Protein Alignment Mcad and ACOX1

DIOPT Version :10

• Sequence 1: NP_648149.1
• Gene: Mcad / 38864
• FlyBaseID: FBgn0035811
• Length: 419
• Species: Drosophila melanogaster
• Sequence 2: NP_004026.2
• Gene: ACOX1 / 51
• HGNCID: 119
• Length: 660
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 104/479 - (21%)
• Similarity: 170/479 - (35%)
• Gaps: 158/479 - (32%)

  Fly    25 VSHV---SPNGT-------SFALTEDQLQLQELARKFTREEIIPVAAQYDKSGEYPWPIIKKAWE 79
            ::|:   ||..|       :..|.:...|.::| ...||.:...||.:  ||.    .::||..|
Human    19 LTHILDGSPEKTRRRREIENMILNDPDFQHEDL-NFLTRSQRYEVAVR--KSA----IMVKKMRE 76

  Fly    80 LGL--------MNNHI------PADIGGLDLDVFTTCLSAEELAYGCTGIMTALEASGLGQTPVI 130
            .|:        ..|.:      |.|   |.|.:|...|..:..|
Human    77 FGIADPDEIMWFKNFVHRGRPEPLD---LHLGMFLPTLLHQATA--------------------- 117

  Fly   131 LSGNKEQKKKYLGRLLEEPLVAAYCVTEPGAGSDVSGIKTRA--EKKGDEWVINGQ-----KMWI 188
                 ||::::........::..|..||.|.|:.:.|::|.|  :.:..|:::|..     |.|
Human   118 -----EQQERFFMPAWNLEIIGTYAQTEMGHGTHLRGLETTATYDPETQEFILNSPTVTSIKWW- 176

  Fly   189 TNGGV---ANWYFVLARTNPDPKCPPSKAFTGFIVE----RDSPGLTPGRKELNMGQRASDTRGI 246
             .||:   :|...|||:.....||....||...|.|    :..||:|.|......|....|...:
Human   177 -PGGLGKTSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDEIDNGYL 240

  Fly   247 TFEDVRVPKENVLIGEGAGFKIAM----GTFDK---------TRPPVAAGAVGLAQRCLDE---- 294
            ..::.|:|:||:|:      |.|.    ||:.|         |...|.:..||.|.|.|.:
Human   241 KMDNHRIPRENMLM------KYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTI 299

  Fly   295 ALKYALER----------------------KTFGVPIAYHQAVQFMLADMAIGVETSRLAWRLSA 337
            |::|:..|                      |.|.: :|...|.||:.|.|.   ||..
Human   300 AIRYSAVRHQSEIKPGEPEPQILDFQTQQYKLFPL-LATAYAFQFVGAYMK---ETYH------- 353

  Fly   338 WEIDQGRRNSYYASIAKCHAADMANK-----IASDAVQ----IFGGNGFN--SEYPVEKLMRDAK 391
             .|::|......:.:.:.||.....|     .|:..::    ..||:|::  |..|        .
Human   354 -RINEGIGQGDLSELPELHALTAGLKAFTSWTANTGIEACRMACGGHGYSHCSGLP--------N 409

  Fly   392 IYQ------IYEGTSQIQRLIISR 409
            ||.      .:||.:.:..|..:|
Human   410 IYVNFTPSCTFEGENTVMMLQTAR 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcad	NP_648149.1	MCAD	37..414	CDD:173846	100/457 (22%)
ACOX1	NP_004026.2	AXO	3..637	CDD:173839	104/479 (22%)