DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank2 and ank1b

DIOPT Version :10

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:XP_021324740.2 Gene:ank1b / 797662 ZFINID:ZDB-GENE-091113-6 Length:1963 Species:Danio rerio


Alignment Length:1787 Identity:821/1787 - (45%)
Similarity:1143/1787 - (63%) Gaps:158/1787 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 TENG-----AQGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSE 62
            |:.|     .:.|..||||||||:||||:.|:|:||.||||.:|.||||.||||||:||:.:|.|
Zfish    65 TQGGKWHFDGRADATTSFLRAARSGNLEKALDHIKNGIDINIANQNGLNGLHLASKEGHVKMVLE 129

  Fly    63 LLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVR 127
            ||..|..:::.|||||||||||:|||||:||..|:.:.|:||.|||.||:||||||||||..||:
Zfish   130 LLHNGIDLETTTKKGNTALHIAALAGQEKVVAELINYGANVNAQSQKGFSPLYMAAQENHLEVVK 194

  Fly   128 LLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLL 192
            .||.:||||||.|||||||||||:||||:.|||:|:...|:||||||||||||:.||.:.|.:||
Zfish   195 YLLEHGANQSLPTEDGFTPLAVALQQGHENVVALLINYGTKGKVRLPALHIAARNDDTRTAAVLL 259

  Fly   193 DNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLL 257
            .||.||||.||:||||||||:||.|.::|.||:.:||:||::.|:.|:|||:|::.|...||.||
Zfish   260 QNDPNPDVLSKTGFTPLHIAAHYENLSVAQLLLNRGANVNFTPKNGITPLHIASRRGNVIMVRLL 324

  Fly   258 LEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARI 322
            |::|..|:|||:|.|||||||||:||.:||::||::|||:.|||||||:|:||||||:|:|..|.
Zfish   325 LDRGAQIDAKTKDELTPLHCAARNGHVRVVEILLDQGAPLQAKTKNGLSPIHMAAQGDHMDCVRQ 389

  Fly   323 LLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVE 387
            ||.:.|.:|::|:|:||.|||||||||.|:.|:|||:.|.|||||||||||||||||||.::.::
Zfish   390 LLQYNAEIDDITLDHLTPLHVAAHCGHHRMVKVLLDKGAKANARALNGFTPLHIACKKNHMRSMD 454

  Fly   388 LLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDII 452
            |||:|.||:.|.|||||||||||||||.:|||..|||..|||:...|:.|||||:||||...::.
Zfish   455 LLLKHSASLEAVTESGLTPLHVAAFMGHLNIVKSLLQRGASPNASNVKVETPLHMAARAGHCEVA 519

  Fly   453 RILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEV 517
            :.||:|.|||||:|::.|||||.|:|:|:.::|.||::|.|..|:.|...:|.|||||:||..:.
Zfish   520 QFLLQNNAQVDAKAKDDQTPLHCAARMGHKELVKLLMEHKANPDSATTAGHTPLHIAAREGHAQT 584

  Fly   518 AAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQ 582
            ..:|::..|.....|||||||||:..|||.:.||:|||::.|:.:|.||||:||||||.|:||..
Zfish   585 TRILLDENAQQTKMTKKGFTPLHVACKYGKVDVAELLLERGANPNAAGKNGLTPLHVAVHHNNLD 649

  Fly   583 VALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHA 647
            |..||:.||.|||:||:||:|.|||||::||:::|::||:|||.||:||..|.|||||:||||..
Zfish   650 VVKLLVSKGGSPHSTARNGYTALHIAAKQNQLEVASSLLQYGANANSESLQGITPLHLASQEGQP 714

  Fly   648 EISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQ 712
            ::..|||..:|.||...||||||:||.|||.:|.:|::|.|.||::..|::.||||||||.|:|.
Zfish   715 DMVALLISKQANVNLGNKNGLTPLHLVAQEGHVGIADMLVKQGASVYAASRMGYTPLHVACHYGN 779

  Fly   713 ANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLG 777
            ..||:||||..|:|::.|.:|||||||.|||||..||.|||:|.|..|..|.||.:||.||::||
Zfish   780 IKMVKFLLQQQAHVNSKTRLGYTPLHQAAQQGHTDIVTLLLKHGALPNEITTNGTSPLGIAKRLG 844

  Fly   778 YISVLDSLKTITKEDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEGGE-----DNMLSDQPYR 837
            ||||:|.||.:|:|..:..    ..||:|:..||.:.| .:..||:||..     |.:|.....|
Zfish   845 YISVIDVLKLVTEESVSMI----TTEKHRMSFPETVDE-ILDVSEDEGVAQLTLGDELLGMDGAR 904

