DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and Tnks2

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	NP_001157107.1	Gene:	Tnks2 / 74493	MGIID:	1921743	Length:	1166	Species:	Mus musculus

Alignment Length:	1022	Identity:	290/1022 - (28%)
Similarity:	430/1022 - (42%)	Gaps:	226/1022 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AARAGNLERVLEHLKNNIDINTSNANGLNA--LHLASKDGHIHVVSELLRRGAIVDSATKKGNTA 80
            |.|.|::||| :.|.....:|:.:..|..:  ||.|:..|...||..||:.||.|.:....|...
Mouse    31 ACRNGDVERV-KRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIP 94

  Fly    81 LHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFT 145
            ||.|...|..|||.|||:|.|..|.:....:|||:.||.:....|..:||.:||..::...||.|
Mouse    95 LHNACSFGHAEVVNLLLQHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRT 159

  Fly   146 ------PLAVAMQQG---------------HDKVVAVLLESDTR-----GKVRLPALHIAAKKDD 184
                  |.|.|:..|               .:|::|:|...:..     |:...| ||:||..:.
Mouse   160 ALDLADPSAKAVLTGDYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTP-LHLAAGYNR 223

  Fly   185 VKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWG 249
            ||...|||.:..:.....|....|||.|..||:..:..||::.||.||.......:|||.||...
Mouse   224 VKIVQLLLHHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKN 288

  Fly   250 KTNMVSLLLEKGG-----NIEAKTRDGLTP----------------------------------- 274
            :..:.||||..|.     |...|:...|.|
Mouse   289 RIEVCSLLLSYGADPTLLNCHNKSAIDLAPTAQLKERLSYEFKGHSLLQAAREADVTRIKKHLSL 353

  Fly   275 --------------LHCAARSGH---EQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARI 322
                          |||||.|.:   :|:.::||.:||..:.|||..|.|||:|::..|.|...:
Mouse   354 EMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANTNEKTKEFLTPLHVASENAHNDVVEV 418

  Fly   323 LLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVE 387
            ::.|.|.|:.:.....|:||.||||||::..:|||....|.|..:|.|||.|.:..:.     |:
Mouse   419 VVKHEAKVNALDSLGQTSLHRAAHCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN-----VQ 478

  Fly   388 LLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTV----------------RG 436
            .||:.|||:.          |..|..       .||:...:.||.||                |.
Mouse   479 QLLQEGASLG----------HSEADR-------QLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQ 526

  Fly   437 ETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKD 501
            .||||.||..|:..::..||::||.|.|:.:....|||.|...|:.::..||::|||.|:.....
Mouse   527 STPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLW 591

  Fly   502 MYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDA--- 563
            .:|.||.||.:|:.|:..:|:::||......:.|.|||.| .|.|...:..||....|.:||
Mouse   592 KFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLLRGDAALLDAAKK 655

  Fly   564 --------------------QGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIA 608
                                ||::. ||||:|..|||.:||..||:.||..:|..|.|..|||.|
Mouse   656 GCLARVKKLSSPDNVNCRDTQGRHS-TPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNA 719

  Fly   609 ARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHL 673
            |....:|:|..|::|.|..||..|..|||||.::|:|..::..||:.|.|......:.|.||:.|
Mouse   720 ASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784

  Fly   674 CAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLH 738
            .:.:|   |:.:|  ..|....|....|.|..::...|.          ||..||.:|...:|..
Mouse   785 VSADD---VSALL--TAAMPPSALPTCYKPQVLSGVRGP----------GATADALSSGPSSPSS 834

  Fly   739 QTAQQGHCHIVNLLLEHKANANAQTVNGQTPL-------------HIARKLGYISVLDSLKTITK 790
            .:|.....::.....|..|..::....|.|.|             ...|.||    |:.|..|.:
Mouse   835 LSAASSLDNLSGSFSELSAVVSSSAAEGATGLQRKEDSGIDFSITQFIRNLG----LEHLMDIFE 895

  Fly   791 EDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEG------------GEDNMLSDQ----PYRYL 839
            .::              :..:.:.|....:.:|.|            |.:.::|.|    |  ||
Mouse   896 REQ--------------ITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNP--YL 944

