DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GBP7 and mto1

DIOPT Version :9

Sequence 1:NP_997281.2 Gene:GBP7 / 388646 HGNCID:29606 Length:638 Species:Homo sapiens
Sequence 2:NP_588284.1 Gene:mto1 / 2539467 PomBaseID:SPCC417.07c Length:1115 Species:Schizosaccharomyces pombe


Alignment Length:604 Identity:122/604 - (20%)
Similarity:214/604 - (35%) Gaps:183/604 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    87 SKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTINHQAL-----EQLHYVT 146
            |:|..:|.|.:...:.|..:.:      :|.|.  |...|:|:.:...:.|.:     :.:...|
pombe   243 SQPGSSLTLKEQANVIDNLRKE------VFGLK--LKCYFLYDQLNKFHDQEVQDIMKQNIDLKT 299

Human   147 ELTELIRA-----------KSCPRPDE--------------VEDSSEFVSFFPDFIWTVRDFTLE 186
            ...||.||           :|..:||:              :...|.:.....:...|.|.|.  
pombe   300 LTMELQRAVAGYEKKISGLESRIKPDQSFNLSTPSPAPSNLITLQSRYSQALSELETTKRAFA-- 362

Human   187 LKLDGHPITEDEYLENALKLISGK--NPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHV 249
                            ||:....|  |..:...|:.|..:.:        :.|....:|:.||..
pombe   363 ----------------ALRKEKSKKTNYSVGAYNEDRNVLSN--------MLDNERREKEALLQE 403

Human   250 EEVREDQLDSNFQMQSENFCSYIF-THAKTKTL--------REGILV---TGNRLGMLVETYLDA 302
            .|....||.....|.::|....:. |..::..|        .|.:|:   ..:||...||....|
pombe   404 LESLRVQLSKKVPMPAKNTDERVIETLQRSNELLRMDISMQNEALLLRKQENDRLVKQVEELTVA 468

Human   303 INSGATPCLENAMAVLAQCENSAAVQRAANH---------YSQ-------------QMAQQVRFP 345
            :|||....:..|.:...:..:|..|.|....         |.|             :|.||.|..
pombe   469 LNSGKMNAIVEAESSKNELWDSMMVSRMKTQEQSIELTRLYKQLQDIEEDYENKLMRMEQQWRED 533

Human   346 TDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQ--KKLVDTMEKKKEDFVLQNEEASAKY--- 405
            .|.|||.::                   :.:||.|  |:::....|:.:|:    ||...|.   
pombe   534 VDQLQEYVE-------------------EITQELQDTKEVLSKSSKESDDY----EEVVGKLRTE 575

Human   406 CQAELKRLSELL---TESISRGTFFVPGGHNIYLEAKKKIEQDYT-LVPRKGVKADEV--LQSFL 464
            .:.|:::..:.:   .||||           ::.|..:|:..:.| |..|...|..|.  ||..|
pombe   576 AEREIEKFEKTIRENEESIS-----------LFKEEVEKLTDEITQLSERYNDKCHEFDELQKRL 629

Human   465 QSQVVIEESILQSDKA----------------LTAGEKAIAAK---QAKKEAAEKEQELLRQKQK 510
            |:   :||   :::||                :|..|.....|   :.|:..|.||.||:  |..
pombe   630 QT---LEE---ENNKAKEDSTSKTSNLLEQLKMTEAEVDSLRKENEENKQVIALKESELV--KSN 686

Human   511 EQQQMMEAQERSFQENIAQLKKKME------RERENYMRELRKMLSHKMKVLEELLTEGFKEIFE 569
            :.:.::..|..|..:.::|||.:||      ....:|:..|::..:.::..|.:.|.|     ||
pombe   687 DNKLLLNEQIESLNDQLSQLKTEMESVTTSKESLADYLSNLKERHNDELDSLNKKLRE-----FE 746

Human   570 SLNEEINRLKEQIEAAENE 588
            .:....:.||.:||...|:
pombe   747 GILSSNSSLKSEIEERNNQ 765

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GBP7NP_997281.2 GTPase domain (Globular). /evidence=ECO:0000250 1..310 50/266 (19%)
GBP 18..281 CDD:280433 39/226 (17%)
GBP_C 283..579 CDD:202427 77/356 (22%)
GBP_C 289..579 CDD:293879 75/347 (22%)
coiled coil 548..559 CDD:293879 1/10 (10%)
coiled coil 568..579 CDD:293879 2/10 (20%)
mto1NP_588284.1 Cnn_1N 252..319 CDD:285263 12/74 (16%)
Fib_alpha 511..611 CDD:285864 26/133 (20%)
Mto2_bdg 1052..1101 CDD:289572
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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