DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and tnks2

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	NP_001017008.2	Gene:	tnks2 / 549762	XenbaseID:	XB-GENE-968819	Length:	1167	Species:	Xenopus tropicalis

Alignment Length:	1245	Identity:	331/1245 - (26%)
Similarity:	504/1245 - (40%)	Gaps:	255/1245 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AQGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNA--LHLASKDGHIHVVSELLRRGAI 69
            |.|:.......|.|.|::||| ..|.|..::|:.:..|..:  ||.|:..|...||..||:.||.
Frog    21 AAGEPARELFEACRNGDVERV-RKLVNADNVNSRDTAGRKSTPLHFAAGFGRKDVVEHLLQSGAN 84

  Fly    70 VDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGA 134
            |.:....|...||.|...|..|||.|||.|.|..|.:....:|||:.||.:....|..:||.:||
Frog    85 VHARDDGGLIPLHNACSFGHAEVVSLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGA 149

  Fly   135 NQSLATEDGFT------PLAVAMQQG---------------HDKVVAVLLESDTR-----GKVRL 173
            :.::...|..|      |.|.|:..|               .:|::|:|...:..     |:...
Frog   150 DPTIRNTDSRTALDLSDPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKST 214

  Fly   174 PALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHN 238
            | ||:||..:.||...|||.:..:.....|....|||.|..||:..:..||:::||.||......
Frog   215 P-LHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKRGASVNAMDLWQ 278

  Fly   239 ISPLHVAAKWGKTNMVSLLLEKGG-----NIEAKTRDGLTP------------------------ 274
            .:|||.||...:..:.||||..|.     |...|:...|.|
Frog   279 FTPLHEAASKNRVEVCSLLLSYGADPTMLNCHNKSAIDLAPTPQLKEMLSYEFKGHSLLQAAREA 343

  Fly   275 -------------------------LHCAARSGH---EQVVDMLLERGAPISAKTKNGLAPLHMA 311
                                     |||||.|.:   :||.::|..:||.:|.|||:.|.|||:|
Frog   344 DLTRVKKHLSLEIVNFKHPQTHDTALHCAASSPYPKRKQVCELLFRKGANVSEKTKDFLTPLHVA 408

  Fly   312 AQGEHVDAARILLYHRAPVDEVTVDYL--TALHVAAHCGHVRVAKLLLDRNADANARALNGFTPL 374
            :...|.|...:|:.|.|.|:  .:|.|  |:||.||||||::..:|||:...|.:..:|.|||.|
Frog   409 SDKAHNDIVEVLIKHEAKVN--ALDNLGQTSLHRAAHCGHLQTCRLLLNSGCDPSIVSLQGFTAL 471

  Fly   375 HIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTV----- 434
            .:..:.     |:.:|:.|...|.|....                 .||:...:.||.||
Frog   472 QMGNES-----VQQILQEGLPFSNTDADR-----------------QLLEAAKAGDVETVKKLCT 514

  Fly   435 -----------RGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLL 488
                       |..||||.||..|:..::..||::||.|.|:.:....|||.|...|:.::..||
Frog   515 SQSVNCRDIEGRQSTPLHFAAGYNRVAVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL 579

  Fly   489 LQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQL 553
            ::|||.::......:|.||.||.:|:.|:..:|:::||......:.|.|||.| .|.|...:..|
Frog   580 VKHGAVINVADLWKFTPLHEAAAKGKYEICKLLLQHGADSTKKNRDGNTPLDL-VKDGDTDIQDL 643

  Fly   554 LLQKEADVDAQGKNGV-------TPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARK 611
            |....|.:||..|..|       ||.:|.|                  ..|.....||||:||..
Frog   644 LRGDAALLDAAKKGCVSRVKKLCTPENVNC------------------RDTQGRHSTPLHLAAGY 690

  Fly   612 NQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQ 676
            |.:::|..||:.||..||:.|.|..|||.::..||.:::.|||::.|.||...|...||:|..||
Frog   691 NNLEVAEYLLQNGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQ 755

  Fly   677 EDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTA 741
            :....:..:|..:||:..:..:.|..||.:.:    |:.||.|| ..|...||.|..|.|
Frog   756 KGRTQLCALLLAHGADPTLKNQEGQAPLDLVT----ADDVRALL-TAAMPPAALSTFYKP----- 810

  Fly   742 QQGHCHIVNLLL-EHKANANAQTVNGQTPLHIARKLGYISVLDSLKTITKEDET-----AAAPSQ 800
                 .::|:.. ...|.|...:|...:|     .|...|.||:|.:...|..:     |...|.
Frog   811 -----QLINVSQPSATAVATLSSVPSSSP-----TLSAASSLDNLASGFSEATSVSSGGAEGASG 865

  Fly   801 AEEKYRVVAPEAMHESFMSDSEEEGGEDNMLSDQPYRYLTVDEMKSLGDDSLPIDVTRDERMDSN 865
            .::|..|...|.....|:.:.    |.::::.......:|:|.:..:|....       :.:..|
Frog   866 LDKKEEVPGVELSINQFLRNL----GLEHLIDIFEREQITLDVLIEMGHKEF-------KEIGIN 919

  Fly   866 RMTQSAEYASGVPPTIGEEVISPHKTQVYGSSPKATVDGVYIANGSGH---DEPPHVGRKLSWKS 927
            ......:...||     |.:||..    :|.:|..|::   .|| ||.   |..|.....||.:.
Frog   920 AYGHRHKIIKGV-----ERLISGQ----HGLNPYLTLN---TAN-SGTILIDLAPDDKEFLSVEE 971