  Fly   840 TVDEMKSLGDDSLPIDVTRD--------ERMDSN-RMTQSAEYASGV 877
            |   :.:.|..::.||::.|        |.|.|. |..:...:|.||
Mouse   945 T---LNNSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGV 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	8/22 (36%)
		Ank_4	11..64	CDD:290365	15/47 (32%)
		ANK	38..163	CDD:238125	46/147 (31%)
		ANK repeat	43..74	CDD:293786	12/32 (38%)
		Ank_2	48..135	CDD:289560	34/86 (40%)
		ANK repeat	76..107	CDD:293786	14/30 (47%)
		ANK repeat	109..134	CDD:293786	8/24 (33%)
		Ank_4	110..163	CDD:290365	19/73 (26%)
		Ank_4	172..225	CDD:290365	18/52 (35%)
		ANK repeat	175..202	CDD:293786	9/26 (35%)
		ANK	199..324	CDD:238125	48/181 (27%)
		ANK repeat	204..235	CDD:293786	12/30 (40%)
		Ank_2	209..300	CDD:289560	36/147 (24%)
		ANK repeat	237..268	CDD:293786	11/35 (31%)
		ANK	266..390	CDD:238125	47/175 (27%)
		ANK repeat	270..300	CDD:293786	13/81 (16%)
		ANK repeat	303..367	CDD:293786	24/63 (38%)
		Ank_2	308..399	CDD:289560	33/90 (37%)
		ANK	364..489	CDD:238125	40/140 (29%)
		ANK repeat	369..400	CDD:293786	10/30 (33%)
		ANK repeat	402..433	CDD:293786	6/30 (20%)
		Ank_4	403..456	CDD:290365	16/68 (24%)
		ANK repeat	435..466	CDD:293786	14/30 (47%)
		Ank_2	440..530	CDD:289560	32/89 (36%)
		ANK	463..588	CDD:238125	46/147 (31%)
		ANK repeat	468..497	CDD:293786	11/28 (39%)
		ANK repeat	501..530	CDD:293786	10/28 (36%)
		Ank_2	506..597	CDD:289560	37/113 (33%)
		ANK	529..654	CDD:238125	52/147 (35%)
		ANK repeat	535..565	CDD:293786	12/52 (23%)
		ANK repeat	567..598	CDD:293786	15/30 (50%)
		Ank_2	572..661	CDD:289560	39/88 (44%)
		ANK repeat	600..630	CDD:293786	12/29 (41%)
		ANK repeat	633..662	CDD:293786	11/28 (39%)
		ANK	661..785	CDD:238125	28/136 (21%)
		ANK repeat	666..697	CDD:293786	8/30 (27%)
		Ank_2	672..762	CDD:289560	18/89 (20%)
		ANK repeat	699..730	CDD:293786	7/30 (23%)
		ANK repeat	732..762	CDD:293786	4/29 (14%)
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
Tnks2	NP_001157107.1	ANK 1	23..52		8/21 (38%)
		Ank_4	28..78	CDD:290365	15/47 (32%)
		ANK	50..164	CDD:238125	40/113 (35%)
		ANK 2	57..86		11/28 (39%)
		ANK repeat	60..88	CDD:293786	11/27 (41%)
		Ank_2	62..154	CDD:289560	35/91 (38%)
		ANK repeat	90..121	CDD:293786	14/30 (47%)
		ANK 3	90..119		13/28 (46%)
		ANK repeat	123..154	CDD:293786	10/30 (33%)
		ANK 4	123..152		10/28 (36%)
		ANK	203..317	CDD:238125	36/114 (32%)
		ANK 5	210..239		10/29 (34%)
		ANK repeat	213..241	CDD:293786	10/28 (36%)
		Ank_2	215..307	CDD:289560	32/91 (35%)
		ANK repeat	243..274	CDD:293786	12/30 (40%)
		ANK 6	243..272		11/28 (39%)
		ANK repeat	276..307	CDD:293786	10/30 (33%)
		ANK 7	276..305		10/28 (36%)
		ANK 8	363..395		11/31 (35%)
		ANK repeat	365..397	CDD:293786	11/31 (35%)
		Ank_2	368..461	CDD:289560	37/92 (40%)
		ANK	394..579	CDD:238125	66/206 (32%)
		ANK repeat	399..430	CDD:293786	10/30 (33%)
		ANK 9	399..428		10/28 (36%)
		ANK 10	432..461		13/28 (46%)
		ANK repeat	433..521	CDD:293786	33/109 (30%)
		Ank_2	437..556	CDD:289560	46/140 (33%)
		ANK 11	463..489		11/40 (28%)
		ANK	518..643	CDD:238125	42/125 (34%)
		ANK 12	525..554		13/28 (46%)
		ANK repeat	528..556	CDD:293786	13/27 (48%)
		Ank_2	530..622	CDD:289560	32/91 (35%)
		HIF1AN-binding. /evidence=ECO:0000250\|UniProtKB:Q9H2K2	545..553		4/7 (57%)
		ANK repeat	558..589	CDD:293786	11/30 (37%)
		ANK 13	558..587		11/28 (39%)
		ANK repeat	591..622	CDD:293786	10/30 (33%)
		ANK 14	591..620		10/28 (36%)
		ANK 15	624..652		10/28 (36%)
		ANK repeat	644..674	CDD:293786	3/29 (10%)
		ANK	671..787	CDD:238125	47/116 (41%)
		ANK 16	678..707		14/29 (48%)
		ANK repeat	681..709	CDD:293786	15/27 (56%)
		Ank_2	683..775	CDD:289560	39/91 (43%)
		ANK repeat	711..742	CDD:293786	13/30 (43%)
		ANK 17	711..740		11/28 (39%)
		ANK repeat	744..775	CDD:293786	11/30 (37%)
		ANK 18	744..773		11/28 (39%)
		SAM_tankyrase1,2	871..936	CDD:188923	10/82 (12%)
		SAM	877..933	CDD:197735	10/73 (14%)
		tankyrase_like	938..1160	CDD:238718	15/56 (27%)
		PARP	952..1155	CDD:279038	10/37 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810