DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and ank2b

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	XP_021333148.1	Gene:	ank2b / 450043	ZFINID:	ZDB-GENE-041010-165	Length:	3634	Species:	Danio rerio

Alignment Length:	4143	Identity:	1369/4143 - (33%)
Similarity:	1995/4143 - (48%)	Gaps:	903/4143 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ENGAQGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGA 68
            |...:.|.||||||||||||:::|||:||..:||.|||.|||||||||:|:||:.:|.|||.||:
Zfish    39 ERRRKSDSNTSFLRAARAGNIDKVLEYLKGGVDIGTSNQNGLNALHLAAKEGHVDLVQELLGRGS 103

  Fly    69 IVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNG 133
            .||||||||||||||||||||.:|||:|.:..|::|.||||||||||||:||||..|||.||.||
Zfish   104 SVDSATKKGNTALHIASLAGQGDVVKILSKRGANINAQSQNGFTPLYMASQENHLDVVRYLLENG 168

  Fly   134 ANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNP 198
            .|||:||||||||||:|:||||::||::|||:||:||||||||||||:|||.|:|.|||.||||.
Zfish   169 GNQSIATEDGFTPLAIALQQGHNQVVSILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 233

  Fly   199 DVTS-----------KSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTN 252
            ||.|           ||||||||||:||||.|:|.||:.:||.|:::|::.|:|||||:|.|.||
Zfish   234 DVQSKMMVNRTTENGKSGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 298

  Fly   253 MVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHV 317
            ||.|||::|..|:||||||||||||||||||:..|::|||||||:.|:|||||:||||||||:||
Zfish   299 MVHLLLDRGAQIDAKTRDGLTPLHCAARSGHDTAVELLLERGAPMLARTKNGLSPLHMAAQGDHV 363

  Fly   318 DAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNR 382
            :..:.||.|:||||:||:||||||||||||||.||.|||||:.|:.|||||||||||||||||||
Zfish   364 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNR 428

  Fly   383 LKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARAN 447
            :||:|||:::||.|.|.|||||||:|||||||.:|||:.|||:.|||||..:||||.||:||||.
Zfish   429 VKVMELLIKYGAFIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVSNIRGETALHMAARAG 493

  Fly   448 QTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKE 512
            |.:::|.||||||.|||||||.|||||||||||..:||.|||||.|..||.|.:.||.|||||:|
Zfish   494 QMEVVRCLLRNGAMVDARAREDQTPLHIASRLGKTEIVQLLLQHMAHPDAATANGYTPLHIAARE 558

  Fly   513 GQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGK-NGVTPLHVAC 576
            |..:|..||:|.|||...||||||||||:.:|||.::||:||||:.|..|:.|| ||:||||||.
Zfish   559 GHLDVTTVLLEAGAAHSLATKKGFTPLHVASKYGSLEVAKLLLQRRAPPDSAGKQNGLTPLHVAA 623

  Fly   577 HYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLS 641
            ||:||:||||||:||||||||||||:|||||||:||||:||||||:|||..|.::|.|..|:||:
Zfish   624 HYDNQKVALLLLDKGASPHATAKNGYTPLHIAAKKNQMEIATTLLQYGAETNIQTKQGVMPIHLA 688

  Fly   642 SQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHV 706
            |||||:|::.||::..|.||...|:|||.:||.||||.|.|.|||.|.|||:|..||.|||||.|
Zfish   689 SQEGHSEMAALLLQRGAQVNVTTKSGLTSLHLAAQEDKVGVGEILVKQGANLDQQTKLGYTPLIV 753

  Fly   707 ASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLH 771
            |.|:|.|.||.|||::||:|:..|..|||||||.||||:.||:|:||::.|..||.||||.|.|.
Zfish   754 ACHYGNAKMVNFLLKSGASVNDKTKNGYTPLHQAAQQGNTHIINVLLQYGAKPNAITVNGNTALA 818