  Fly   838 YLTVDEMKSLGDDSL-PIDVTRDERMDSNRMTQSAEYASGVP--PTIGEEVI-----SP------ 888
            ||.:|::|...||.| |....||  .:|...|  ..|:..:|  |.:..|.:     :|      
Zfish   905 YLKLDDLKDQDDDFLSPKKTLRD--FESGMGT--TPYSPAIPRIPCVSPETVMLDQHTPVPLPKE 965

  Fly   889 -HKTQVYGSSPKA-TVDGVYIANGSGHDEPPHVGRKLSWKSFLVSFLVDARGGAMRGCRHSGVRM 951
             .:..:..|||.. |.|.|     |....|.|.|       |||||:||||||:|||.||:|:|:
Zfish   966 YDEDSLIPSSPATETSDNV-----SPVASPIHTG-------FLVSFMVDARGGSMRGSRHNGLRV 1018

  Fly   952 IIPSRSTCQPTRVTCRYVKPQRTMHPPQLMEGEALASRVLELGPCSTKFIGPVVMEVPHFASLRG 1016
            |||.|:...|||:|||.||||:...||.|:|||.||||::.|||.|.:|:|||::|:||||||..
Zfish  1019 IIPPRTCAAPTRITCRLVKPQKLTTPPPLVEGEGLASRIISLGPSSMQFLGPVIVEIPHFASLSR 1083

  Fly  1017 KEREIIILRSDNGETWREHTIDNSEEIIHDVLQQCFEPEEIAQLEEQAGNHVCRFVTYDFPQYFA 1081
            .:||:::|||:||..|:||.....::::..:|...  .|::...||.....:.|.::.|||.|||
Zfish  1084 GDRELVVLRSENGSVWKEHRNRYGDDVLETILNGM--DEDLESQEELEKKRIRRIISTDFPLYFA 1146

  Fly  1082 VVSRIRQEVHAIGPEGGMVSSTVVPQVQAVFPQGALTKKIKVGLQAQPVDPDLTAKLLGRGVAVS 1146
            ||||:|||...||||||.::|.:||||||:||..|:||::::||||||:..:|..:.||.....|
Zfish  1147 VVSRVRQESDLIGPEGGQLASKLVPQVQAIFPDTAVTKRVRLGLQAQPIPDELLTRQLGNQATFS 1211

  Fly  1147 PIVTVEPRRRKFHKAITLSMPAPKAHSQGMINQYSGNTPTLRLLCSITGGPSRAQWEDVTGSTPL 1211
            |:|||||||||||:.|.|.:|.|.:..:...:...|:|.:||||||:.||.:.|||||:||:|.|
Zfish  1212 PVVTVEPRRRKFHRPIGLRIPLPPSWRESPRDAGEGDTTSLRLLCSVIGGTAPAQWEDITGTTKL 1276

  Fly  1212 TFVNDCVSFTTTVSARFWLMDCRNISDATKMATELYKEVIHVPFIAKFVVFAKKVEPFEAKLRVF 1276
            .:.::|.:|||.|||||||.||...::|...|..||:|::.||::||||||||..:..|.:||.:
Zfish  1277 MYSHNCANFTTNVSARFWLADCPRTAEAVTFANLLYRELMSVPYMAKFVVFAKMNDAREGRLRCY 1341

  Fly  1277 CMTDDREDKTLEKHELYTEVAKSRDVEVLEGKPQYIEMAGNLVPVTKSGDQ-LQVQFKAFRENRL 1340
            |||||:.|||||.||.::|||:|||:||:||.|.::|.:||||||.|:..| ....|:|||:|||
Zfish  1342 CMTDDKIDKTLELHENFSEVARSRDIEVMEGMPLHLECSGNLVPVRKATQQPRSFSFQAFRDNRL 1406

  Fly  1341 PFTVRVKDQHADIVGRTLFMKEPKVAKGEPPQQPICILNIVLPEAV----IPD-----STTAFSD 1396
            |.:|:|:|.:.:..|...|::  |..|.|..|..:|.|||.:|..|    ..|     :..|..:
Zfish  1407 PVSVKVRDANKEASGFLSFLR--KSTKYEDTQHVLCNLNITMPPCVKGVGSDDRRRTLTPLALRE 1469

  Fly  1397 RVTSAYRTSMFSLSKHQNDHYIGDIRIVDLSNLLGKDWIQLAPEIGINGEEIDEIINQNTDSIAR 1461
            |.::.....:.:::..:..    :::|..::..||..|.:||.|:....::|:.|..:|.:|:..
Zfish  1470 RYSALSEPGLAAVNAMERT----ELKITVIAEQLGLSWTELARELQFGVDDINRIRVENPNSLLD 1530

