DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank2 and ank1b

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:XP_021329092.1 Gene:ank1b / 797662 ZFINID:ZDB-GENE-091113-6 Length:2091 Species:Danio rerio


Alignment Length:1911 Identity:823/1911 - (43%)
Similarity:1149/1911 - (60%) Gaps:278/1911 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 TENG-----AQGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSE 62
            |:.|     .:.|..||||||||:||||:.|:|:||.||||.:|.||||.||||||:||:.:|.|
Zfish    65 TQGGKWHFDGRADATTSFLRAARSGNLEKALDHIKNGIDINIANQNGLNGLHLASKEGHVKMVLE 129

  Fly    63 LLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVR 127
            ||..|..:::.|||||||||||:|||||:||..|:.:.|:||.|||.||:||||||||||..||:
Zfish   130 LLHNGIDLETTTKKGNTALHIAALAGQEKVVAELINYGANVNAQSQKGFSPLYMAAQENHLEVVK 194

  Fly   128 LLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLL 192
            .||.:||||||.|||||||||||:||||:.|||:|:...|:||||||||||||:.||.:.|.:||
Zfish   195 YLLEHGANQSLPTEDGFTPLAVALQQGHENVVALLINYGTKGKVRLPALHIAARNDDTRTAAVLL 259

  Fly   193 DNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLL 257
            .||.||||.||:||||||||:||.|.::|.||:.:||:||::.|:.|:|||:|::.|...||.||
Zfish   260 QNDPNPDVLSKTGFTPLHIAAHYENLSVAQLLLNRGANVNFTPKNGITPLHIASRRGNVIMVRLL 324

  Fly   258 LEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARI 322
            |::|..|:|||:|.|||||||||:||.:||::||::|||:.|||||||:|:||||||:|:|..|.
Zfish   325 LDRGAQIDAKTKDELTPLHCAARNGHVRVVEILLDQGAPLQAKTKNGLSPIHMAAQGDHMDCVRQ 389

  Fly   323 LLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVE 387
            ||.:.|.:|::|:|:||.|||||||||.|:.|:|||:.|.|||||||||||||||||||.::.::
Zfish   390 LLQYNAEIDDITLDHLTPLHVAAHCGHHRMVKVLLDKGAKANARALNGFTPLHIACKKNHMRSMD 454

  Fly   388 LLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDII 452
            |||:|.||:.|.|||||||||||||||.:|||..|||..|||:...|:.|||||:||||...::.
Zfish   455 LLLKHSASLEAVTESGLTPLHVAAFMGHLNIVKSLLQRGASPNASNVKVETPLHMAARAGHCEVA 519

  Fly   453 RILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEV 517
            :.||:|.|||||:|::.|||||.|:|:|:.::|.||::|.|..|:.|...:|.|||||:||..:.
Zfish   520 QFLLQNNAQVDAKAKDDQTPLHCAARMGHKELVKLLMEHKANPDSATTAGHTPLHIAAREGHAQT 584

  Fly   518 AAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQ 582
            ..:|::..|.....|||||||||:..|||.:.||:|||::.|:.:|.||||:||||||.|:||..
Zfish   585 TRILLDENAQQTKMTKKGFTPLHVACKYGKVDVAELLLERGANPNAAGKNGLTPLHVAVHHNNLD 649

  Fly   583 VALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHA 647
            |..||:.||.|||:||:||:|.|||||::||:::|::||:|||.||:||..|.|||||:||||..
Zfish   650 VVKLLVSKGGSPHSTARNGYTALHIAAKQNQLEVASSLLQYGANANSESLQGITPLHLASQEGQP 714

  Fly   648 EISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQ 712
            ::..|||..:|.||...||||||:||.|||.:|.:|::|.|.||::..|::.||||||||.|:|.
Zfish   715 DMVALLISKQANVNLGNKNGLTPLHLVAQEGHVGIADMLVKQGASVYAASRMGYTPLHVACHYGN 779

  Fly   713 ANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLG 777
            ..||:||||..|:|::.|.:|||||||.|||||..||.|||:|.|..|..|.||.:||.||::||
Zfish   780 IKMVKFLLQQQAHVNSKTRLGYTPLHQAAQQGHTDIVTLLLKHGALPNEITTNGTSPLGIAKRLG 844

  Fly   778 YISVLDSLKTITKEDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEGGE-----DNMLSDQPYR 837
            ||||:|.||.:|:|..:..    ..||:|:..||.:.| .:..||:||..     |.:|.....|
Zfish   845 YISVIDVLKLVTEESVSMI----TTEKHRMSFPETVDE-ILDVSEDEGVAQLTLGDELLGMDGAR 904

  Fly   838 YLTVDEMKS--------------------------------------LGDDSLPIDVTR------ 858
            ||.:|::|.                                      :||:.|.:|..|      
Zfish   905 YLKLDDLKDQDDDFLSPKKTLRDFESGMGTTNQFSRISVCDIYFVPYVGDELLGMDGARYLKLDD 969

  Fly   859 -----DERMDSNRMTQSAEYASGVP------------------------PTIGEEV--------- 885
                 |:.:...:..:..|...|..                        |.:|:|:         
Zfish   970 LKDQDDDFLSPKKTLRDFESGMGTTMSFSSFLFLFLPVSRISVCDIYFVPYVGDELLGMDGARYL 1034

  Fly   886 ------------ISPHKT---------------------------------------------QV 893
                        :||.||                                             .:
Zfish  1035 KLDDLKDQDDDFLSPKKTLRDFESGMGTTPYSPAIPRIPCVSPETVMLDQHTPVPLPKEYDEDSL 1099

  Fly   894 YGSSPKA-TVDGVYIANGSGHDEPPHVGRKLSWKSFLVSFLVDARGGAMRGCRHSGVRMIIPSRS 957
            ..|||.. |.|.|     |....|.|.|       |||||:||||||:|||.||:|:|:|||.|:
Zfish  1100 IPSSPATETSDNV-----SPVASPIHTG-------FLVSFMVDARGGSMRGSRHNGLRVIIPPRT 1152

  Fly   958 TCQPTRVTCRYVKPQRTMHPPQLMEGEALASRVLELGPCSTKFIGPVVMEVPHFASLRGKEREII 1022
            ...|||:|||.||||:...||.|:|||.||||::.|||.|.:|:|||::|:||||||...:||::
Zfish  1153 CAAPTRITCRLVKPQKLTTPPPLVEGEGLASRIISLGPSSMQFLGPVIVEIPHFASLSRGDRELV 1217

  Fly  1023 ILRSDNGETWREHTIDNSEEIIHDVLQQCFEPEEIAQLEEQAGNHVCRFVTYDFPQYFAVVSRIR 1087
            :|||:||..|:||.....::::..:|...  .|::...||.....:.|.::.|||.|||||||:|
Zfish  1218 VLRSENGSVWKEHRNRYGDDVLETILNGM--DEDLESQEELEKKRIRRIISTDFPLYFAVVSRVR 1280

  Fly  1088 QEVHAIGPEGGMVSSTVVPQVQAVFPQGALTKKIKVGLQAQPVDPDLTAKLLGRGVAVSPIVTVE 1152
            ||...||||||.::|.:||||||:||..|:||::::||||||:..:|..:.||.....||:||||
Zfish  1281 QESDLIGPEGGQLASKLVPQVQAIFPDTAVTKRVRLGLQAQPIPDELLTRQLGNQATFSPVVTVE 1345

  Fly  1153 PRRRKFHKAITLSMPAPKAHSQGMINQYSGNTPTLRLLCSITGGPSRAQWEDVTGSTPLTFVNDC 1217
            |||||||:.|.|.:|.|.:..:...:...|:|.:||||||:.||.:.|||||:||:|.|.:.::|
Zfish  1346 PRRRKFHRPIGLRIPLPPSWRESPRDAGEGDTTSLRLLCSVIGGTAPAQWEDITGTTKLMYSHNC 1410

  Fly  1218 VSFTTTVSARFWLMDCRNISDATKMATELYKEVIHVPFIAKFVVFAKKVEPFEAKLRVFCMTDDR 1282
            .:|||.|||||||.||...::|...|..||:|::.||::||||||||..:..|.:||.:|||||:
Zfish  1411 ANFTTNVSARFWLADCPRTAEAVTFANLLYRELMSVPYMAKFVVFAKMNDAREGRLRCYCMTDDK 1475

