD:275381	11/32 (34%)
		leucine-rich repeat	1226..1261	CDD:275381	8/34 (24%)
		leucine-rich repeat	1262..1289	CDD:275381	6/32 (19%)
		leucine-rich repeat	1290..1315	CDD:275381	8/24 (33%)
tonsl	XP_031759614.1	TPR	<1..229	CDD:223533	68/231 (29%)
		TPR repeat	26..60	CDD:276809	12/33 (36%)
		TPR repeat	65..95	CDD:276809	10/29 (34%)
		TPR repeat	107..155	CDD:276809	19/54 (35%)
		TPR repeat	161..195	CDD:276809	11/33 (33%)
		TPR repeat	200..230	CDD:276809	3/30 (10%)
		TPR repeat	241..266	CDD:276809	8/26 (31%)
		TPR_12	309..382	CDD:315987	24/72 (33%)
		TPR repeat	312..338	CDD:276809	10/25 (40%)
		TPR repeat	350..380	CDD:276809	9/29 (31%)
		TPR repeat	385..423	CDD:276809	10/37 (27%)
		ANK repeat	518..548	CDD:293786	16/29 (55%)
		Ank_2	522..617	CDD:403870	58/96 (60%)
		ANK repeat	550..581	CDD:293786	23/32 (72%)
		ANK repeat	586..617	CDD:293786	17/30 (57%)
		LRR_RI	1077..1340	CDD:423007	69/277 (25%)
		leucine-rich repeat	1126..1153	CDD:275380	9/26 (35%)
		leucine-rich repeat	1154..1184	CDD:275380	7/29 (24%)
		leucine-rich repeat	1185..1212	CDD:275380	11/31 (35%)
		leucine-rich repeat	1213..1244	CDD:275380	5/30 (17%)
		leucine-rich repeat	1245..1271	CDD:275380	3/25 (12%)
		leucine-rich repeat	1272..1299	CDD:275380	11/26 (42%)
		leucine-rich repeat	1304..1331	CDD:275380	8/34 (24%)
		leucine-rich repeat	1332..1351	CDD:275380	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7696
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H22754
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1848
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D37202at33208
OrthoFinder	1	1.000	-	-		FOG0007065
OrthoInspector	1	1.000	-	-		oto102196
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5939
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060