Protein Alignment GBP7 and SPAC222.14c

DIOPT Version :9

• Sequence 1: NP_997281.2
• Gene: GBP7 / 388646
• HGNCID: 29606
• Length: 638
• Species: Homo sapiens
• Sequence 2: NP_593153.1
• Gene: SPAC222.14c / 2541926
• PomBaseID: SPAC222.14c
• Length: 762
• Species: Schizosaccharomyces pombe
• Alignment Length: 679
• Identity: 139/679 - (20%)
• Similarity: 238/679 - (35%)
• Gaps: 214/679 - (31%)

Human    40 VVAIVGLYRTGKSYLMNKLAGKNKGFPLGCTVKSETKGIWMWCVPHPSKPNHT-LILLDTEGLGD 103
            |||::|...||||.|:|.|.|.:.........:..|||||:      ||.|:: ::::|.||...
pombe    41 VVAVLGSQSTGKSTLLNNLFGTSFSVMDASKRQQTTKGIWL------SKANNSPILVMDVEGTDG 99

Human   104 MEKSDPKSDSWIFALAVLLSSSFVY-----NSMGTINHQALEQLHYVTELT-ELIRAK------- 155
            .|:.:.:......||..:.:|..:.     |.:|......:..|..|.|:. :|...|
pombe   100 RERGEDQDFERKSALFSISTSEVIIVNMWENQVGLYQGSNMALLKTVLEVNLQLFHNKKERCLLQ 164

Human   156 ----------------------------SCPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGH 192
                                        |..:|:..|:|            .:.|| .::...|.
pombe   165 FVIRDFLGNTSMENLADTIMTDLNNIWASLSKPEGFENS------------VINDF-FDVGFTGL 216

Human   193 P---ITEDEYLENALKLISGKNPQIQNSNKPREWIRHF-----FPKQKCFVFDRPINDKKLLLHV 249
            |   :..|.:.|....|   :...:.|:|.  ::|.:.     .|.....::.|.|.|.     :
pombe   217 PHKILCSDAFSEAVDSL---RERFVDNNNS--DYIFNVSYHKKIPADGFSLYTREIWDT-----I 271

Human   250 EEVREDQLDSNFQMQSENFCSYIFTH-----AKTKTLREGILVTGN-------RLGMLVETYLDA 302
            |..::..|.:..|:.::..|..|.|.     :...|:.:...:.||       :|..:.||.::|
pombe   272 ENNKDLDLPTQQQLLAQYRCDEIITEVMEPFSTACTILQKEFLPGNLCKDLPTKLLNMFETVIEA 336

Human   303 INSGATPCLENAMAVLAQCENSAAVQRAANHYSQQMAQQVRFPTDTLQELL---DVHA------- 357
            .:                        |.|:.|:..:.|:.:      |||:   |.|.
pombe   337 YD------------------------RQASRYNVHIYQKKK------QELIASVDSHLYVFFQAQ 371

Human   358 --VCEREAIAVFMEYS--------FKDKSQEFQKKLVDTMEKKKED------------FVLQNEE 400
              ...:|.|..|.:.|        ||:.|.....:||:.|.::.|.            |:|:..|
pombe   372 LNALHKELIKSFFDASNEFPSDTPFKESSSIKINELVNKMREEGESLSLPHVHWDVDPFILKLSE 436

Human   401 A----SAKYCQAELK-RLSELLT-------ESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKG 453
            .    |...|:.:|| :|.||.|       |::.  ..|....||::
pombe   437 ELTQNSETLCKEKLKEKLEELFTGFEFEVSEAVE--VAFQKLSHNVW------------------ 481

Human   454 VKADEVLQSFLQSQVVIEESI-------LQSDKALTAGEKAIAAKQ------AKKEAAEKEQELL 505
               |.:|..||.:|....|.|       :..|...|..|..|..|:      .||..:|..:.||
pombe   482 ---DTLLNEFLAAQNTTIEKIKNIVPFYVDIDDTKTTEEYIINFKKNSWLFFRKKIDSEMSEVLL 543

Human   506 RQKQKEQQQMMEAQERSFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEEL-LTEGFKEIFE 569
            :|:.:   ...|...|...:.:.:|.||......:|...|.|.|. .:.||..: :::|   .:.
pombe   544 QQRLR---VYFEELFRYDSDGMPKLWKKSGTIDRDYRESLTKTLD-LINVLASIKVSDG---NYP 601

Human   570 SLNEEINRLKEQIEAAENEEPSVFSQILD 598
            .||.:|..|:     .|...|:.|..||:
pombe   602 DLNVDIKTLE-----PEYTSPASFFTILN 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP7	NP_997281.2	GTPase domain (Globular). /evidence=ECO:0000250	1..310		65/331 (20%)
		GBP	18..281	CDD:280433	58/295 (20%)
		GBP_C	283..579	CDD:202427	74/360 (21%)
		GBP_C	289..579	CDD:293879	74/354 (21%)
		coiled coil	548..559	CDD:293879	3/10 (30%)
		coiled coil	568..579	CDD:293879	3/10 (30%)
SPAC222.14c	NP_593153.1	P-loop_NTPase	45..752	CDD:304359	136/675 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910