Protein Alignment GBP7 and gbp1

DIOPT Version :9

• Sequence 1: NP_997281.2
• Gene: GBP7 / 388646
• HGNCID: 29606
• Length: 638
• Species: Homo sapiens
• Sequence 2: NP_001002343.1
• Gene: gbp1 / 436615
• ZFINID: ZDB-GENE-040718-32
• Length: 621
• Species: Danio rerio
• Alignment Length: 633
• Identity: 266/633 - (42%)
• Similarity: 385/633 - (60%)
• Gaps: 31/633 - (4%)

Human     1 MASEIHMPGPVCLTENTKGHLVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGF 65
            |:....||.|:||.||..|.|.:..:|::.||.|.:|||||::|||||||||||||:|||:..||
Zfish     1 MSKPTMMPSPICLVENVNGSLSICKDAIDFLSNINEPVVVVSVVGLYRTGKSYLMNRLAGQQTGF 65

Human    66 PLGCTVKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNS 130
            .||.|::|:||||||||||||.|..|||:|||||||||::|.|.|:|.|||.|||||||:.||||
Zfish    66 ALGNTIESKTKGIWMWCVPHPKKQGHTLVLLDTEGLGDVDKGDSKNDGWIFCLAVLLSSTLVYNS 130

Human   131 MGTINHQALEQLHYVTELTELIRAKSCPRPDEV-EDSSEFVSFFPDFIWTVRDFTLELKLDGHPI 194
            .|||::.|||:|||:|||||.|:.::....||. |:.|:||.|||.|.|.||||||:|.:||..:
Zfish   131 RGTIDNSALEKLHYITELTEQIKIRTAEAADEEDEEDSKFVLFFPSFTWVVRDFTLDLVIDGKNV 195

Human   195 TEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQLDS 259
            .||:||:.||:|..|.|.:....|.||:.||::||.:|||||..|.:.:| :..:|.::|..|..
Zfish   196 NEDQYLDFALQLRKGNNKKALEYNLPRQCIRNYFPSRKCFVFPSPASPEK-MKQLESLQEKDLVP 259

Human   260 NFQMQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMAVLAQCENS 324
            :|...:..||.:||.::..|||:.|..|||..||.|.:.|:|.|:||..|||:||:..||..||.
Zfish   260 DFLEVTGRFCEHIFRNSVVKTLKGGHKVTGKLLGHLAKIYVDTISSGKVPCLDNAVVALANLENK 324

Human   325 AAVQRAANHYSQQMAQQVR--FPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTM 387
            .||:.|...|.:.| ::|:  ||.: :.|:...|......|.|.||:.||||:.||:..:|.:.:
Zfish   325 CAVEEAFKVYERGM-EEVKKTFPVN-VDEISSEHQRFSSLANAEFMKRSFKDEKQEYINQLKEKI 387

Human   388 EKKKEDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRK 452
            :......:..|..||.|.|:..||.|...:.:.:..|.:..|||:.:|.:.:..|.:.|...|.|
Zfish   388 DVYYGCLLEDNGLASKKKCEDLLKDLFSEMNKKLQDGVYSQPGGYELYCKDRDVIVEKYRREPNK 452

Human   453 GVKADEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMME 517
            ||.|:.||..||..:.....|||.:|..||..:|.|..::.:....:::.|..::|:.|.::||.
Zfish   453 GVLAEAVLHEFLNERGAEANSILYTDTKLTENDKKIQEEKERNALMQQKCEEEQEKRIESERMMA 517

Human   518 AQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQI 582
            |::....:.|.|:::|.|:|||...:|..|.:..|:|..||:|.:||||..:.|:||||.||::.
Zfish   518 AEKVRQDDQIKQMQEKFEKEREQMQQETEKAIDSKLKEQEEMLNKGFKERADLLSEEINDLKKEK 582

Human   583 EAAENEEPSVFSQILDVAGSIFIAALPGAA----------KLVDLGMK 620
            :....|               :|..:.|||          :::..|||
Zfish   583 KGFMEE---------------YIMPIVGAAAQILPTILDYRVMMKGMK 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP7	NP_997281.2	GTPase domain (Globular). /evidence=ECO:0000250	1..310		165/309 (53%)
		GBP	18..281	CDD:280433	143/263 (54%)
		GBP_C	283..579	CDD:202427	103/297 (35%)
		GBP_C	289..579	CDD:293879	100/291 (34%)
		coiled coil	548..559	CDD:293879	3/10 (30%)
		coiled coil	568..579	CDD:293879	5/10 (50%)
gbp1	NP_001002343.1	P-loop_NTPase	18..281	CDD:328724	143/263 (54%)
		GBP_C	283..579	CDD:308475	103/297 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I6643
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55037
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100467
Panther	1	1.100	-	-	O	PTHR10751
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.790