DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and caiap

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	NP_001020663.1	Gene:	caiap / 557416	ZFINID:	ZDB-GENE-041014-19	Length:	744	Species:	Danio rerio

Alignment Length:	683	Identity:	200/683 - (29%)
Similarity:	320/683 - (46%)	Gaps:	70/683 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVTENGAQGDGNTSFLRAARAGNLERVLEHLKNNI-------------DINTSNANGLNALHLAS 52
            |.|..|...:|    :|.||...:..:||..|..:             ..|..|...||...|.|
Zfish    94 MRTYVGGVNEG----IRDARRQLIGYLLEKDKQGLVKNSKPERIHPKSTANEPNNEPLNKQILKS 154

  Fly    53 KDGHIHVVSELLRRGAI-----------VDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQ 106
            :..|...:.|.:..|.:           |:|.....:|.||.|:..|:|.:|..||...|.::::
Zfish   155 ESNHHDAILEAISSGDLYLLQELTKELDVNSVLSSNDTLLHHAAEYGKEAIVYFLLRQGAKLDLK 219

  Fly   107 SQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRG-K 170
            .:.|.|.|:.|||..|.||...|...||:.....:...|||.:|.|.||:..|..|:..:.:. |
Zfish   220 DKEGRTALHRAAQRGHTAVAVALAKAGADIHATDQTSKTPLHLAAQNGHEGCVKALVHEEKKSLK 284

  Fly   171 VRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSA 235
            .:...||:||.:|:...|.:||.|....|.......|.||.|..:||:..|.:|::.||.|:...
Zfish   285 NQTTVLHMAAIEDNATLAEVLLRNGALVDAQDGQRKTALHHAVRHGNEKTAAVLLKAGAQVDSRI 349

  Fly   236 KHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAK 300
                  :..|.:..:.:::||.|:......::|... ..|..|.:...:.||..|:|.||.:::.
Zfish   350 ------VDAAFQLNRKSLLSLFLQHVHESMSQTEIN-AALFKAVQRNLDAVVAALIEHGADVNSC 407

  Fly   301 TKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANA 365
            .:.|..|:.:||:..:.:|.::|:..:|.:||...:.:::||:|...|.:::|::||.:..|.|.
Zfish   408 NELGYTPVLLAAELGNGEAFKVLVSKKAKLDERLPNQMSSLHLAVQSGSIQIAQILLHKGIDPNI 472

  Fly   366 RALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPD 430
            ......||||::...|:..::.||||.||.::..|:.|.||||:|:..|....|..||:..|...
Zfish   473 SGPKDQTPLHLSASHNQPAMMALLLRVGAQLNPVTQDGFTPLHLASQNGHTEAVAQLLEAKADVH 537

  Fly   431 VPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQV 495
            ....:|.|.||.||...:..||:.||..||..:|..||::||||:|:..|:...|..||...|:|
Zfish   538 AKDKQGRTALHWAAEQGEVAIIQSLLAAGAYSNASEREKKTPLHLAAAEGHTKAVSALLAGKAKV 602

  Fly   496 DATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGF--TPLHLTAKYGHIKVAQLLLQKE 558
            .|...|..:.||.||:.|::...:||:.:..:.:...|..:  |.|||.|::||..:..:||:.:
Zfish   603 GAKDMDGCSPLHYAARNGKERAGSVLLASSKSKNVDDKNVWRRTALHLAAEHGHEALVGILLENK 667

  Fly   559 ADVDAQGKNGVTPLHVAC---HYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTL 620
            |.::|...|..||||.||   |....| .|:....|...:..|.|.       .:||.:.:|
Zfish   668 AKINALDNNKDTPLHCACKTGHLGTVQ-RLINWTNGERANLQATNN-------VKKNALQVA--- 721

