Protein Alignment GBP7 and gbp5

DIOPT Version :10

• Sequence 1: NP_997281.2
• Gene: GBP7 / 388646
• HGNCID: 29606
• Length: 638
• Species: Homo sapiens
• Sequence 2: NP_001120244.2
• Gene: gbp5 / 100145295
• XenbaseID: XB-GENE-5756296
• Length: 636
• Species: Xenopus tropicalis
• Alignment Length: 634
• Identity: 312/634 - (49%)
• Similarity: 426/634 - (67%)
• Gaps: 15/634 - (2%)

Human     7 MPGPVCLTENTKGH-LVVNSEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFPLGCT 70
            |..|:||..|.:|. |:||.|||:||..||||||||||||.||||||||||||||...||.||.|
 Frog     6 MEEPMCLIGNKEGEDLIVNQEALQILLKITQPVVVVAIVGKYRTGKSYLMNKLAGARNGFALGST 70

Human    71 VKSETKGIWMWCVPHPSKPNHTLILLDTEGLGDMEKSDPKSDSWIFALAVLLSSSFVYNSMGTIN 135
            |:|:||||||||||||:|..:||:|||||||||:||.|.|:|:|||:||:||||:.||||||||:
 Frog    71 VQSKTKGIWMWCVPHPTKQGNTLVLLDTEGLGDVEKGDSKNDAWIFSLAILLSSTLVYNSMGTID 135

Human   136 HQALEQLHYVTELTELIRAKS---CPRPDEVEDSSEFVSFFPDFIWTVRDFTLELKLDGHPITED 197
            .||::.|||||||||||:.||   ....:|.::|.||..|||.|||.||||||:|:.:|.|||||
 Frog   136 QQAMDNLHYVTELTELIKVKSDEAQATEEEDDESGEFKRFFPSFIWCVRDFTLKLEKNGSPITED 200

Human   198 EYLENALKLISGKNPQIQNSNKPREWIRHFFPKQKCFVFDRPINDKKLLLHVEEVREDQLDSNFQ 262
            :||.:||:|..|...::|:.|.||:.|||:|...||||||||.: ...|..:||::|.:|:|.|.
 Frog   201 QYLLDALELKKGVGKKVQDYNLPRQCIRHYFHSHKCFVFDRPAS-TLALQRLEELQESELESKFV 264

Human   263 MQSENFCSYIFTHAKTKTLREGILVTGNRLGMLVETYLDAINSGATPCLENAMAVLAQCENSAAV 327
            .::..|||.|:..:..|||..|..|||..||.|..:|.:||.||:.||:|||:..|||.|||.||
 Frog   265 EKAAEFCSCIYGKSNAKTLVGGYTVTGRLLGNLAVSYTEAIRSGSIPCMENAVIALAQIENSRAV 329

Human   328 QRAANHYSQQMAQQV-RFPTDTLQELLDVHAVCEREAIAVFMEYSFKDKSQEFQKKLVDTMEKKK 391
            |.|...|.::|::|: :|||:|.:|.|.:|..||:||..|||..||||::.|:||:|:|.:.:||
 Frog   330 QEALTKYEEEMSKQIAKFPTETQEEFLSIHQECEKEATQVFMGLSFKDENLEYQKQLIDELAEKK 394

Human   392 EDFVLQNEEASAKYCQAELKRLSELLTESISRGTFFVPGGHNIYLEAKKKIEQDYTLVPRKGVKA 456
            ..:.|.|||.|||.|:|.|::|||.|...|..|.|..|||:..::..|..:..:|.....|||||
 Frog   395 SKYSLYNEEESAKKCKAILQKLSENLEREILNGKFSKPGGYTQFISEKNLLVDEYNRTKGKGVKA 459

Human   457 DEVLQSFLQSQVVIEESILQSDKALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQER 521
            .|:||.||..:..:|.:|||:|::||..||.||.::|:.|.||:|::::.:..:..::.:|||::
 Frog   460 LEILQEFLNEKENVEAAILQADQSLTHKEKEIAEQRARTETAEREKQIVEENNRRLEKDIEAQKK 524

Human   522 SFQENIAQLKKKMERERENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAE 586
            |.:|:...:::|||.||:..|.:...|:..|:|..||:||:||.:..|.|..:|..:|.:..||
 Frog   525 SLEEHKKMMEEKMEEERKKLMEQNEWMIKEKLKEQEEMLTKGFHKESEMLKNQIEDIKRKNSAA- 588

Human   587 NEEPSVFSQILDVAGSIFIAALPGAAKLVDLGMKILSSLCNRL-RNPGK 634
             .|.|:...||.|   ||   ||......:||..:...|...| |..||
 Frog   589 -AERSLLGDILSV---IF---LPIGLAARELGKGLERGLGRGLERGLGK 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP7	NP_997281.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..310		179/306 (58%)
		GBP	18..281	CDD:460516	160/266 (60%)
		GBP_C	283..579	CDD:460721	126/296 (43%)
		Interaction with the CYBA-CYBB complex. /evidence=ECO:0000250|UniProtKB:Q91Z40	311..638		131/326 (40%)
		C-terminal tail, required for its localization to cytoplasmic vesicle. /evidence=ECO:0000250|UniProtKB:Q91Z40	590..638		15/46 (33%)
gbp5	NP_001120244.2	GBP	19..283	CDD:460516	159/264 (60%)
		GBP_C	285..582	CDD:460721	126/296 (43%)