  Fly  1283 EDKTLEKHELYTEVAKSRDVEVLEGKPQYIEMAGNLVPVTKSGDQ-LQVQFKAFRENRLPFTVRV 1346
            .|||||.||.::|||:|||:||:||.|.::|.:||||||.|:..| ....|:|||:||||.:|:|
Zfish  1476 IDKTLELHENFSEVARSRDIEVMEGMPLHLECSGNLVPVRKATQQPRSFSFQAFRDNRLPVSVKV 1540

  Fly  1347 KDQHADIVGRTLFMKEPKVAKGEPPQQPICILNIVLPEAV----IPD-----STTAFSDRVTSAY 1402
            :|.:.:..|...|::  |..|.|..|..:|.|||.:|..|    ..|     :..|..:|.::..
Zfish  1541 RDANKEASGFLSFLR--KSTKYEDTQHVLCNLNITMPPCVKGVGSDDRRRTLTPLALRERYSALS 1603

  Fly  1403 RTSMFSLSKHQNDHYIGDIRIVDLSNLLGKDWIQLAPEIGINGEEIDEIINQNTDSIARQAQSMI 1467
            ...:.:::..:..    :::|..::..||..|.:||.|:....::|:.|..:|.:|:..|:.:::
Zfish  1604 EPGLAAVNAMERT----ELKITVIAEQLGLSWTELARELQFGVDDINRIRVENPNSLLDQSSALL 1664

  Fly  1468 RLY--KDKPNYDILSLETALKNIGRDDIMKKCKSGRLSHSREFDEADLMKNSESVEE----LVRR 1526
            .|:  ::.....:.||..|||||.|.||: ||        .|.....::  .|::||    ||.|
Zfish  1665 NLWVGREGKKAKMESLYGALKNIDRSDIV-KC--------LEAQAPPVL--PETLEEGACRLVDR 1718

  Fly  1527 ESKRI------------QQINEREEVKYS-----AEEKEVEESESDEEAAKRTVAERREKIVKRL 1574
            :|..:            :::.....::||     ..|...:|..|.|.|   .:|...|..:..:
Zfish  1719 DSTLLSPSVVNGYGLVQEELLSPASMQYSLPSPLGVEPYWQEVSSLECA---PIATTEEDTMLEM 1780

  Fly  1575 SIERSIPASTQKKEITREITEIKRKSLIEDKKAHHESEILMQLPADNVIIKTTTVPDQVIKMKMG 1639
            |..:..||......:|.|.:.:...|..:|.:.:     .:.||..:                :|
Zfish  1781 SDVQVWPAGVSPSLVTVEDSSLDGSSRADDSEGN-----TLSLPCSS----------------LG 1824

  Fly  1640 KMDSTEVSKSEFDKELTHKFKTSGRSSEEEDQPSYPDQTDKIVQDISA-AEK------------- 1690
            :..|.....|....||           |||::....::.|...:.:|| |||             
Zfish  1825 RPSSGASGASGSIMEL-----------EEEEEEEEIEEDDIQHEPVSASAEKAWASGAVPKANYN 1878

  Fly  1691 ----------KEKDGVTFSRVTTITR 1706
                      |..|....|.:|::.|
Zfish  1879 GQAGGQRSEGKRTDAAAGSSMTSVAR 1904

