DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and PIDD1

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	XP_005253062.1	Gene:	PIDD1 / 55367	HGNCID:	16491	Length:	934	Species:	Homo sapiens

Alignment Length:	696	Identity:	152/696 - (21%)
Similarity:	268/696 - (38%)	Gaps:	173/696 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   898 PKATVDGVYI---ANGSGHDEP-----------PHVGRKLSWKSFLVSFLVDARGGAMR-GCRHS 947
            |...:|..::   .|..|...|           |.:.| |...|.|.||.|..:|.::. .|
Human   279 PPELLDAPFVRLQGNPLGEASPDAPSSPVAALIPEMPR-LFLTSDLDSFPVTPQGCSVTLAC--- 339

  Fly   948 GVRMIIPSRSTCQPTRVTCRYVKPQRTMHPPQLMEGEALASRVLELGPCSTKF---IGPVVMEVP 1009
            |||:..|:.:|..|..:..|.:.|:..:.|  |...:||.|.||||.|....|   :|..::..|
Human   340 GVRLQFPAGATATPITIRYRLLLPEPGLVP--LGPHDALLSHVLELQPHGVAFQQDVGLWLLFTP 402

  Fly  1010 HFASLRGKEREIIILRSDNGETWREHTIDNSEEIIHDVLQQCFEPEEIAQLEEQAGNHVCRFVTY 1074
            ..|.   :.||::: |:.|..:|.:             |:        ..|||:|...:......
Human   403 PQAR---RCREVVV-RTRNDNSWGD-------------LE--------TYLEEEAPQRLWAHCQV 442

  Fly  1075 DFPQYFAVVSRIRQEVHAIGPEGGMVSSTVVPQVQAVFPQGALTKKIKVGLQ-AQPVDPDLTAKL 1138
            ....:|.||||.......:.|||.::.|:..|.|:.:||.||..:..:|.:| .:....:|.|.|
Human   443 PHFSWFLVVSRPVSNACLVPPEGTLLCSSGHPGVKVIFPPGATEEPRRVSMQVVRMAGRELQALL 507

  Fly  1139 LGRGVAVSPIVTV-EPRRRKFHKAITLSMPAPKAHSQGMINQYSGNTPTLRLLCSITGGPSRAQW 1202
            .....||||::.: :.....|.:.:|:.:|.|..     |...|.:...|.||   ...|..|.|
Human   508 GEPEAAVSPLLCLSQSGPPSFLQPVTVQLPLPSG-----ITGLSLDRSRLHLL---YWAPPAATW 564

  Fly  1203 EDVTG--------------------STPLTFVND----CVSFTTTVSARFWL----MDCRNISDA 1239
            :|:|.                    |.|.:|::.    |.:..|..|.|:||    .:|  :...
Human   565 DDITAQVVLELTHLYARFQVTHFSWSVPPSFLSPPPPVCTALLTPSSPRYWLWYTTKNC--VGGL 627

  Fly  1240 TKMATELYKEVIHVPFIAKFVVFAKKVEPFEAKLRVFCMTDDREDKTLEK-HELYTEVAKSRDVE 1303
            .:.|.|..:  :|   ....:...::.:|.:..|:  |:..::.|.||.: .|.|.....|..||
Human   628 ARKAWERLR--LH---RVNLIALQRRRDPEQVLLQ--CLPRNKVDATLRRLLERYRGPEPSDTVE 685

  Fly  1304 VLEG----------------KPQYIEMAGNL-------------VPVTKSGDQLQVQFK---AFR 1336
            :.||                :|..:|  |.:             |.||.:.|:.....:   :|.
Human   686 MFEGEEFFAAFERGIDVDADRPDCVE--GRICFVFYSHLKNVKEVYVTTTLDREAQAVRGQVSFY 748

