DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank2 and tnksb

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:XP_005171800.1 Gene:tnksb / 567533 ZFINID:ZDB-GENE-030131-4865 Length:1284 Species:Danio rerio


Alignment Length:1188 Identity:311/1188 - (26%)
Similarity:502/1188 - (42%) Gaps:227/1188 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 GAQGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNA--LHLASKDGHIHVVSELLRRGA 68
            ||.|.....| .|.|.|::.|| :.|.:::::|..:..|..:  ||.|:..|...||..||:.||
Zfish   120 GAGGAFRELF-EACRNGDVSRV-KRLVDSVNVNAKDMAGRKSTPLHFAAGFGRKDVVEHLLQTGA 182

  Fly    69 IVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNG 133
            .|.|....|...||.|...|..|||.|||...|..|.:....:|||:.||.:....|..:||.:|
Zfish   183 NVHSRDDGGLIPLHNACSFGHAEVVSLLLCSGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 247

  Fly   134 ANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNP 198
            |:.::...||.:.|.:|               |...|..|...:   |||::..|          
Zfish   248 ADPNIRNTDGKSALDLA---------------DPSAKTVLTGEY---KKDELLEA---------- 284

  Fly   199 DVTSKSG--------FTPLHIASHY--GNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNM 253
               ::||        .|||::..|.  |.::.:..::.             :|||:||.:.:..:
Zfish   285 ---ARSGNEEKLMALLTPLNVNCHASDGRKSTSQKMLS-------------TPLHLAAGYNRVRI 333

  Fly   254 VSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVD 318
            |.|||:.|.::.||.:.||.|||.|...||.:|.::||:.||.::|.......|||.||....|:
Zfish   334 VQLLLQYGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVE 398

  Fly   319 AARILLYHRAPVDEVTVDYLTALHVA-----------AHCGHVRVAKLLLDRNAD-----ANARA 367
            ...:||.|.|....:.....:|:.||           ...||   :.|...|.||     ..|:.
Zfish   399 VCSLLLSHGADPTLLNCHGKSAVDVAPTPELKERLTYEFKGH---SLLQAAREADMAKVKKTAQE 460

  Fly   368 LNGF-------TPLHIACKK---NRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYL 422
            :..|       :.||.|...   .|.:|.|||||.||:|....:..:||.||||..|..:::..|
Zfish   461 IISFKHPHSHDSALHCAVASPHPKRKQVTELLLRKGANIHEKNKDFMTPFHVAAERGHNDVLEVL 525

  Fly   423 LQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVML 487
            .:|.|..:.....|:|.||.||.|......|:||..||.....:.:..|    ||::||..:..:
Zfish   526 QKHGAKVNAADTLGQTALHRAALAGHIQTCRLLLSYGADPSIVSLQGFT----ASQMGNEAVQQI 586

  Fly   488 LLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLI--ENGAALDAATKKGFTPLHLTAKYGHIKV 550
            |.::   |.....|:...|..|||.|..:....|.  :|....|...:.. ||||..|.|..:.|
Zfish   587 LNEN---VPPRNSDVDYRLLEAAKAGDLDTVKQLCSPQNVNCRDLEGRHS-TPLHFAAGYNRVAV 647

  Fly   551 AQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMD 615
            .:.||...|||.|:.|.|:.|||.||.|.:.:||.||:..|||.:.......||||.||.|.:.:
Zfish   648 VEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYE 712

  Fly   616 IATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGL------------ 668
            |...||::||..:.:::.|...|.: .::|..:|.:|| ...||:...||.|.            
Zfish   713 ICKLLLKHGADPSKKNRDGNMALDM-VKDGDTDIQDLL-RGDAALLDAAKKGCLARVQKLCSPEN 775

  Fly   669 -----------TPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQN 722
                       ||:||.|..:|:.|||.|.::||:::...|.|..|||.|:.:|..::...|::.
Zfish   776 INCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKF 840

  Fly   723 GANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVL----- 782
            ...|:|.....:||||:.||:|...:..|||.|.||...:...|||.|.:|......::|     
Zfish   841 NTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGANPTMKNQEGQTALDLATADDIRALLMDAMP 905

  Fly   783 -DSLKTITKEDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEGGEDNM---LSDQPYRYLTVDE 843
             |:|.:..|...|..:.:       :::|.:......:.|    ..||:   |.|          
Zfish   906 PDALPSCFKPQATVLSAA-------LISPASTPSCLSAAS----SIDNLAGPLCD---------- 949

  Fly   844 MKSLGDDSLPID--VTRDERMDSNRMTQSAEYASGVPPTIGEEVIS---PHKTQVYGSSPKATVD 903
             .:.|..:.|.|  .:.|.:.....:.|..:..:.:...|.:.:.|   .|...:: ...:.|:|
Zfish   950 -GASGGAAGPADGASSTDRKEGDGALIQGNKLTAVLDMNISQFLKSLGLEHLRDIF-EREQITLD 1012

  Fly   904 GVYIANGSGHDEPPHVGRKLSWKSFLVSFLVDARGGAMRGCRH---SGVRMIIPSRSTCQPTRVT 965
               :....||:|...:|             ::|.|.     ||   .|:..::..:....|    
Zfish  1013 ---VLADMGHEELKEIG-------------INAYGH-----RHKLIKGIERLLGGQQGANP---- 1052

  Fly   966 CRYVKPQRTMHPPQLMEGEALASRVLELGPCSTKFIGPVVMEV----PHFASLRGKEREIIILRS 1026
              |:    |.|                   |:.:  |.|::::    ..|.|:..:.:..|....
Zfish  1053 --YL----TFH-------------------CTNQ--GTVLIDLAVDDKEFQSVEEEMQSTIREHR 1090