  Fly   772 IARKLGYISVLDSLKTITKEDETAAAPSQAEEKYRVVAPEAMHESF-MSDSE-----EEG----- 825
            |||:||||||:|:|:.:|:|..|..  :...||:::..||.|.|.. :||.|     ::|
Zfish   819 IARRLGYISVVDTLRVVTEEIVTTT--TTVTEKHKLNVPETMTEVLDVSDEEVRRLVDDGAMSDD 881

  Fly   826 -----GEDNMLSDQPYRYLTVDEMKSLGDDSLP---ID-------VTRDERMDSNRMTQSAEYAS 875
                 |:|.|..|.. .||..::::.|||||||   :|       .....|.||...:....|.
Zfish   882 SIDFEGDDTMTGDGG-EYLRAEDLRELGDDSLPGQYLDGMNYLRFSLEGGRSDSRLQSLDRSYT- 944

  Fly   876 GVPPT----------IGEEVISPHKTQVYG------SSPKATVDGVYIANG---SGHDEPPHVGR 921
               ||          |.|:||..::....|      |.....:|.:.:::.   |||..|.|...
Zfish   945 ---PTHQSYYSKHYGIMEDVIYSNQVSSLGRENEKDSWETENLDNIALSSSPAHSGHCSPCHDHD 1006

  Fly   922 KLSWKSFLVSFLVDARGGAMRGCRHSGVRMIIPSRSTCQPTRVTCRYVKPQR------------- 973
            .   .||||||:|||||||||||||:|:|:|||.|....|||||||.||..|
Zfish  1007 N---SSFLVSFMVDARGGAMRGCRHNGLRLIIPPRKCSAPTRVTCRLVKRHRLATMPPMVEGDGL 1068

  Fly   974 ----------------TMH----PPQLMEGEALASRVLELGPCSTKFIGPVVMEVPHFASLRGKE 1018
                            .:|    ||.|.|||:|.||:|:|||..|||:|||::|:||||:|||||
Zfish  1069 ASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKE 1133

  Fly  1019 REIIILRSDNGETWREHTIDNSEEIIHDVLQQCFE----PEEIAQLEEQAGNHVCRFVTYDFPQY 1079
            ||::||||:.||:|:||..:.:||.::.||....|    |||:.:      ..:||.:|.|||||
Zfish  1134 RELVILRSETGESWKEHHCEYTEEELNQVLNGMDERLDPPEELEK------KRICRIITRDFPQY 1192

  Fly  1080 FAVVSRIRQEVHAIGPEGGMVSSTVVPQVQAVFPQGALTKKIKVGLQAQPVDPDLTAKLLGRGVA 1144
            |||||||:|:.:.||||||::||||||:||||||:|||||:|:||||.||:..|:...:||....
Zfish  1193 FAVVSRIKQDSNLIGPEGGVLSSTVVPEVQAVFPEGALTKRIRVGLQTQPMSVDVVRNMLGNKAT 1257

  Fly  1145 VSPIVTVEPRRRKFHKAITLSMPAPKAHSQGMINQY-SGNTPTLRLLCSITGGPSRAQWEDVTGS 1208
            .|||||:|||||||||.||:::|.||:.:...:..: .|.|||||||||||||.:.|||||:||:
Zfish  1258 FSPIVTLEPRRRKFHKPITMTIPVPKSSADPALGSFGGGETPTLRLLCSITGGTTPAQWEDITGT 1322

  Fly  1209 TPLTFVNDCVSFTTTVSARFWLMDCRNISDATKMATELYKEVIHVPFIAKFVVFAKKVEPFEAKL 1273
            |||||.||||||||.|||||||:|||.:.::...||.:|:|:|.||::||||:|||..:|.||:|
Zfish  1323 TPLTFTNDCVSFTTNVSARFWLIDCRQVQESVNFATLMYREIICVPYMAKFVIFAKTHDPIEARL 1387

  Fly  1274 RVFCMTDDREDKTLEKHELYTEVAKSRDVEVLEGKPQYIEMAGNLVPVTKSGDQLQVQFKAFREN 1338
            |.||||||:.|||||:.|.::|||:|||||||||||.|::..|||||:||||......|.||:||
Zfish  1388 RCFCMTDDKMDKTLEQQENFSEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHVFSFYAFKEN 1452