  Fly  1337 ENRLPFTVRVKDQ--------HADIVG-RTLFMKEPKVAKGEPPQQPICILNIVLPEAVIPDSTT 1392
            ...:|  |||.::        .||.:. .||.:|.|::...|.|::.   ..:.|....:.|:.|
Human   749 RGAVP--VRVPEEAEAARQRKGADALWMATLPIKLPRLRGSEGPRRG---AGLSLAPLNLGDAET 808

  Fly  1393 AFSDRVTSAYRTSMFSLSKHQNDHYIGDIRIVDLSNLLGKDWIQLAPEIGINGEEIDEIINQNTD 1457
            .|                       :....::.::..||.||..:|..:|::..|:..|.::..|
Human   809 GF-----------------------LTQSNLLSVAGRLGLDWPAVALHLGVSYREVQRIRHEFRD 850

  Fly  1458 SIARQAQSMIRLYKDK----PNYDILSLETALKNIGRDDIMKKCKS 1499
            .:..|.:.|:..:.::    |. .:..|..||:...|.|:.::.::
Human   851 DLDEQIRHMLFSWAERQAGQPG-AVGLLVQALEQSDRQDVAEEVRA 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786
		Ank_4	11..64	CDD:290365
		ANK	38..163	CDD:238125
		ANK repeat	43..74	CDD:293786
		Ank_2	48..135	CDD:289560
		ANK repeat	76..107	CDD:293786
		ANK repeat	109..134	CDD:293786
		Ank_4	110..163	CDD:290365
		Ank_4	172..225	CDD:290365
		ANK repeat	175..202	CDD:293786
		ANK	199..324	CDD:238125
		ANK repeat	204..235	CDD:293786
		Ank_2	209..300	CDD:289560
		ANK repeat	237..268	CDD:293786
		ANK	266..390	CDD:238125
		ANK repeat	270..300	CDD:293786
		ANK repeat	303..367	CDD:293786
		Ank_2	308..399	CDD:289560
		ANK	364..489	CDD:238125
		ANK repeat	369..400	CDD:293786
		ANK repeat	402..433	CDD:293786
		Ank_4	403..456	CDD:290365
		ANK repeat	435..466	CDD:293786
		Ank_2	440..530	CDD:289560
		ANK	463..588	CDD:238125
		ANK repeat	468..497	CDD:293786
		ANK repeat	501..530	CDD:293786
		Ank_2	506..597	CDD:289560
		ANK	529..654	CDD:238125
		ANK repeat	535..565	CDD:293786
		ANK repeat	567..598	CDD:293786
		Ank_2	572..661	CDD:289560
		ANK repeat	600..630	CDD:293786
		ANK repeat	633..662	CDD:293786
		ANK	661..785	CDD:238125
		ANK repeat	666..697	CDD:293786
		Ank_2	672..762	CDD:289560
		ANK repeat	699..730	CDD:293786
		ANK repeat	732..762	CDD:293786
		ZU5	927..1030	CDD:128514	33/106 (31%)
		Death_ank	1417..1497	CDD:260029	17/83 (20%)
		ER-remodelling	11936..>12013	CDD:258892
PIDD1	XP_005253062.1	leucine-rich repeat	39..63	CDD:275380
		leucine-rich repeat	64..91	CDD:275380
		LRR_RI	<117..>279	CDD:238064	152/696 (22%)
		LRR_8	126..183	CDD:290566
		leucine-rich repeat	127..152	CDD:275380
		leucine-rich repeat	153..172	CDD:275380
		leucine-rich repeat	173..195	CDD:275380
		LRR_8	194..252	CDD:290566
		leucine-rich repeat	196..218	CDD:275380
		leucine-rich repeat	219..241	CDD:275380
		LRR_8	240..295	CDD:290566	3/15 (20%)
		leucine-rich repeat	242..264	CDD:275380
		leucine-rich repeat	265..286	CDD:275380	2/6 (33%)
		ZU5	325..398	CDD:295340	25/77 (32%)
		Peptidase_S68	421..453	CDD:287439	9/52 (17%)
		ZU5	465..537	CDD:295340	19/71 (27%)
		Death_PIDD	812..897	CDD:260049	17/85 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810