Protein Alignment GBP7 and gbp2

DIOPT Version :10

• Sequence 1: NP_997281.2
• Gene: GBP7 / 388646
• HGNCID: 29606
• Length: 638
• Species: Homo sapiens
• Sequence 2: NP_001072267.1
• Gene: gbp2 / 779720
• XenbaseID: XB-GENE-5828806
• Length: 591
• Species: Xenopus tropicalis
• Alignment Length: 584
• Identity: 287/584 - (49%)
• Similarity: 404/584 - (69%)
• Gaps: 9/584 - (1%)

Human     1 MASEIHMPGPVCLTEN-TKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKG 64
            |:::|||..|:||.|| .....|:|:||.:|||.||.|||||||||.||||||||||||||...|
 Frog     1 MSAQIHMKYPICLIENRNSNEFVINTEAEQILSQITDPVVVVAIVGKYRTGKSYLMNKLAGSKTG 65

Human    65 FPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYN 129
            |.||.|::|:||||||||||||.:|:|||:|||||||||:||.|.|:|.|||:|||||||:.|||
 Frog    66 FALGSTIQSKTKGIWMWCVPHPCQPSHTLVLLDTEGLGDVEKGDSKNDGWIFSLAVLLSSNLVYN 130

Human   130 SMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPI 194
            |||||:||::||||||||||.||:.||.|:..: ::|.||...||.|.|.||||:|.|:|||..:
 Frog   131 SMGTIDHQSMEQLHYVTELTNLIKIKSNPKEGK-DESGEFKRIFPSFTWCVRDFSLILELDGKKV 194

Human   195 TEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLH-VEEVREDQLD 258
            |||:||.|:|:|..|.:.:.|:.|.|||.|.|:|...||||||:|.:.:.  || :||::|..|:
 Frog   195 TEDDYLMNSLRLKKGTDRKTQDFNLPRECILHYFHSHKCFVFDQPTSSRN--LHRLEELQEQNLE 257

Human   259 SNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMAVLAQCEN 323
            ..|..|::.||.||......|||..|:||||..|..|...|::.|.||:.||:|||:..|:..||
 Frog   258 ETFVEQAQKFCGYIHRDGIAKTLPGGLLVTGRMLAHLTSLYIETIMSGSVPCMENAILALSVIEN 322

Human   324 SAAVQRAANHYSQQMAQQV-RFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTM 387
            :.|||.|...|...|.:.: ||||:||||.|.:|...|:||:.||::.||.|::|:|||:..:.:
 Frog   323 TGAVQDALAKYETCMNEHLPRFPTETLQEFLHLHQGSEKEALEVFLKRSFNDENQDFQKEFKNLL 387

Human   388 EKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRK 452
            :.|.::|..:||..|.:.||..:::|||.|.:.||:|.|..||||.::|:.|..|.::|...|.|
 Frog   388 DNKMKEFSERNERESTERCQTIIQKLSESLEQRISQGEFSKPGGHKLFLKEKMTIMEEYNTTPHK 452

Human   453 GVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMME 517
            |:|:.||||.|:.::...|.:|||:|::|||.||.||..||:...||:::::|.:|:|..|:.||
 Frog   453 GLKSLEVLQEFISNKKATEAAILQADESLTAKEKEIAESQAETAEAERQRQILEEKEKYLQESME 517

Human   518 AQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEI---NRL 578
            .|::||:::...|.:|||.:|:..:.|..::::.|::....:||.||:.....|..||   ||:
 Frog   518 NQKKSFEQHEKMLIEKMEADRQKLIAENGRVIAQKLQEQNAMLTAGFQSKVNDLQREIADLNRM 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP7	NP_997281.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..310		178/310 (57%)
		GBP	18..281	CDD:460516	156/263 (59%)
		GBP_C	283..579	CDD:460721	120/300 (40%)
		Interaction with the CYBA-CYBB complex. /evidence=ECO:0000250|UniProtKB:Q91Z40	311..638		107/272 (39%)
		C-terminal tail, required for its localization to cytoplasmic vesicle. /evidence=ECO:0000250|UniProtKB:Q91Z40	590..638
gbp2	NP_001072267.1	GBP	20..280	CDD:460516	156/262 (60%)
		GBP_C	282..579	CDD:460721	118/296 (40%)