Protein Alignment GBP7 and Gbp7

DIOPT Version :10

• Sequence 1: NP_997281.2
• Gene: GBP7 / 388646
• HGNCID: 29606
• Length: 638
• Species: Homo sapiens
• Sequence 2: NP_001396037.1
• Gene: Gbp7 / 685067
• RGDID: 1583235
• Length: 627
• Species: Rattus norvegicus
• Alignment Length: 623
• Identity: 432/623 - (69%)
• Similarity: 517/623 - (82%)
• Gaps: 0/623 - (0%)

Human     1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGF 65
            |||...|..|:||.||....|.||.:|:.||..|||||||||||||||||||||||:|||:|.||
  Rat     1 MASASSMEAPICLVENENEELRVNPKAINILERITQPVVVVAIVGLYRTGKSYLMNRLAGQNHGF 65

Human    66 PLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNS 130
            .||.||:||||||||||||||.||..||:|||||||||:||.|||:|||||||||||||:|||||
  Rat    66 NLGTTVRSETKGIWMWCVPHPCKPKFTLVLLDTEGLGDVEKCDPKNDSWIFALAVLLSSTFVYNS 130

Human   131 MGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPIT 195
            |.|||||||||||||||||||||.||.||.:|::||.|||.|||||||.||||.|||||||..||
  Rat   131 MSTINHQALEQLHYVTELTELIRTKSTPRSEEIDDSDEFVGFFPDFIWVVRDFVLELKLDGRVIT 195

Human   196 EDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQLDSN 260
            .|||||||||||.|::.:.||||.|||.||||||::|||||||||.:|:||:||||:.||:||.|
  Rat   196 ADEYLENALKLIPGRSLKAQNSNLPRECIRHFFPRRKCFVFDRPIKEKELLVHVEEMPEDELDHN 260

Human   261 FQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMAVLAQCENSA 325
            |:.||..||||||::||.|||:|||:|.||||..||.||:|||||||.||||||:..|||.||||
  Rat   261 FREQSNVFCSYIFSNAKAKTLKEGIMVNGNRLATLVTTYVDAINSGAVPCLENAVTTLAQRENSA 325

Human   326 AVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKK 390
            |||:||.|||:||||::|.||||||||||||:.||:||||||||:||||::|||||.||.|:.:|
  Rat   326 AVQKAAEHYSEQMAQRLRLPTDTLQELLDVHSACEKEAIAVFMEHSFKDENQEFQKNLVVTIVEK 390

Human   391 KEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVK 455
            :|||..|||.||..:|||||.:|||.|.||||.|.|.|||||::||||:||:||||..|||||||
  Rat   391 REDFSRQNEAASLSHCQAELDKLSESLRESISCGAFSVPGGHSLYLEARKKVEQDYEQVPRKGVK 455

Human   456 ADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQE 520
            |:.|||||||||:|||.||||||||||..:||:..::|:|||||||||||||||||.||:||:||
  Rat   456 ANHVLQSFLQSQIVIENSILQSDKALTVNQKAMEVERAQKEAAEKEQELLRQKQKELQQVMESQE 520

Human   521 RSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAA 585
            ||::|||.||.:|||.||:|.:.:..:||:||:||.||:|.||||..:|:::.||::|::||:..
  Rat   521 RSYKENIVQLHEKMETERKNILEKQEEMLAHKLKVQEEMLNEGFKRKYEAMDSEISQLQKQIQQN 585

Human   586 ENEEPSVFSQILDVAGSIFIAALPGAAKLVDLGMKILS 623
            :.:..|:.:||.|..|::.::.|||..||..||:||||
  Rat   586 KEQNSSLAAQIFDGFGNVLMSVLPGTGKLFGLGLKILS 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP7	NP_997281.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..310		229/308 (74%)
		GBP	18..281	CDD:460516	199/262 (76%)
		GBP_C	283..579	CDD:460721	203/295 (69%)
		Interaction with the CYBA-CYBB complex. /evidence=ECO:0000250|UniProtKB:Q91Z40	311..638		201/313 (64%)
		C-terminal tail, required for its localization to cytoplasmic vesicle. /evidence=ECO:0000250|UniProtKB:Q91Z40	590..638		16/34 (47%)
Gbp7	NP_001396037.1	GBP	18..281	CDD:460516	199/262 (76%)
		GBP_C	283..579	CDD:460721	203/295 (69%)