Protein Alignment GBP7 and gbp1

DIOPT Version :9

• Sequence 1: NP_997281.2
• Gene: GBP7 / 388646
• HGNCID: 29606
• Length: 638
• Species: Homo sapiens
• Sequence 2: NP_001016773.1
• Gene: gbp1 / 549527
• XenbaseID: XB-GENE-6045650
• Length: 595
• Species: Xenopus tropicalis
• Alignment Length: 589
• Identity: 289/589 - (49%)
• Similarity: 408/589 - (69%)
• Gaps: 5/589 - (0%)

Human     1 MASEIHMPGPVCLTEN-TKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKG 64
            |:::|||..|:||.|| .....|:|:||.:|||.||.|||||||||.||||||||||||||:..|
 Frog     1 MSAQIHMKDPICLIENRNSNEFVINTEAEQILSQITDPVVVVAIVGKYRTGKSYLMNKLAGRKTG 65

Human    65 FPLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYN 129
            ||||.|::|:||||||||||||.:|:|||:|||||||||:||.|.|:|.|||:|||||||:.|||
 Frog    66 FPLGSTIQSKTKGIWMWCVPHPCQPSHTLVLLDTEGLGDVEKGDSKNDGWIFSLAVLLSSNLVYN 130

Human   130 SMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPI 194
            |||||::.|:|||.|||||::||:.||.|..:|..:..||...||.|.|.||||:|.|:|||..:
 Frog   131 SMGTIDNHAMEQLQYVTELSKLIKLKSNPEQEEKNEPDEFKRIFPSFTWCVRDFSLILELDGKKV 195

Human   195 TEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLH-VEEVREDQLD 258
            ||||||.|:|||..|.:.|.|:.|.|||.|.|:|...||||||:|.:.:.  || :||::|..|:
 Frog   196 TEDEYLMNSLKLKKGTDKQTQDYNLPRECILHYFHSHKCFVFDQPTSSRN--LHRLEELQEQDLE 258

Human   259 SNFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMAVLAQCEN 323
            .:|..|:..||.:|.|....|||..|::|||..|..|...|::.|.||:.||:|||:..|:..||
 Frog   259 EDFVKQTRKFCDHIHTQGVAKTLPGGLIVTGRMLAHLTSLYIETIMSGSVPCMENAVLALSVMEN 323

Human   324 SAAVQRAANHYSQQMAQQV-RFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTM 387
            :.|||.|...|...|.:.: ||||:||||.|.:|...|:||:.||::.||.|::|:|||:..:.:
 Frog   324 TGAVQDALAKYETCMKEHLPRFPTETLQEFLHLHQRSEKEALEVFLKRSFNDENQDFQKEFKNLL 388

Human   388 EKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRK 452
            :.|.::|..:||..|.:.|:..::.|||.|.|.||:|.|..|||||::|.||..|.::|...|||
 Frog   389 DNKMKNFSERNERESTERCEIIIQELSEYLEERISQGEFLKPGGHNLFLVAKMTIMEEYNTTPRK 453

Human   453 GVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMME 517
            |:|:.||||.|:.::..||.:|||:|.:|||.||.||..||:...||:::::|.:.:|..|:.||
 Frog   454 GLKSLEVLQEFISNKKGIEAAILQADVSLTAKEKEIAESQAETAEAERQRQILEENKKYLQESME 518

Human   518 AQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQI 582
            .|::||:::...|.:||:.:|:..:.|..::::.|::....:||.||:....:|..||:.|..:.
 Frog   519 NQKKSFEQHEKMLIEKMDADRQKLIAENERVIAQKLQEQNAMLTAGFQGRVNALQSEIDELYRRN 583

Human   583 EAAE 586
            .|::
 Frog   584 RASK 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP7	NP_997281.2	GTPase domain (Globular). /evidence=ECO:0000250	1..310		178/310 (57%)
		GBP	18..281	CDD:280433	157/263 (60%)
		GBP_C	283..579	CDD:202427	119/296 (40%)
		GBP_C	289..579	CDD:293879	116/290 (40%)
		coiled coil	548..559	CDD:293879	1/10 (10%)
		coiled coil	568..579	CDD:293879	3/10 (30%)
gbp1	NP_001016773.1	P-loop_NTPase	20..281	CDD:304359	157/262 (60%)
		GBP_C	283..579	CDD:202427	119/295 (40%)
		GBP_C	289..579	CDD:293879	116/289 (40%)
		coiled coil	549..560	CDD:293879	1/10 (10%)
		coiled coil	569..579	CDD:293879	3/9 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	345	1.000	Domainoid score	I7575
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	596	1.000	Inparanoid score	I6507
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	1	1.000	-	-		otm54712
Panther	1	1.100	-	-	O	PTHR10751
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160