Protein Alignment GBP7 and Gbp3

DIOPT Version :10

• Sequence 1: NP_997281.2
• Gene: GBP7 / 388646
• HGNCID: 29606
• Length: 638
• Species: Homo sapiens
• Sequence 2: XP_006501782.1
• Gene: Gbp3 / 55932
• MGIID: 1926263
• Length: 680
• Species: Mus musculus
• Alignment Length: 624
• Identity: 438/624 - (70%)
• Similarity: 519/624 - (83%)
• Gaps: 1/624 - (0%)

Human     2 ASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFP 66
            |||..|..|:||.||.|..|.||.||:.||..|.||:||||||||||||||||||:|||:|.||.
Mouse    56 ASEWTMEAPICLVENWKNQLTVNLEAIRILEQIAQPLVVVAIVGLYRTGKSYLMNRLAGRNHGFS 120

Human    67 LGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSM 131
            ||.||:||||||||||||||:||.|||:|||||||||:||.|||:|||||||||||||:||||||
Mouse   121 LGSTVQSETKGIWMWCVPHPTKPTHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSM 185

Human   132 GTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITE 196
            .|||.|||||||:|||||:||||||.||.|:|:||||||.|||||||.||||.|||||:|.||||
Mouse   186 STINQQALEQLHFVTELTQLIRAKSSPREDKVKDSSEFVGFFPDFIWAVRDFALELKLNGRPITE 250

Human   197 DEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQLDSNF 261
            |||||||||||.|.|.::|.||..||.||:|||.:||||||||.:||:|||.:|.|.|:||:.||
Mouse   251 DEYLENALKLIQGDNLKVQQSNMTRECIRYFFPVRKCFVFDRPTSDKRLLLQIENVPENQLERNF 315

Human   262 QMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMAVLAQCENSAA 326
            |::||.|||||||:.||||||.|::|||||||.||:||::|||||..||||||:..|||.|||.|
Mouse   316 QVESEKFCSYIFTNGKTKTLRGGVIVTGNRLGTLVQTYVNAINSGTVPCLENAVTTLAQRENSIA 380

Human   327 VQRAANHYSQQMAQQVRFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKK 391
            ||:||:|||:||||::|.|||||||||.|||.||:||||||||:||||..||||||||.|:|::|
Mouse   381 VQKAADHYSEQMAQRMRLPTDTLQELLTVHAACEKEAIAVFMEHSFKDDEQEFQKKLVVTIEERK 445

Human   392 EDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKA 456
            |:|:.|||.||.::|||||:||||.|.:|||.|.|.|||||::||||:||||..|..|.||||||
Mouse   446 EEFIRQNEAASIRHCQAELERLSESLRKSISCGAFSVPGGHSLYLEARKKIELGYQQVLRKGVKA 510

Human   457 DEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQER 521
            .|||:||||||.::|:||||||||||.||:||||::.|||.||||.|||||:||||:|:||||||
Mouse   511 KEVLKSFLQSQAIMEDSILQSDKALTDGERAIAAERTKKEVAEKELELLRQRQKEQEQVMEAQER 575

Human   522 SFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAE 586
            ||:||||:|::|||.|:|..:||..|||.||:||.||||.|||:|..:.|..||:.|:|::|..
Mouse   576 SFRENIAKLQEKMESEKEMLLREQEKMLEHKLKVQEELLIEGFREKSDMLKNEISHLREEMERT- 639

Human   587 NEEPSVFSQILDVAGSIFIAALPGAAKLVDLGMKILSSL 625
            ..:||:|.||||..|:.||..||||.||..:|:|.|.||
Mouse   640 RRKPSLFGQILDTIGNAFIMILPGAGKLFGVGLKFLGSL 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP7	NP_997281.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..310		228/307 (74%)
		GBP	18..281	CDD:460516	199/262 (76%)
		GBP_C	283..579	CDD:460721	203/295 (69%)
		Interaction with the CYBA-CYBB complex. /evidence=ECO:0000250|UniProtKB:Q91Z40	311..638		208/315 (66%)
		C-terminal tail, required for its localization to cytoplasmic vesicle. /evidence=ECO:0000250|UniProtKB:Q91Z40	590..638		21/36 (58%)
Gbp3	XP_006501782.1	GBP	72..335	CDD:460516	199/262 (76%)
		GBP_C	337..633	CDD:460721	203/295 (69%)