  Fly  1339 RLPFTVRVKDQHADIVGRTLFMKEPK----VAKGEPPQQPICILNIVLPEAVIPDSTTAFSDRVT 1399
            ||...::::|...:..||..|.|||:    ::.|     .:|.|||.||.......:....|..|
Zfish  1453 RLALFIKIRDNTQEPCGRLSFTKEPRSFRTLSHG-----AVCNLNISLPAYSKESDSDQEPDEET 1512

  Fly  1400 SAYRTSMFSLSKHQND-----------HYIGDIRIVDLSNLLG------KDWIQLAPEIGINGEE 1447
            |  ||    |.|:.:|           |.|.|...:...:||.      :|.|::...:..:..|
Zfish  1513 S--RT----LGKYDDDTETTETSILKTHLIRDSPALASPDLLSDVSEMKQDLIKMTAILTTDSSE 1571

  Fly  1448 -----IDEIINQNTDSIARQAQSMIRLYKDKPNYDILSLETALKNIGRDDIMKKCKSGRLSHSR- 1506
                 ..:.:.:..:.::.:...::...|:       .|| .:..|.|....:|.:|.:..|.|
Zfish  1572 KAGPMQGDYLGKGVEEVSAEPFEIMEKVKE-------DLE-KVSEILRSGTCEKEESAKTEHRRY 1628

  Fly  1507 ------------EFDEADLMKNSESVEEL-----VRRESKRIQQINEREEVKYSAEEKEVEESES 1554
                        |.:||.:|...||.|.|     |.|.|:|.:...||..:...    ||:|...
Zfish  1629 RKDEEWVLLTESEIEEAKMMAAFESQEALLKEVRVNRGSQRPKGARERSGIPIG----EVKEYLL 1689

  Fly  1555 DEEAAKRTVAERR-EKIVKRLSIERSIPASTQKKEITREITEIKRKSLIEDKKAHHESEILMQLP 1618
            |..|::.|.:::| .::|.|....:.:|                  ::.:|.|||
Zfish  1690 DAPASQETSSQQRFTEVVLRRGGRKIVP------------------TMAKDTKAH---------- 1726

  Fly  1619 ADNVIIKTTTVPDQVIKMKMGKMDSTEVSKSEFDKELTHKFKTSGRSSEEE-------DQPSYP- 1675
                   ||.:...|  .:.|....|:.::|...|| ....|::|::|||:       ||...|
Zfish  1727 -------TTEIKKPV--RRKGPQGHTDETQSISTKE-NIASKSAGKASEEDAFLPVPGDQKKSPV 1781

  Fly  1676 ----DQT--DKIVQDISAAEKKEKDGVTFSRVTTITRQ--EARDITEDFLEIEKRSQLPATSTTA 1732
                ::|  ..|.:.:.|.:||.::.....:..|..:.  ::.:.....|:.:|.:.|..||
Zfish  1782 SPVVEETPIGPIKEKVKALQKKVEEEQKGHKKQTSQKPPFKSTEAKTSVLKDQKTTGLKKTS--- 1843

  Fly  1733 TVHEKFVEEIKEKTSPLASVPQETVKEVQQVISEVTEIASKKVENIISSFESSKSVDATTV---- 1793
             :.:|.......||.|.......:|:|:.:.. :..:..||:...:......||:...|.:
Zfish  1844 -LPQKQSSSKSPKTEPERLEETMSVRELMRAF-QTGQDPSKRKSGLFEHKGPSKTEHTTMIKSEA 1906

  Fly  1794 -------LPTQPSVE-STKVSETIKNLEDAKAV--SAEQVKTVHV-------------VESSSIE 1835
                   ||...|.| |..||..:::.|:.:..  .|::.:..||             |||:..:
Zfish  1907 KTTNSQCLPHSSSREVSLDVSRPVEHHEEKEVFDKDAKENQKSHVCKQERSGEGLVFGVESAGQQ 1971

