DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcad and acdh-7

DIOPT Version :9

Sequence 1:	NP_648149.1	Gene:	Mcad / 38864	FlyBaseID:	FBgn0035811	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_510789.1	Gene:	acdh-7 / 181758	WormBaseID:	WBGene00020812	Length:	412	Species:	Caenorhabditis elegans

Alignment Length:	399	Identity:	238/399 - (59%)
Similarity:	297/399 - (74%)	Gaps:	0/399 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RQLVSQSRAYAAVSHVSPNGTSFALTEDQLQLQELARKFTREEIIPVAAQYDKSGEYPWPIIKKA 77
            |.|...:|.::..:.....|..|.||.||.:.:...|||..:|:||||.:|||:.||||.|||||
Worm     4 RNLTKCTRLFSTTNKAMSTGMDFQLTADQAEFRANVRKFVADEVIPVAGEYDKTMEYPWEIIKKA 68

  Fly    78 WELGLMNNHIPADIGGLDLDVFTTCLSAEELAYGCTGIMTALEASGLGQTPVILSGNKEQKKKYL 142
            ...|.:...||...|||.:|:.:.|:.:||:||||:||.||:.|:.|..||:||..|.:.||::|
Worm    69 HAQGYLIADIPEAYGGLGVDMVSNCIISEEMAYGCSGIATAIMANDLALTPLILCANDDIKKRFL 133

  Fly   143 GRLLEEPLVAAYCVTEPGAGSDVSGIKTRAEKKGDEWVINGQKMWITNGGVANWYFVLARTNPDP 207
            ||:::.|.||:|.||||||||||:|:||:.||||||:::||.||||||.|.|||:|||||::|||
Worm   134 GRMIDNPFVASYAVTEPGAGSDVAGVKTKCEKKGDEYILNGSKMWITNAGHANWFFVLARSDPDP 198

  Fly   208 KCPPSKAFTGFIVERDSPGLTPGRKELNMGQRASDTRGITFEDVRVPKENVLIGEGAGFKIAMGT 272
            |....||||.|:||.|:||||.||||:|||||.||||||||||||||..||:...|.|||:||.|
Worm   199 KTAAGKAFTAFVVEGDTPGLTRGRKEINMGQRCSDTRGITFEDVRVPAANVVGAPGEGFKVAMKT 263

  Fly   273 FDKTRPPVAAGAVGLAQRCLDEALKYALERKTFGVPIAYHQAVQFMLADMAIGVETSRLAWRLSA 337
            ||||||.|||.|.|:|.||||.|.:|:||||.||..||.||.|.|:||:|||..|.:||....|.
Worm   264 FDKTRPTVAALATGVAYRCLDVATQYSLERKAFGTQIANHQGVSFLLAEMAINCELARLMTYKSG 328

  Fly   338 WEIDQGRRNSYYASIAKCHAADMANKIASDAVQIFGGNGFNSEYPVEKLMRDAKIYQIYEGTSQI 402
            .|:|.||..||||||||..|:|.||:.|::|||||||.|||:|||.|||||||||:|||||||||
Worm   329 AEVDAGRPGSYYASIAKLFASDTANQAATNAVQIFGGAGFNTEYPAEKLMRDAKIFQIYEGTSQI 393

  Fly   403 QRLIISRNM 411
            ||::|:|.:
Worm   394 QRMVIARQL 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcad	NP_648149.1	CaiA	35..411	CDD:224871	234/375 (62%)
Mcad	NP_648149.1	MCAD	37..414	CDD:173846	233/375 (62%)
acdh-7	NP_510789.1	CaiA	24..408	CDD:224871	234/379 (62%)
acdh-7	NP_510789.1	ACAD	28..405	CDD:299127	233/375 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163595
Domainoid	1	1.000	163	1.000	Domainoid score	I2403
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3
Inparanoid	1	1.050	493	1.000	Inparanoid score	I770
Isobase	1	0.950	-	0	Normalized mean entropy	S2116
OMA	1	1.010	-	-		QHG56625
OrthoDB	1	1.010	-	-		D281661at33208
OrthoFinder	1	1.000	-	-		FOG0005377
OrthoInspector	1	1.000	-	-		otm14066
orthoMCL	1	0.900	-	-		OOG6_101120
Panther	1	1.100	-	-	O	PTHR48083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3931
SonicParanoid	1	1.000	-	-		X3813
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.790