  Fly  1027 DNGE---TWREHTIDNSEEIIHDVLQQCF--EPEEIAQLEEQAGNHVCRFVTYDFPQYFAVVSRI 1086
            |.|.   .:..:.:...:::::..|::.:  ..:|||  :|...:|..|.:.:..|...|::.:.
Zfish  1091 DGGNAGGVFSRYNVIKIQKVVNKKLRERYTHRQKEIA--DENHNHHNERMLFHGSPFINAIIHKG 1153

  Fly  1087 RQEVHAIGPEGGMVSSTV 1104
            ..|.||.  .|||..:.:
Zfish  1154 FDERHAY--IGGMFGAGI 1169

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786 8/30 (27%)
Ank_4 11..64 CDD:290365 15/54 (28%)
ANK 38..163 CDD:238125 41/126 (33%)
ANK repeat 43..74 CDD:293786 13/32 (41%)
Ank_2 48..135 CDD:289560 34/86 (40%)
ANK repeat 76..107 CDD:293786 13/30 (43%)
ANK repeat 109..134 CDD:293786 8/24 (33%)
Ank_4 110..163 CDD:290365 14/52 (27%)
Ank_4 172..225 CDD:290365 12/62 (19%)
ANK repeat 175..202 CDD:293786 4/26 (15%)
ANK 199..324 CDD:238125 39/134 (29%)
ANK repeat 204..235 CDD:293786 7/40 (18%)
Ank_2 209..300 CDD:289560 28/92 (30%)
ANK repeat 237..268 CDD:293786 11/30 (37%)
ANK 266..390 CDD:238125 44/149 (30%)
ANK repeat 270..300 CDD:293786 13/29 (45%)
ANK repeat 303..367 CDD:293786 20/79 (25%)
Ank_2 308..399 CDD:289560 33/116 (28%)
ANK 364..489 CDD:238125 42/134 (31%)
ANK repeat 369..400 CDD:293786 14/40 (35%)
ANK repeat 402..433 CDD:293786 10/30 (33%)
Ank_4 403..456 CDD:290365 18/52 (35%)
ANK repeat 435..466 CDD:293786 12/30 (40%)
Ank_2 440..530 CDD:289560 25/91 (27%)
ANK 463..588 CDD:238125 40/126 (32%)
ANK repeat 468..497 CDD:293786 7/28 (25%)
ANK repeat 501..530 CDD:293786 8/30 (27%)
Ank_2 506..597 CDD:289560 36/92 (39%)
ANK 529..654 CDD:238125 46/124 (37%)
ANK repeat 535..565 CDD:293786 13/29 (45%)
ANK repeat 567..598 CDD:293786 14/30 (47%)
Ank_2 572..661 CDD:289560 32/88 (36%)
ANK repeat 600..630 CDD:293786 12/29 (41%)
ANK repeat 633..662 CDD:293786 8/28 (29%)
ANK 661..785 CDD:238125 45/152 (30%)
ANK repeat 666..697 CDD:293786 13/53 (25%)
Ank_2 672..762 CDD:289560 33/89 (37%)
ANK repeat 699..730 CDD:293786 9/30 (30%)
ANK repeat 732..762 CDD:293786 13/29 (45%)
ZU5 927..1030 CDD:128514 16/109 (15%)
Death_ank 1417..1497 CDD:260029
ER-remodelling 11936..>12013 CDD:258892
tnksbXP_005171800.1 Ank_4 128..178 CDD:290365 15/51 (29%)
ANK 150..264 CDD:238125 40/113 (35%)
ANK repeat 160..188 CDD:293786 12/27 (44%)
Ank_2 162..254 CDD:289560 35/91 (38%)
ANK repeat 190..221 CDD:293786 13/30 (43%)
ANK 218..404 CDD:238125 61/229 (27%)
ANK repeat 223..254 CDD:293786 10/30 (33%)
ANK repeat 320..348 CDD:293786 11/27 (41%)
Ank_2 322..414 CDD:289560 35/91 (38%)
ANK repeat 350..381 CDD:293786 14/30 (47%)
ANK repeat 383..414 CDD:293786 10/30 (33%)
ANK repeat 471..503 CDD:293786 13/31 (42%)
Ank_2 474..568 CDD:289560 35/93 (38%)
ANK 501..685 CDD:238125 62/191 (32%)
ANK repeat 505..536 CDD:293786 10/30 (33%)
ANK repeat 538..568 CDD:293786 12/29 (41%)
Ank_2 543..662 CDD:289560 39/126 (31%)
ANK 624..749 CDD:238125 45/126 (36%)
ANK repeat 634..662 CDD:293786 13/27 (48%)
Ank_2 636..728 CDD:289560 38/91 (42%)
ANK repeat 664..695 CDD:293786 14/30 (47%)
ANK repeat 697..728 CDD:293786 12/30 (40%)
ANK repeat 750..780 CDD:293786 5/29 (17%)
Ank_4 751..805 CDD:290365 14/53 (26%)
ANK 777..891 CDD:238125 39/113 (35%)
ANK repeat 784..815 CDD:293786 12/30 (40%)
Ank_2 789..881 CDD:289560 33/91 (36%)
ANK repeat 817..848 CDD:293786 9/30 (30%)
ANK repeat 850..881 CDD:293786 13/30 (43%)
SAM_tankyrase1,2 981..1046 CDD:188923 14/86 (16%)
SAM 987..1044 CDD:197735 14/78 (18%)
tankyrase_like 1048..1270 CDD:238718 27/157 (17%)
PARP 1062..1265 CDD:279038 22/112 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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