  Fly  1462 QAQSMIRLY--KDKPNYDILSLETALKNIGRDDIMKKCKSGRLSHSREFDEADLMKNSESVEE-- 1522
            |:.:::.|:  ::.....:.||..|||||.|.||: ||        .|.....::  .|::||  
Zfish  1531 QSSALLNLWVGREGKKAKMESLYGALKNIDRSDIV-KC--------LEAQAPPVL--PETLEEGA 1584

  Fly  1523 --LVRRESKRI------------QQINEREEVKYS-----AEEKEVEESESDEEAAKRTVAERRE 1568
              ||.|:|..:            :::.....::||     ..|...:|..|.|.|   .:|...|
Zfish  1585 CRLVDRDSTLLSPSVVNGYGLVQEELLSPASMQYSLPSPLGVEPYWQEVSSLECA---PIATTEE 1646

  Fly  1569 KIVKRLSIERSIPASTQKKEITREITEIKRKSLIEDKKAHHESEILMQLPADNVIIKTTTVPDQV 1633
            ..:..:|..:..||......:|.|.:.:...|..:|.:.:     .:.||..:            
Zfish  1647 DTMLEMSDVQVWPAGVSPSLVTVEDSSLDGSSRADDSEGN-----TLSLPCSS------------ 1694

  Fly  1634 IKMKMGKMDSTEVSKSEFDKELTHKFKTSGRSSEEEDQPSYPDQTDKIVQDISA-AEK------- 1690
                :|:..|.....|....||           |||::....::.|...:.:|| |||       
Zfish  1695 ----LGRPSSGASGASGSIMEL-----------EEEEEEEEIEEDDIQHEPVSASAEKAWASGAV 1744

  Fly  1691 ----------------KEKDGVTFSRVTTITR 1706
                            |..|....|.:|::.|
Zfish  1745 PKANYNGQAGGQRSEGKRTDAAAGSSMTSVAR 1776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANKYR 10..308 CDD:440430 192/297 (65%)
ANK repeat 10..41 CDD:293786 21/30 (70%)
ANK repeat 43..74 CDD:293786 17/30 (57%)
ANK repeat 76..107 CDD:293786 20/30 (67%)
ANK repeat 109..134 CDD:293786 16/24 (67%)
ANK repeat 175..202 CDD:293786 17/26 (65%)
ANKYR 190..473 CDD:440430 175/282 (62%)
ANK repeat 204..235 CDD:293786 18/30 (60%)
ANK repeat 237..268 CDD:293786 14/30 (47%)
ANK repeat 270..300 CDD:293786 19/29 (66%)
ANK repeat 303..367 CDD:293786 39/63 (62%)
ANK repeat 369..400 CDD:293786 20/30 (67%)
ANKYR 383..671 CDD:440430 158/287 (55%)
ANK repeat 402..433 CDD:293786 22/30 (73%)
ANK repeat 435..466 CDD:293786 17/30 (57%)
ANK repeat 468..497 CDD:293786 13/28 (46%)
ANK repeat 501..530 CDD:293786 10/28 (36%)
ANK repeat 535..565 CDD:293786 16/29 (55%)
ANK repeat 567..598 CDD:293786 19/30 (63%)
PHA03100 599..>773 CDD:476869 98/173 (57%)
ANK repeat 600..630 CDD:293786 18/29 (62%)
ANK repeat 633..662 CDD:293786 15/28 (54%)
ANK repeat 666..697 CDD:293786 16/30 (53%)
ANK repeat 699..730 CDD:293786 18/30 (60%)
ANK repeat 732..762 CDD:293786 20/29 (69%)
ZU5 930..1027 CDD:459941 59/96 (61%)
UPA_2 1253..1384 CDD:375346 66/131 (50%)
Death_ank 1417..1497 CDD:260029 23/81 (28%)
PTZ00121 <1443..2235 CDD:173412 63/311 (20%)
PTZ00449 <3292..3611 CDD:185628
PTZ00449 <4400..4857 CDD:185628
PTZ00449 <4908..5267 CDD:185628
PTZ00108 <5179..5374 CDD:240271
PTZ00108 <6034..6230 CDD:240271
PTZ00449 <6620..6979 CDD:185628
PTZ00108 <7119..7314 CDD:240271
PTZ00108 <7347..7544 CDD:240271
PTZ00108 <7651..7848 CDD:240271
PTZ00449 <7804..8119 CDD:185628
PTZ00108 <8183..8381 CDD:240271
PTZ00449 <8430..8745 CDD:185628
PTZ00449 <8784..9125 CDD:185628
PTZ00449 <9028..9353 CDD:185628
PHA03307 9225..>9575 CDD:223039
PHA03307 9903..>10259 CDD:223039
PTZ00108 <10177..10451 CDD:240271
ank1bXP_021324740.2 None
Blue background indicates that the domain is not in the aligned region.

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