DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank2 and ANKRD53

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:NP_001108588.1 Gene:ANKRD53 / 79998 HGNCID:25691 Length:530 Species:Homo sapiens


Alignment Length:347 Identity:85/347 - (24%)
Similarity:130/347 - (37%) Gaps:55/347 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   435 RGE--------TPLHLAARANQTDIIRILLRNGAQVDARAREQQTPL-HIASRLGNVDIVMLLLQ 490
            |||        ||.....:||:..:      .....||.:::...|| .:|..|......:...:
Human    20 RGEGRGARPQPTPSGSMQQANKVSL------KATWTDAESKQPSQPLPDLADHLSAQATALARPR 78

  Fly   491 HGAQ------------------VDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFT 537
            ..|.                  :|.|....|..| .||..|..|.....:...........||||
Human    79 RPASLTPPRADPSPSKESDQTAIDQTAIGSYYQL-FAAAVGNVEWLRFCLNQSLREIPTDDKGFT 142

  Fly   538 PLHLTAKYGHIKVAQLLLQK-EADVDAQGKNGVTPLHVACHYNNQQVAL----LLLEKGASPHAT 597
            .:|..|::|.:...|:|::: :..||....|..||||:..|.:|..|||    .||||||..:|.
Human   143 AIHFAAQWGKLACLQVLVEEYKFPVDLLTNNSQTPLHLVIHRDNTTVALPCIYYLLEKGADLNAQ 207

  Fly   598 AKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLL------IEH 656
            ..||.||||:|||...:|....|::.||..:|:...|:.|:.......|...:..|      .:.
Human   208 TCNGSTPLHLAARDGLLDCVKVLVQSGANVHAQDAMGYKPIDFCKIWNHRACARFLKDAMWKKDK 272

  Fly   657 KAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQ 721
            |.......|..:....|...|.|.    ::|....:..:...|....||...|.|.:      |.
Human   273 KDFAREMTKMKMFKSQLTLMEHNY----LIEYQKEHKILREAAIRKWLHGKLHPGHS------LV 327

  Fly   722 NGANVDAATSIGYTPLHQTAQQ 743
            :......||::..||..:.:|:
Human   328 SNTKQARATALSKTPEQRESQR 349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786
Ank_4 11..64 CDD:290365
ANK 38..163 CDD:238125
ANK repeat 43..74 CDD:293786
Ank_2 48..135 CDD:289560
ANK repeat 76..107 CDD:293786
ANK repeat 109..134 CDD:293786
Ank_4 110..163 CDD:290365
Ank_4 172..225 CDD:290365
ANK repeat 175..202 CDD:293786
ANK 199..324 CDD:238125
ANK repeat 204..235 CDD:293786
Ank_2 209..300 CDD:289560
ANK repeat 237..268 CDD:293786
ANK 266..390 CDD:238125
ANK repeat 270..300 CDD:293786
ANK repeat 303..367 CDD:293786
Ank_2 308..399 CDD:289560
ANK 364..489 CDD:238125 13/62 (21%)
ANK repeat 369..400 CDD:293786
ANK repeat 402..433 CDD:293786
Ank_4 403..456 CDD:290365 7/28 (25%)
ANK repeat 435..466 CDD:293786 9/38 (24%)
Ank_2 440..530 CDD:289560 17/108 (16%)
ANK 463..588 CDD:238125 36/148 (24%)
ANK repeat 468..497 CDD:293786 5/47 (11%)
ANK repeat 501..530 CDD:293786 6/28 (21%)
Ank_2 506..597 CDD:289560 32/95 (34%)
ANK 529..654 CDD:238125 46/135 (34%)
ANK repeat 535..565 CDD:293786 10/30 (33%)
ANK repeat 567..598 CDD:293786 17/34 (50%)
Ank_2 572..661 CDD:289560 33/98 (34%)
ANK repeat 600..630 CDD:293786 13/29 (45%)
ANK repeat 633..662 CDD:293786 5/34 (15%)
ANK 661..785 CDD:238125 16/83 (19%)
ANK repeat 666..697 CDD:293786 4/30 (13%)
Ank_2 672..762 CDD:289560 15/72 (21%)
ANK repeat 699..730 CDD:293786 6/30 (20%)
ANK repeat 732..762 CDD:293786 3/12 (25%)
ZU5 927..1030 CDD:128514
Death_ank 1417..1497 CDD:260029
ER-remodelling 11936..>12013 CDD:258892
ANKRD53NP_001108588.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..99 14/84 (17%)
Ank_4 112..160 CDD:290365 13/48 (27%)
ANK 136..263 CDD:238125 45/126 (36%)
ANK 1 139..169 10/29 (34%)
ANK repeat 140..171 CDD:293786 10/30 (33%)
Ank_2 144..241 CDD:289560 38/96 (40%)
ANK repeat 173..208 CDD:293786 17/34 (50%)
ANK 2 173..206 16/32 (50%)
ANK repeat 210..241 CDD:293786 14/30 (47%)
ANK 3 210..239 13/28 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..360 7/33 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 383..402
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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