DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcad and acadm

DIOPT Version :9

Sequence 1:	NP_648149.1	Gene:	Mcad / 38864	FlyBaseID:	FBgn0035811	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_998175.2	Gene:	acadm / 406283	ZFINID:	ZDB-GENE-040426-1945	Length:	426	Species:	Danio rerio

Alignment Length:	397	Identity:	292/397 - (73%)
Similarity:	338/397 - (85%)	Gaps:	2/397 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SQSRAYAAVSHV--SPNGTSFALTEDQLQLQELARKFTREEIIPVAAQYDKSGEYPWPIIKKAWE 79
            :|:.|.||.:.:  ...|.||.|||.|.:.||:||||.||||:|.|..||:|||||:|:||:|||
Zfish    24 AQASAKAATASLKGGNGGFSFELTEQQKEFQEVARKFAREEIVPAAPSYDRSGEYPFPLIKRAWE 88

  Fly    80 LGLMNNHIPADIGGLDLDVFTTCLSAEELAYGCTGIMTALEASGLGQTPVILSGNKEQKKKYLGR 144
            |||||.|||.|.||:.|.:|..||..|||||||||:.||:||:.|||.|||::||..|:||||||
Zfish    89 LGLMNGHIPEDCGGMGLGIFDACLITEELAYGCTGVQTAIEANSLGQMPVIIAGNDAQRKKYLGR 153

  Fly   145 LLEEPLVAAYCVTEPGAGSDVSGIKTRAEKKGDEWVINGQKMWITNGGVANWYFVLARTNPDPKC 209
            :.||||:.|||||||||||||:||||||.||||::|||||||||||||.|||||:||||:.||||
Zfish   154 MTEEPLMCAYCVTEPGAGSDVAGIKTRAVKKGDDYVINGQKMWITNGGKANWYFLLARTDSDPKC 218

  Fly   210 PPSKAFTGFIVERDSPGLTPGRKELNMGQRASDTRGITFEDVRVPKENVLIGEGAGFKIAMGTFD 274
            |.|||||||||:.|:||:.|||||||||||.|||||||||||.:||||||||||||||||||.||
Zfish   219 PASKAFTGFIVDADTPGVQPGRKELNMGQRCSDTRGITFEDVVIPKENVLIGEGAGFKIAMGAFD 283

  Fly   275 KTRPPVAAGAVGLAQRCLDEALKYALERKTFGVPIAYHQAVQFMLADMAIGVETSRLAWRLSAWE 339
            ||||||||||.|||||.|:||.|||:||||||..||.||||.|:||:||:.||.:|:|::.:|||
Zfish   284 KTRPPVAAGATGLAQRALEEATKYAMERKTFGKFIAEHQAVSFLLAEMAMKVELARMAYQRAAWE 348

  Fly   340 IDQGRRNSYYASIAKCHAADMANKIASDAVQIFGGNGFNSEYPVEKLMRDAKIYQIYEGTSQIQR 404
            :|.||||:|||||||..|.|:||:.|||||||||||||||||||||||||||||||||||:||||
Zfish   349 VDMGRRNTYYASIAKAFAGDIANQCASDAVQIFGGNGFNSEYPVEKLMRDAKIYQIYEGTAQIQR 413

  Fly   405 LIISRNM 411
            |||||.:
Zfish   414 LIISREV 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcad	NP_648149.1	CaiA	35..411	CDD:224871	286/375 (76%)
Mcad	NP_648149.1	MCAD	37..414	CDD:173846	285/375 (76%)
acadm	NP_998175.2	CaiA	44..426	CDD:224871	286/377 (76%)
acadm	NP_998175.2	MCAD	46..423	CDD:173846	285/375 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	235	1.000	Domainoid score	I2305
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3
Inparanoid	1	1.050	601	1.000	Inparanoid score	I918
OMA	1	1.010	-	-		QHG56625
OrthoDB	1	1.010	-	-		D281661at33208
OrthoFinder	1	1.000	-	-		FOG0005377
OrthoInspector	1	1.000	-	-		oto41016
orthoMCL	1	0.900	-	-		OOG6_101120
Panther	1	1.100	-	-	LDO	PTHR48083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3931
SonicParanoid	1	1.000	-	-		X3813
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.870