  Fly   621 LEYGALANAESKAGFTPLHLSSQEGHAEISNLL 653
                       :||.|       |.|..||.||
Zfish   722 -----------EAGDT-------EAHENISTLL 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	8/43 (19%)
		Ank_4	11..64	CDD:290365	15/65 (23%)
		ANK	38..163	CDD:238125	41/135 (30%)
		ANK repeat	43..74	CDD:293786	9/41 (22%)
		Ank_2	48..135	CDD:289560	28/97 (29%)
		ANK repeat	76..107	CDD:293786	10/30 (33%)
		ANK repeat	109..134	CDD:293786	10/24 (42%)
		Ank_4	110..163	CDD:290365	20/52 (38%)
		Ank_4	172..225	CDD:290365	17/52 (33%)
		ANK repeat	175..202	CDD:293786	10/26 (38%)
		ANK	199..324	CDD:238125	30/124 (24%)
		ANK repeat	204..235	CDD:293786	11/30 (37%)
		Ank_2	209..300	CDD:289560	23/90 (26%)
		ANK repeat	237..268	CDD:293786	4/30 (13%)
		ANK	266..390	CDD:238125	33/123 (27%)
		ANK repeat	270..300	CDD:293786	8/29 (28%)
		ANK repeat	303..367	CDD:293786	18/63 (29%)
		Ank_2	308..399	CDD:289560	27/90 (30%)
		ANK	364..489	CDD:238125	46/124 (37%)
		ANK repeat	369..400	CDD:293786	11/30 (37%)
		ANK repeat	402..433	CDD:293786	11/30 (37%)
		Ank_4	403..456	CDD:290365	19/52 (37%)
		ANK repeat	435..466	CDD:293786	13/30 (43%)
		Ank_2	440..530	CDD:289560	33/89 (37%)
		ANK	463..588	CDD:238125	45/129 (35%)
		ANK repeat	468..497	CDD:293786	12/28 (43%)
		ANK repeat	501..530	CDD:293786	8/28 (29%)
		Ank_2	506..597	CDD:289560	30/95 (32%)
		ANK	529..654	CDD:238125	37/130 (28%)
		ANK repeat	535..565	CDD:293786	11/31 (35%)
		ANK repeat	567..598	CDD:293786	11/33 (33%)
		Ank_2	572..661	CDD:289560	22/85 (26%)
		ANK repeat	600..630	CDD:293786	4/29 (14%)
		ANK repeat	633..662	CDD:293786	9/21 (43%)
		ANK	661..785	CDD:238125
		ANK repeat	666..697	CDD:293786
		Ank_2	672..762	CDD:289560
		ANK repeat	699..730	CDD:293786
		ANK repeat	732..762	CDD:293786
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
caiap	NP_001020663.1	CARD	15..94	CDD:260018	200/683 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..146		2/18 (11%)
		ANK 1. /evidence=ECO:0000255	157..185		4/27 (15%)
		ANK repeat	159..187	CDD:293786	4/27 (15%)
		PHA03095	160..>577	CDD:222980	126/423 (30%)
		ANK 2. /evidence=ECO:0000255	189..218		10/28 (36%)
		ANK repeat	191..220	CDD:293786	10/28 (36%)
		ANK repeat	222..253	CDD:293786	12/30 (40%)
		ANK 3. /evidence=ECO:0000255	222..251		12/28 (43%)
		ANK 4. /evidence=ECO:0000255	255..285		9/29 (31%)
		ANK 5. /evidence=ECO:0000255	287..314		9/26 (35%)
		ANK repeat	318..348	CDD:293786	11/29 (38%)
		ANK 6. /evidence=ECO:0000255	318..347		11/28 (39%)
		ANK 7. /evidence=ECO:0000255	377..406		8/29 (28%)
		ANK repeat	379..408	CDD:293786	8/29 (28%)
		ANK repeat	410..441	CDD:293786	9/30 (30%)
		ANK 8. /evidence=ECO:0000255	410..439		7/28 (25%)
		ANK 9. /evidence=ECO:0000255	443..472		8/28 (29%)
		ANK repeat	446..474	CDD:293786	9/27 (33%)
		PHA03095	463..>698	CDD:222980	84/235 (36%)
		ANK 10. /evidence=ECO:0000255	476..505		11/28 (39%)
		ANK repeat	478..507	CDD:293786	11/28 (39%)
		ANK repeat	509..540	CDD:293786	11/30 (37%)
		ANK 11. /evidence=ECO:0000255	509..538		11/28 (39%)
		ANK repeat	542..573	CDD:293786	13/30 (43%)
		ANK 12. /evidence=ECO:0000255	542..571		12/28 (43%)
		ANK repeat	575..606	CDD:293786	13/30 (43%)
		ANK 13. /evidence=ECO:0000255	575..604		12/28 (43%)
		ANK repeat	608..639	CDD:293786	8/30 (27%)
		ANK 14. /evidence=ECO:0000255	608..637		8/28 (29%)
		ANK repeat	641..674	CDD:293786	11/32 (34%)
		ANK 15. /evidence=ECO:0000255	643..672		10/28 (36%)
		ANK repeat	676..711	CDD:293786	12/35 (34%)
		ANK 16. /evidence=ECO:0000255	676..705		11/29 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593752
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1011028at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24123
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850