  Fly   928 FLVSFLVDARGGAMRGCRHSGV---RMIIPSRSTCQPTRVTCRYVKPQRTM--------HPPQLM 981
            .:.|.:.:.|.|...|    ||   ..|:..:..|. .::..||...::.:        :...|.
Frog   972 EMQSTVREHRDGGHAG----GVFTKYNILKIQKVCN-KKLWERYTHRRKEVTEENHNHSNERMLF 1031

  Fly   982 EGEALASRVLELG-PCSTKFIGPVVMEVPHFASLRGKEREIIILRSDNGETWREHTIDNSEEIIH 1045
            .|....:.::..| .....:||.:.....:||....|..:.:.  ...|.|......|.|..|.|
Frog  1032 HGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVY--GIGGGTGCPVHKDRSCYICH 1094

  Fly  1046 DVLQQC----------FEPEEIAQLEEQAGNH------------VCRFVTY----DFPQYFAVVS 1084
            ..|..|          |...::|  ....|:|            :..:|.|    .:|:|.....
Frog  1095 RQLLFCRVTLGKSFLQFSAMKMA--HSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQ 1157

  Fly  1085 RIRQEVHAIG 1094
            .:|.||.|.|
Frog  1158 IMRPEVVAEG 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	9/30 (30%)
		Ank_4	11..64	CDD:290365	16/54 (30%)
		ANK	38..163	CDD:238125	45/147 (31%)
		ANK repeat	43..74	CDD:293786	12/32 (38%)
		Ank_2	48..135	CDD:289560	34/86 (40%)
		ANK repeat	76..107	CDD:293786	14/30 (47%)
		ANK repeat	109..134	CDD:293786	8/24 (33%)
		Ank_4	110..163	CDD:290365	18/73 (25%)
		Ank_4	172..225	CDD:290365	18/52 (35%)
		ANK repeat	175..202	CDD:293786	9/26 (35%)
		ANK	199..324	CDD:238125	49/181 (27%)
		ANK repeat	204..235	CDD:293786	12/30 (40%)
		Ank_2	209..300	CDD:289560	37/147 (25%)
		ANK repeat	237..268	CDD:293786	11/35 (31%)
		ANK	266..390	CDD:238125	50/177 (28%)
		ANK repeat	270..300	CDD:293786	14/81 (17%)
		ANK repeat	303..367	CDD:293786	26/65 (40%)
		Ank_2	308..399	CDD:289560	33/92 (36%)
		ANK	364..489	CDD:238125	36/140 (26%)
		ANK repeat	369..400	CDD:293786	8/30 (27%)
		ANK repeat	402..433	CDD:293786	4/30 (13%)
		Ank_4	403..456	CDD:290365	14/68 (21%)
		ANK repeat	435..466	CDD:293786	14/30 (47%)
		Ank_2	440..530	CDD:289560	31/89 (35%)
		ANK	463..588	CDD:238125	39/131 (30%)
		ANK repeat	468..497	CDD:293786	10/28 (36%)
		ANK repeat	501..530	CDD:293786	10/28 (36%)
		Ank_2	506..597	CDD:289560	27/97 (28%)
		ANK	529..654	CDD:238125	41/131 (31%)
		ANK repeat	535..565	CDD:293786	12/29 (41%)
		ANK repeat	567..598	CDD:293786	5/37 (14%)
		Ank_2	572..661	CDD:289560	28/88 (32%)
		ANK repeat	600..630	CDD:293786	13/29 (45%)
		ANK repeat	633..662	CDD:293786	11/28 (39%)
		ANK	661..785	CDD:238125	33/124 (27%)
		ANK repeat	666..697	CDD:293786	8/30 (27%)
		Ank_2	672..762	CDD:289560	23/90 (26%)
		ANK repeat	699..730	CDD:293786	10/30 (33%)
		ANK repeat	732..762	CDD:293786	5/30 (17%)
		ZU5	927..1030	CDD:128514	18/114 (16%)
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
tnks2	NP_001017008.2	PTZ00322	28..>114	CDD:140343	32/86 (37%)
		ANK repeat	61..89	CDD:293786	11/27 (41%)
		PHA02876	<74..>438	CDD:165207	107/366 (29%)
		ANK repeat	91..122	CDD:293786	14/30 (47%)
		ANK repeat	124..155	CDD:293786	10/30 (33%)
		ANK repeat	214..242	CDD:293786	10/28 (36%)
		ANK repeat	244..275	CDD:293786	12/30 (40%)
		ANK repeat	277..308	CDD:293786	10/30 (33%)
		ANKYR	310..>472	CDD:223738	48/163 (29%)
		ANK repeat	366..398	CDD:293786	12/31 (39%)
		ANK repeat	400..431	CDD:293786	11/32 (34%)
		ANK repeat	434..522	CDD:293786	29/109 (27%)
		PHA03095	495..>804	CDD:222980	105/349 (30%)
		ANK repeat	529..557	CDD:293786	13/27 (48%)
		ANK repeat	559..590	CDD:293786	10/30 (33%)
		ANK repeat	592..623	CDD:293786	10/30 (33%)
		ANK repeat	645..675	CDD:293786	9/47 (19%)
		ANK repeat	682..710	CDD:293786	14/27 (52%)
		ANK repeat	712..743	CDD:293786	12/30 (40%)
		ANK repeat	745..776	CDD:293786	8/30 (27%)
		SAM_tankyrase1,2	872..937	CDD:188923	12/80 (15%)
		tankyrase_like	940..1161	CDD:238718	45/233 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910