DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP7 and gbp2

DIOPT Version :9

Sequence 1:	NP_997281.2	Gene:	GBP7 / 388646	HGNCID:	29606	Length:	638	Species:	Homo sapiens
Sequence 2:	XP_699217.2	Gene:	gbp2 / 570622	ZFINID:	ZDB-GENE-070912-618	Length:	627	Species:	Danio rerio

Alignment Length:	630	Identity:	283/630 - (44%)
Similarity:	399/630 - (63%)	Gaps:	9/630 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASEIHMPGPVCLTENTK-GHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKG 64
            ||...||..||||.||.: |.|.|..||.:||..|.:|||||::|||||||||||||:||||..|
Zfish     1 MAFGRHMSAPVCLIENDEFGKLCVKKEAKDILDEINEPVVVVSVVGLYRTGKSYLMNRLAGKQSG 65

Human    65 FPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYN 129
            |.||.|::|:||||||||||||.|..|||:|||||||||::|.|.:.|:|||.|||||||:.|||
Zfish    66 FALGSTIESKTKGIWMWCVPHPYKKGHTLVLLDTEGLGDVDKGDERHDTWIFCLAVLLSSALVYN 130

Human   130 SMGTINHQALEQLHYVTELTELIRAKSCPRPDEVED---SSEFVSFFPDFIWTVRDFTLELKLDG 191
            |:|.|::.|||:|||||||||.||.|:  ..:||||   |:||:..||.|:|.|||||||||:..
Zfish   131 SLGVIDNMALEKLHYVTELTENIRVKA--EGNEVEDEDESAEFMRVFPSFVWAVRDFTLELKMGD 193

Human   192 HPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQ 256
            .|||.|||||:|||...|.:|||...|.||..:|.||..:|||||.||.:.:. :..:|::.|::
Zfish   194 KPITSDEYLESALKPKKGNSPQIAQYNLPRRCLREFFAPRKCFVFPRPASTQD-MKRMEDLTEEE 257

Human   257 LDSNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMAVLAQC 321
            |||.|..|:..|||||:...:.||::.|..:||..||.|.|.|::||.||..||||||:..||:.
Zfish   258 LDSEFLQQANTFCSYIYNSTEPKTVKGGRTITGTALGNLAEVYVEAIRSGKVPCLENAVVSLAKI 322

Human   322 ENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDT 386
            :|..||::|...|..:|....:||.|. :||..:|.:.|::||..|:..||.|..|.:|::|:..
Zfish   323 QNVRAVEQALQIYMTEMLSMAQFPLDP-EELSSIHTLAEKKAIEEFINMSFSDNDQIYQQELMGK 386

Human   387 MEKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPR 451
            :..:.:|...||.:||...||..|:.:.:.|..:||.|::..|||:..|.....::...|....:
Zfish   387 IHNEYQDLCQQNHQASLMQCQEVLEDVFDPLEMNISNGSYLRPGGYREYRALLAQLTSSYRARTK 451

Human   452 KGVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMM 516
            ..:.::|||..||:.:..:...|||:|::|:|.|:....:..|.|..::.|..|.::.:.|:|..
Zfish   452 SQIMSEEVLCMFLKGKEDVGNMILQADESLSAAEQEKEVQMLKNEILQQRQRGLEEQNRLQEQAF 516

Human   517 EAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQ 581
            :..||:.||::.|:..:||||:|...|:..::|..|:|..|.||.:||:|....:.:|||.||..
Zfish   517 KDMERTHQEHVNQIVHQMEREQERIRRDNERVLEAKLKEREALLKQGFEEEASRMQKEINSLKTD 581

Human   582 IEAAENEEPSVFSQILDVAGSIFIAALPG-AAKLVDLGMKILSSL 625
            :...|..:||...::||..|:.....||| ..|...:|:..||.|
Zfish   582 MSKQEESKPSTMRKVLDGIGTAATLFLPGFIPKAAGIGLSFLSRL 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP7	NP_997281.2	GTPase domain (Globular). /evidence=ECO:0000250	1..310		179/312 (57%)
		GBP	18..281	CDD:280433	156/266 (59%)
		GBP_C	283..579	CDD:202427	100/295 (34%)
		GBP_C	289..579	CDD:293879	98/289 (34%)
		coiled coil	548..559	CDD:293879	4/10 (40%)
		coiled coil	568..579	CDD:293879	3/10 (30%)
gbp2	XP_699217.2	P-loop_NTPase	20..281	CDD:304359	155/263 (59%)
		GBP_C	284..579	CDD:202427	100/295 (34%)
		GBP_C	290..579	CDD:293879	98/289 (34%)
		coiled coil	548..559	CDD:293879	4/10 (40%)
		coiled coil	568..579	CDD:293879	3/10 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I6643
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	565	1.000	Inparanoid score	I5681
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55037
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	1	1.000	-	-		mtm6791
orthoMCL	1	0.900	-	-		OOG6_100467
Panther	1	1.100	-	-	O	PTHR10751
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980