DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mcad and acdh-8

DIOPT Version :9

Sequence 1:	NP_648149.1	Gene:	Mcad / 38864	FlyBaseID:	FBgn0035811	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_495142.1	Gene:	acdh-8 / 173979	WormBaseID:	WBGene00019406	Length:	412	Species:	Caenorhabditis elegans

Alignment Length:	380	Identity:	236/380 - (62%)
Similarity:	288/380 - (75%)	Gaps:	0/380 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SFALTEDQLQLQELARKFTREEIIPVAAQYDKSGEYPWPIIKKAWELGLMNNHIPADIGGLDLDV 98
            ||.|::.|.::|..|.||:::.::|.||::|||||:||.|:|:|..||.||..||...||..|..
Worm    22 SFELSDTQKEIQSHAIKFSKDVLVPNAAKFDKSGEFPWEIVKQAHSLGFMNTIIPEKYGGPGLSN 86

  Fly    99 FTTCLSAEELAYGCTGIMTALEASGLGQTPVILSGNKEQKKKYLGRLLEEPLVAAYCVTEPGAGS 163
            ..|.|..|.|:|||:|:..|:....|...|:.|||.:||||||||.|..||::|:||||||||||
Worm    87 LDTALIVEALSYGCSGLQIAIFGPSLAAAPICLSGTEEQKKKYLGMLAAEPIIASYCVTEPGAGS 151

  Fly   164 DVSGIKTRAEKKGDEWVINGQKMWITNGGVANWYFVLARTNPDPKCPPSKAFTGFIVERDSPGLT 228
            ||:|:||:|.|:|||::|||.|.|||.||.|.|:||||||:.:||.|..||||.|||:.|:||:|
Worm   152 DVNGVKTKAVKQGDEYIINGSKAWITGGGHAKWFFVLARTDDNPKTPAGKAFTAFIVDGDTPGIT 216

  Fly   229 PGRKELNMGQRASDTRGITFEDVRVPKENVLIGEGAGFKIAMGTFDKTRPPVAAGAVGLAQRCLD 293
            .|:||.|||||.||||.||||||||||||:|...|||||:|||.||.|||.|||.|||||.||||
Worm   217 RGKKENNMGQRCSDTRSITFEDVRVPKENILGAPGAGFKVAMGAFDLTRPQVAASAVGLAWRCLD 281

  Fly   294 EALKYALERKTFGVPIAYHQAVQFMLADMAIGVETSRLAWRLSAWEIDQGRRNSYYASIAKCHAA 358
            |:.|||:||..||.|||.||.||||:|||||.:|.|||....:|.|:|....:||.||||||.||
Worm   282 ESTKYAMERHAFGTPIANHQGVQFMIADMAINLELSRLFTYRAAAEVDSYGVSSYNASIAKCFAA 346

  Fly   359 DMANKIASDAVQIFGGNGFNSEYPVEKLMRDAKIYQIYEGTSQIQRLIISRNMYE 413
            |.||..|::|.|||||.|||.|||||||||||||||||||||||||::|.|.:::
Worm   347 DTANVAATNACQIFGGAGFNCEYPVEKLMRDAKIYQIYEGTSQIQRMVIGRTLFQ 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcad	NP_648149.1	CaiA	35..411	CDD:224871	235/375 (63%)
Mcad	NP_648149.1	MCAD	37..414	CDD:173846	234/377 (62%)
acdh-8	NP_495142.1	CaiA	21..400	CDD:224871	236/377 (63%)
acdh-8	NP_495142.1	ACAD	25..400	CDD:299127	234/374 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I1615
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3
Inparanoid	1	1.050	493	1.000	Inparanoid score	I770
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56625
OrthoDB	1	1.010	-	-		D281661at33208
OrthoFinder	1	1.000	-	-		FOG0005377
OrthoInspector	1	1.000	-	-		otm14066
orthoMCL	1	0.900	-	-		OOG6_101120
Panther	1	1.100	-	-	O	PTHR48083
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3813
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840