DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP7 and atl

DIOPT Version :9

Sequence 1:	NP_997281.2	Gene:	GBP7 / 388646	HGNCID:	29606	Length:	638	Species:	Homo sapiens
Sequence 2:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	99/443 - (22%)
Similarity:	179/443 - (40%)	Gaps:	86/443 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     2 ASEIHMPGPVCLTENTKGHLVVNSEAL-EIL---SAITQPVVVVAIVGLYRTGKSYLM------- 55
            |||.|.             .|:|.:|| |:|   ....:.|.||::.|.:|.|||:|:
  Fly    11 ASEEHT-------------FVLNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYM 62

Human    56 ----------NKLAGKN---KGFPLGCTVKSETKGIWMW----CVPHPSKPNHTLILLDTEGLGD 103
                      :.|.|::   :||......:.:|.||.||    ...:|:.....:|||||:|..|
  Fly    63 YSKYVHHDATDWLGGESDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFD 127

Human   104 MEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQALEQLHYVTELTELIRAKSCPRPDEVEDSSE 168
             .:|..:..:.:|||:.:|||..:||....|....|:.|...||...|..|.:..:|
  Fly   128 -SQSTVRDCATVFALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKP-------- 183

Human   169 FVSFFPDFIWTVRDFTLELKLDGHPITEDEYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKC 233
                |....:.|||::...:.:...:..|:.|:..|::...::|::|:.   |..|...|.:..|
  Fly   184 ----FQRLQFLVRDWSFPYEAEYGALGGDKILKRRLEVSDKQHPELQSL---RRHISSCFTEVAC 241

Human   234 FVFDRPINDKKLLLHVEEVREDQLDSNFQMQSENFCSYIFTHAKTKTLREGIL---VTGNR---- 291
            |:...|        .:......:.|...|..:..|.|.:.:........:.::   ::|.|
  Fly   242 FLMPHP--------GLNVATNPKFDGRLQDITPEFKSSLRSLVPMLLAPDNLVYKEISGQRVRAR 298

Human   292 -LGMLVETYLDAINSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELLDV 355
             |....::|::.......|..::.:...|:..:..||..|...|.|.|.:..   ..|...|...
  Fly   299 DLIQYFQSYMNIYKGNELPEPKSMLVATAEANHLTAVAAAKELYGQLMEEVC---GGTRPYLSTA 360

Human   356 HAVCEREAI---AVFMEYSFKDK------SQEFQKKLVDTMEKKKEDFVLQNE 399
            |...|...:   |:| :::.|.|      :::|:|:|.|.:|:...::...||
  Fly   361 HLQTEHLRVKDKALF-QFAAKRKMGGEEFTEKFRKQLEDDLEEVFTNYQAHNE 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP7	NP_997281.2	GTPase domain (Globular). /evidence=ECO:0000250	1..310		76/343 (22%)
		GBP	18..281	CDD:280433	68/290 (23%)
		GBP_C	283..579	CDD:202427	27/134 (20%)
		GBP_C	289..579	CDD:293879	27/125 (22%)
		coiled coil	548..559	CDD:293879
		coiled coil	568..579	CDD:293879
atl	NP_001287506.1	GBP	14..289	CDD:280433	69/311 (22%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	23/101 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142064
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750