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786 21/30 (70%)
Ank_4 11..64 CDD:290365 35/52 (67%)
ANK 38..163 CDD:238125 84/124 (68%)
ANK repeat 43..74 CDD:293786 17/30 (57%)
Ank_2 48..135 CDD:289560 55/86 (64%)
ANK repeat 76..107 CDD:293786 20/30 (67%)
ANK repeat 109..134 CDD:293786 16/24 (67%)
Ank_4 110..163 CDD:290365 40/52 (77%)
Ank_4 172..225 CDD:290365 35/52 (67%)
ANK repeat 175..202 CDD:293786 17/26 (65%)
ANK 199..324 CDD:238125 75/124 (60%)
ANK repeat 204..235 CDD:293786 18/30 (60%)
Ank_2 209..300 CDD:289560 50/90 (56%)
ANK repeat 237..268 CDD:293786 14/30 (47%)
ANK 266..390 CDD:238125 82/123 (67%)
ANK repeat 270..300 CDD:293786 19/29 (66%)
ANK repeat 303..367 CDD:293786 39/63 (62%)
Ank_2 308..399 CDD:289560 57/90 (63%)
ANK 364..489 CDD:238125 78/124 (63%)
ANK repeat 369..400 CDD:293786 20/30 (67%)
ANK repeat 402..433 CDD:293786 22/30 (73%)
Ank_4 403..456 CDD:290365 31/52 (60%)
ANK repeat 435..466 CDD:293786 17/30 (57%)
Ank_2 440..530 CDD:289560 40/89 (45%)
ANK 463..588 CDD:238125 62/124 (50%)
ANK repeat 468..497 CDD:293786 13/28 (46%)
ANK repeat 501..530 CDD:293786 10/28 (36%)
Ank_2 506..597 CDD:289560 49/90 (54%)
ANK 529..654 CDD:238125 73/124 (59%)
ANK repeat 535..565 CDD:293786 16/29 (55%)
ANK repeat 567..598 CDD:293786 19/30 (63%)
Ank_2 572..661 CDD:289560 51/88 (58%)
ANK repeat 600..630 CDD:293786 18/29 (62%)
ANK repeat 633..662 CDD:293786 15/28 (54%)
ANK 661..785 CDD:238125 72/123 (59%)
ANK repeat 666..697 CDD:293786 16/30 (53%)
Ank_2 672..762 CDD:289560 51/89 (57%)
ANK repeat 699..730 CDD:293786 18/30 (60%)
ANK repeat 732..762 CDD:293786 20/29 (69%)
ZU5 927..1030 CDD:128514 63/102 (62%)
Death_ank 1417..1497 CDD:260029 23/81 (28%)
ER-remodelling 11936..>12013 CDD:258892
ank1bXP_021329092.1 ANK repeat 80..108 CDD:293786 20/27 (74%)
ANK 105..230 CDD:238125 84/124 (68%)
ANK repeat 110..141 CDD:293786 17/30 (57%)
ANK repeat 144..174 CDD:293786 19/29 (66%)
ANK repeat 176..207 CDD:293786 22/30 (73%)
ANK repeat 209..233 CDD:293786 17/23 (74%)
ANK repeat 242..269 CDD:293786 17/26 (65%)
ANK 266..391 CDD:238125 75/124 (60%)
ANK repeat 272..302 CDD:293786 18/29 (62%)
ANK repeat 304..335 CDD:293786 14/30 (47%)
ANK repeat 337..367 CDD:293786 19/29 (66%)
ANK repeat 370..401 CDD:293786 17/30 (57%)
Ank_4 371..424 CDD:316185 31/52 (60%)
ANK repeat 403..433 CDD:293786 20/29 (69%)
ANK 431..556 CDD:238125 78/124 (63%)
ANK repeat 436..467 CDD:293786 20/30 (67%)
ANK repeat 469..500 CDD:293786 22/30 (73%)
ANK repeat 502..533 CDD:293786 17/30 (57%)
ANK 530..655 CDD:238125 62/124 (50%)
ANK repeat 535..563 CDD:293786 13/27 (48%)
ANK repeat 569..599 CDD:293786 10/29 (34%)
ANK 600..721 CDD:238125 72/120 (60%)
ANK repeat 601..632 CDD:293786 17/30 (57%)
ANK repeat 634..662 CDD:293786 17/27 (63%)
ANK repeat 667..695 CDD:293786 16/27 (59%)
ANK 695..820 CDD:238125 71/124 (57%)
ANK repeat 700..731 CDD:293786 16/30 (53%)
ANK repeat 733..764 CDD:293786 16/30 (53%)
ANK repeat 766..797 CDD:293786 18/30 (60%)
ANK repeat 799..827 CDD:293786 19/27 (70%)
Ank_4 800..852 CDD:316185 34/51 (67%)
ZU5 1121..1225 CDD:128514 64/110 (58%)
Death_ank1 1614..1697 CDD:260067 25/95 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593756
Domainoid 1 1.000 139 1.000 Domainoid score I4734
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1011028at2759
OrthoFinder 1 1.000 - - FOG0000917
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100012
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
76.650

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