DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcad and Acadm

DIOPT Version :9

Sequence 1:	NP_648149.1	Gene:	Mcad / 38864	FlyBaseID:	FBgn0035811	Length:	419	Species:	Drosophila melanogaster
Sequence 2:	NP_031408.1	Gene:	Acadm / 11364	MGIID:	87867	Length:	421	Species:	Mus musculus

Alignment Length:	385	Identity:	283/385 - (73%)
Similarity:	326/385 - (84%)	Gaps:	0/385 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GTSFALTEDQLQLQELARKFTREEIIPVAAQYDKSGEYPWPIIKKAWELGLMNNHIPADIGGLDL 96
            |.||.|||.|.:.|..||||.||||||||.:||||||||:|:||:||||||:|.|||...|||.|
Mouse    36 GFSFELTEQQKEFQATARKFAREEIIPVAPEYDKSGEYPFPLIKRAWELGLINAHIPESCGGLGL 100

  Fly    97 DVFTTCLSAEELAYGCTGIMTALEASGLGQTPVILSGNKEQKKKYLGRLLEEPLVAAYCVTEPGA 161
            ..|..||..|||||||||:.||:||:.|||.||||:||.:||||||||:.|:|::.|||||||.|
Mouse   101 GTFDACLITEELAYGCTGVQTAIEANSLGQMPVILAGNDQQKKKYLGRMTEQPMMCAYCVTEPSA 165

  Fly   162 GSDVSGIKTRAEKKGDEWVINGQKMWITNGGVANWYFVLARTNPDPKCPPSKAFTGFIVERDSPG 226
            ||||:.|||:|||||||:|||||||||||||.|||||:|||:|||||.|.||||||||||.|:||
Mouse   166 GSDVAAIKTKAEKKGDEYVINGQKMWITNGGKANWYFLLARSNPDPKVPASKAFTGFIVEADTPG 230

  Fly   227 LTPGRKELNMGQRASDTRGITFEDVRVPKENVLIGEGAGFKIAMGTFDKTRPPVAAGAVGLAQRC 291
            :..|:||||||||.||||||.||||||||||||||||||||||||.||:|||.|||||||||||.
Mouse   231 IHIGKKELNMGQRCSDTRGIAFEDVRVPKENVLIGEGAGFKIAMGAFDRTRPTVAAGAVGLAQRA 295

  Fly   292 LDEALKYALERKTFGVPIAYHQAVQFMLADMAIGVETSRLAWRLSAWEIDQGRRNSYYASIAKCH 356
            ||||.||||:|||||..:..||.|.|:||:||:.||.:||:::.:|||:|.||||:|||||||..
Mouse   296 LDEATKYALDRKTFGKLLVEHQGVSFLLAEMAMKVELARLSYQRAAWEVDSGRRNTYYASIAKAF 360

  Fly   357 AADMANKIASDAVQIFGGNGFNSEYPVEKLMRDAKIYQIYEGTSQIQRLIISRNMYEAAK 416
            |.|:||::|:||||||||.|||:||||||||||||||||||||:|||||||:|...|..|
Mouse   361 AGDIANQLATDAVQIFGGYGFNTEYPVEKLMRDAKIYQIYEGTAQIQRLIIAREHIEKYK 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcad	NP_648149.1	CaiA	35..411	CDD:224871	279/375 (74%)
Mcad	NP_648149.1	MCAD	37..414	CDD:173846	278/376 (74%)
Acadm	NP_031408.1	CaiA	39..420	CDD:224871	280/380 (74%)
		MCAD	41..418	CDD:173846	278/376 (74%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P41367	278..281		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2575
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3
Inparanoid	1	1.050	582	1.000	Inparanoid score	I1006
Isobase	1	0.950	-	0	Normalized mean entropy	S2116
OMA	1	1.010	-	-		QHG56625
OrthoDB	1	1.010	-	-		D281661at33208
OrthoFinder	1	1.000	-	-		FOG0005377
OrthoInspector	1	1.000	-	-		oto94742
orthoMCL	1	0.900	-	-		OOG6_101120
Panther	1	1.100	-	-	LDO	PTHR48083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3931
SonicParanoid	1	1.000	-	-		X3813
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.820