DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and ankrd28

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	XP_031760399.1	Gene:	ankrd28 / 734050	XenbaseID:	XB-GENE-5857499	Length:	1113	Species:	Xenopus tropicalis

Alignment Length:	893	Identity:	269/893 - (30%)
Similarity:	395/893 - (44%)	Gaps:	142/893 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALH 82
            |.:|......|..|.:|  :|.|:..|..|||.|:..||:.:||.||.|||.:::..||...|:|
Frog   143 ANKAVKCAEALVPLLSN--VNVSDRAGRTALHHAAFSGHVEMVSLLLSRGANINAFDKKDRRAIH 205

  Fly    83 IASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPL 147
            .|:..|..||||||:.|.|.|..:.:..:|||:.||.....:|::.||..|.:.:.:...|.|||
Frog   206 WAAYMGHIEVVKLLVTHGAEVMCKDKKSYTPLHAAASSGMISVIKYLLDLGVDMNESNAYGNTPL 270

  Fly   148 AVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHI- 211
            .||...|.|.||                             ..|:|...|.:..::.||||||.
Frog   271 HVACYNGQDVVV-----------------------------NELIDCGANVNQVNERGFTPLHFA 306

  Fly   212 -ASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPL 275
             ||.:|...: .||:..|||||..:|...:|||:.|..|:.:...::::.|..|:.:.::|.|||
Frog   307 AASTHGALCL-ELLVCNGADVNIKSKDGKTPLHMTAIHGRFSRSQIIIQNGAEIDCEDKNGNTPL 370

  Fly   276 HCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTA 340
            |.|||.|||.:::.|:...|..|.:..:|:.|||:||.....|..|.||.....:|.......|.
Frog   371 HIAARYGHELLINTLITSRADTSKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTHDDFGRTC 435

  Fly   341 LHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLT 405
            ||.||..|::....|||...||.|.:...|.||||.|......:.:..|:..|||::...|.|.:
Frog   436 LHAAAAGGNLECLNLLLSTGADFNKKDKFGRTPLHYAAANCNYQCLFALVGSGASVNDLDERGCS 500

  Fly   406 PLHVAAFMG----CMNIVIYLLQHDASPDVPTVRG------------------------------ 436
            |||.||...    |:.   |||::||:|.:....|
Frog   501 PLHYAATSDTDGKCLE---YLLRNDANPGIRDKHGYNAVHYAAAYGHRLCLELIARETPLDVLME 562

  Fly   437 ----------ET-----PLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVM 486
                      ||     ||||||.......:.:|:::...:|.|....:|||.:|:..|:|:.|.
Frog   563 TSGTDMLNDAETRAPISPLHLAAYHGHHQALEVLVQSLLDLDVRNSTGRTPLDLAAFKGHVECVD 627

  Fly   487 LLLQHGAQVDATTKDMY---TALH---------------------------IAAKE------GQD 515
            :|:..||.:  ..||..   |.:|                           :.||:      |..
Frog   628 VLINQGASI--LVKDYVVKRTPIHSAEIQMVDSRNSVNKNNTELCNSAQKKVRAKDMPSAINGHS 690

  Fly   516 EVAAVLIENG---AALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACH 577
            |...:||.|.   ||:|.....|.|||.|:...||.:....||.|.|:|||:.|.|.|.||....
Frog   691 ECLRLLIGNADVQAAVDIHDGNGQTPLMLSVLNGHTECVYSLLNKGANVDAKDKWGRTALHRGAV 755

  Fly   578 YNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYG-------ALANAESKAGF 635
            ..:::....||:..|:.......|.||:|:||....:.:.:.||:..       |:|:   ..|:
Frog   756 TGHEECVEALLQHNANFLLRDCRGRTPIHLAAACGHIGVLSALLQTAISVDVVPAIAD---NHGY 817

  Fly   636 TPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEIL-EKNGANI-DMATK 698
            ||||.:...||.....||:|.: .......|..:|:|.....||...||:| :..|.:| :....
Frog   818 TPLHWACYNGHDACVELLLEQE-VFQKMEGNSFSPLHCAVINDNEGAAEMLIDTLGTSIVNSVDS 881

  Fly   699 AGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEH-KANANAQ 762
            .|.||||.|:.......::.||.:.|.|:|..|.|.|||...|:.|....|.:|:.. ||:...|
Frog   882 KGRTPLHAAAFTDHIECLQLLLSHNAQVNAVDSTGKTPLMMAAENGQTSAVEVLVSSAKADLTLQ 946

