DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcad and Acad8

DIOPT Version :9

Sequence 1:	NP_648149.1	Gene:	Mcad / 38864	FlyBaseID:	FBgn0035811	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_080138.2	Gene:	Acad8 / 66948	MGIID:	1914198	Length:	413	Species:	Mus musculus

Alignment Length:	404	Identity:	136/404 - (33%)
Similarity:	226/404 - (55%)	Gaps:	9/404 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ALRQLVSQSRAYAAVSHVSPNGTSFALTEDQLQLQELARKFTREEIIPVAAQYDKSGEYPWPIIK 75
            ||:.| :|:...:....:.|   |..|.|:|...|::|..|...|:.|..|::|:...:|..:::
Mouse    17 ALKSL-AQTHHRSITFCIDP---SLGLNEEQKGFQKVAFDFAAREMAPNMAEWDQKELFPVDVMR 77

  Fly    76 KAWELGLMNNHIPADIGGLDLDVFTTCLSAEELAYGCTGIMTALEASGLGQTPVILSGNKEQKKK 140
            ||.:||....::..|:||..|....|.:..|.||.|||.....:....:....:...||:||:.|
Mouse    78 KAAQLGFGGVYVRTDVGGSGLSRLDTSVIFEALATGCTSTTAYISIHNMCAWMIDSFGNEEQRHK 142

  Fly   141 YLGRLLEEPLVAAYCVTEPGAGSDVSGIKTRAEKKGDEWVINGQKMWITNGGVANWYFVLARTNP 205
            :...|......|:||:||||:|||.:.:.|.|:::||.:::||.|.:|:.||.::.|.|:.||..
Mouse   143 FCPPLCTMEKFASYCLTEPGSGSDAASLLTSAKQQGDHYILNGSKAFISGGGESDIYVVMCRTGE 207

  Fly   206 DPKCPPSKAFTGFIVERDSPGLTPGRKELNMGQRASDTRGITFEDVRVPKENVLIGEGAGFKIAM 270
            .    .:|..:..:||:.:|||:.|:||..:|..:..||.:.|||..||..|.:..||.||.|||
Mouse   208 S----GAKGISCIVVEKGTPGLSFGKKEKKVGWNSQPTRAVIFEDCAVPVANRIGTEGQGFLIAM 268

  Fly   271 GTFDKTRPPVAAGAVGLAQRCLDEALKYALERKTFGVPIAYHQAVQFMLADMAIGVETSRLAWRL 335
            ...:..|..||:.::|.|...:....::...||.||.|:|..|.:||.|||||..:..|||..|.
Mouse   269 KGLNGGRINVASCSLGAAHASVILTQEHLKVRKQFGAPLARSQYLQFQLADMATKLVASRLMIRT 333

  Fly   336 SAWEIDQGRRNSY-YASIAKCHAADMANKIASDAVQIFGGNGFNSEYPVEKLMRDAKIYQIYEGT 399
            :|..:.:.|.::. ..|:||..|.:....|.:.|:|:.||.|:..:|.|::.|||::::||.||:
Mouse   334 AAVALQEEREDAVALCSMAKLFATEECFAICNQALQMHGGYGYLKDYAVQQYMRDSRVHQILEGS 398

  Fly   400 SQIQRLIISRNMYE 413
            :::.|::||||:.:
Mouse   399 NEVMRMLISRNLLQ 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcad	NP_648149.1	CaiA	35..411	CDD:224871	129/376 (34%)
Mcad	NP_648149.1	MCAD	37..414	CDD:173846	130/378 (34%)
Acad8	NP_080138.2	CaiA	37..411	CDD:224871	130/377 (34%)
		IBD	39..412	CDD:173851	130/376 (35%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9UKU7	272..275		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281661at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920