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Protein Alignment Mcad and GCDH

DIOPT Version :9

Sequence 1:	NP_648149.1	Gene:	Mcad / 38864	FlyBaseID:	FBgn0035811	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_000150.1	Gene:	GCDH / 2639	HGNCID:	4189	Length:	438	Species:	Homo sapiens

Alignment Length:	392	Identity:	121/392 - (30%)
Similarity:	187/392 - (47%)	Gaps:	44/392 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LTEDQLQLQELARKFTREEIIPVAAQYDKSGEYPWPIIKKAWELGLMNNHIPADIGGLDLDVFTT 101
            ||.|::.:::..|.:.:|.::|.....:::..:...||.:..|||::...|..          ..
Human    60 LTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKG----------YG 114

  Fly   102 CLSAEELAYGC---------TGIMTALEA-SGLGQTPVILSGNKEQKKKYLGRLLEEPLVAAYCV 156
            |.....:|||.         :|..:|:.. |.|...|:...|::||::|||.:|.:..|:..:.:
Human   115 CAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGL 179

  Fly   157 TEPGAGSDVSGIKTRA--EKKGDEWVINGQKMWITNGGVANWYFVLARTNPDPKCPPSKAFTGFI 219
            |||.:|||.|.::|||  ......:.:||.|.||||..:|:.:.|.||      |... ...||:
Human   180 TEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWAR------CEDG-CIRGFL 237

  Fly   220 VERDSPGLTPGRKELNMGQRASDTRGITFEDVRVPKENVLIGE---GAGFKIAMGTFDKTRPPVA 281
            :|:...||:..|.:.....|||.|..|..:.|.||:||||.|.   |..|    |..:..|..:|
Human   238 LEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPF----GCLNNARYGIA 298

  Fly   282 AGAVGLAQRCLDEALKYALERKTFGVPIAYHQAVQFMLADM----AIGVETSRLAWRLSAWEIDQ 342
            .|.:|.::.||..|.:|||:|..||||:|.:|.:|..||||    .:|:.......||.    ||
Human   299 WGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLK----DQ 359

  Fly   343 GRRNSYYASIAKCHAADMANKIASDAVQIFGGNGFNSEYPVEKLMRDAKIYQIYEGTSQIQRLII 407
            .:......|:.|.:....|..||..|..:.||||.:.||.|.:...:.:....||||..|..||:
Human   360 DKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALIL 424

  Fly   408 SR 409
            .|
Human   425 GR 426

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.