  Fly   763 TVNGQTPLHIARKLGY-ISVLDSLKTITKEDETAAAPSQAEEKYRVVA 809
            ..|..|.||:|...|: .|.|..|:.||..:...|..|..:....|.|
Frog   947 DKNKNTALHLACSKGHETSALLILEQITDRNLINATNSALQTPLHVAA 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	6/22 (27%)
		Ank_4	11..64	CDD:290365	16/45 (36%)
		ANK	38..163	CDD:238125	50/124 (40%)
		ANK repeat	43..74	CDD:293786	14/30 (47%)
		Ank_2	48..135	CDD:289560	36/86 (42%)
		ANK repeat	76..107	CDD:293786	14/30 (47%)
		ANK repeat	109..134	CDD:293786	8/24 (33%)
		Ank_4	110..163	CDD:290365	19/52 (37%)
		Ank_4	172..225	CDD:290365	13/54 (24%)
		ANK repeat	175..202	CDD:293786	3/26 (12%)
		ANK	199..324	CDD:238125	46/126 (37%)
		ANK repeat	204..235	CDD:293786	16/32 (50%)
		Ank_2	209..300	CDD:289560	34/92 (37%)
		ANK repeat	237..268	CDD:293786	7/30 (23%)
		ANK	266..390	CDD:238125	43/123 (35%)
		ANK repeat	270..300	CDD:293786	14/29 (48%)
		ANK repeat	303..367	CDD:293786	23/63 (37%)
		Ank_2	308..399	CDD:289560	31/90 (34%)
		ANK	364..489	CDD:238125	44/173 (25%)
		ANK repeat	369..400	CDD:293786	10/30 (33%)
		ANK repeat	402..433	CDD:293786	13/34 (38%)
		Ank_4	403..456	CDD:290365	22/101 (22%)
		ANK repeat	435..466	CDD:293786	11/75 (15%)
		Ank_2	440..530	CDD:289560	31/128 (24%)
		ANK	463..588	CDD:238125	45/163 (28%)
		ANK repeat	468..497	CDD:293786	10/28 (36%)
		ANK repeat	501..530	CDD:293786	12/67 (18%)
		Ank_2	506..597	CDD:289560	33/126 (26%)
		ANK	529..654	CDD:238125	41/131 (31%)
		ANK repeat	535..565	CDD:293786	14/29 (48%)
		ANK repeat	567..598	CDD:293786	7/30 (23%)
		Ank_2	572..661	CDD:289560	25/95 (26%)
		ANK repeat	600..630	CDD:293786	10/36 (28%)
		ANK repeat	633..662	CDD:293786	10/28 (36%)
		ANK	661..785	CDD:238125	41/127 (32%)
		ANK repeat	666..697	CDD:293786	10/32 (31%)
		Ank_2	672..762	CDD:289560	30/92 (33%)
		ANK repeat	699..730	CDD:293786	11/30 (37%)
		ANK repeat	732..762	CDD:293786	10/30 (33%)
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
ankrd28	XP_031760399.1	ANK repeat	38..65	CDD:293786
		PHA03095	49..>337	CDD:222980	75/225 (33%)
		ANK repeat	67..98	CDD:293786
		ANK repeat	103..131	CDD:293786
		ANK repeat	133..164	CDD:293786	6/22 (27%)
		ANK repeat	167..197	CDD:293786	14/29 (48%)
		ANK repeat	199..230	CDD:293786	14/30 (47%)
		ANK repeat	232..263	CDD:293786	9/30 (30%)
		PHA03095	246..>532	CDD:222980	102/318 (32%)
		ANK repeat	265..296	CDD:293786	13/59 (22%)
		ANK repeat	298..329	CDD:293786	16/31 (52%)
		ANK repeat	332..363	CDD:293786	7/30 (23%)
		ANK repeat	365..395	CDD:293786	14/29 (48%)
		ANK repeat	402..429	CDD:293786	10/26 (38%)
		Ank_2	416..>651	CDD:423045	66/239 (28%)
		ANK repeat	431..462	CDD:293786	12/30 (40%)
		ANK repeat	464..495	CDD:293786	10/30 (33%)
		ANK repeat	497..529	CDD:293786	13/34 (38%)
		ANK repeat	531..561	CDD:293786	1/29 (3%)
		ANK repeat	563..607	CDD:293786	10/43 (23%)
		ANK repeat	609..640	CDD:293786	10/32 (31%)
		PHA03095	694..>1023	CDD:222980	96/305 (31%)
		ANK repeat	712..743	CDD:293786	14/30 (47%)
		ANK repeat	745..776	CDD:293786	7/30 (23%)
		ANK repeat	882..913	CDD:293786	11/30 (37%)
		ANK repeat	915..947	CDD:293786	10/31 (32%)
		ANK repeat	949..1016	CDD:293786	15/46 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53364at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920