  Fly  1836 ETIAEFEAKKVKYDFHGGEPKTQIPKFTRKPSDDSMKPTAAPRATVESETESV-LETKAEKPISK 1899
            .::.                 |.|.:...|.:.|.:........|....::|: ||...:.|
Zfish  1972 SSMT-----------------TAIAQNVSKHASDLLPDNGTENGTFNDSSDSIKLEALVDSP--- 2016

  Fly  1900 IPVKTIPTEAQKVSEVDARKITQDFLQGEKLAAEPKPSPAASKIPKVEPRKSVDKQVDRESKILD 1964
                     :..::||:|...:::..:.|.:|..|:.||.:         .|:..|......||.
Zfish  2017 ---------SASLAEVEAPLSSEESCKHEGMAETPETSPES---------LSLSPQQKASQSILA 2063

  Fly  1965 DVVASTATIMTAGLGDEQLKDQLVDHSEIIAKSETVAEKVTELLDTFH-----KIEEKVTKSEKT 2024
            ....|||....|       |...|..| ..|:.:|..|:.:|.  |.|     |..::.||||..
Zfish  2064 KASNSTADTHKA-------KTSKVSVS-FSAEMKTKIEQASEA--TVHHPALSKAVDEPTKSESM 2118

  Fly  2025 ------------SEISSKVEELVKIEEKPLSQVQPKEDKVAEKVAEVIETFHKIEEKI------T 2071
                        .|.:...:::|.|..|     ..|..|:.::.:|.:|:|...:|..      |
Zfish  2119 CIPHRKKGVNFGGEQTFVDKDIVSISTK-----SSKSRKLTKRPSETLESFLSDDESCDGQPTPT 2178

  Fly  2072 TADA---RELTRDFLSMEQQNQLPSMPQAAEKPLESSLTSTSASEPESIVTVKPSPPASKIPVVE 2133
            .||:   |..|:|...:    .||...|.:|       |.:..::....::.|.|...|  |::|
Zfish  2179 FADSLTLRAATQDHGGL----VLPLRHQDSE-------TLSPVADDSFNISHKDSLEGS--PLME 2230

  Fly  2134 PRKIVFDESTKPLIEPEPVK------TTEKKPLNERQLTADFLSMEQQTQLVSEPAKSLVEEVMK 2192
            ...   ...|...|||.|.|      :.|..|:            |.::.|...|.
Zfish  2231 DNS---SHKTPDSIEPSPTKESPCCDSLENSPI------------EMKSNLAFPPT--------- 2271

  Fly  2193 SAEQMVEQPKQQKSLNERQLTEDFLLMEQQTQLPSDIVKPTDKLIDGIESAAPVGDEASPFHTPK 2257
                 ||||         .:|...|...:..|:|.|.::  ::::.  |..|.|.|::....:..
Zfish  2272 -----VEQP---------SVTTGPLTSSKAPQIPPDSLR--NRMLK--EQEANVDDDSCEQASLM 2318

  Fly  2258 LTTSVVTQEPQQLASEYDSDTFGKQATIPLGDSKIDQGLIAP--VSMEPRKSLTDAEF-CKSVGE 2319
            .::......|...:||..|.....|...|:       .||.|  .|:.|.:::.|.|. |.....
Zfish  2319 TSSGKSPLSPDTPSSEEVSYEVNPQPPDPM-------VLIVPFKASVIPEETVEDDELKCDLTQR 2376

  Fly  2320 TITKKMSVGVIEISDELKKIESEIPHSQTPPPTPSDNKTDKQNEEPELISLERDYLADTVTTLHT 2384
            ..|.:         :|:.|:.::|...........|.:..:::.|.....:..|...:.:|..
Zfish  2377 KFTPE---------EEMFKMAAKIKTFDEMEQDAKDKRDSRKDSEASQTLVVSDIGQEIITLF-- 2430

  Fly  2385 TTESTLERVSAITKIEHFSVHNVKSETFTRTDEPDKLLHSV-----VAPP--------------- 2429
                     ..::|.|..||.:|   .|..:.:..::..||     |.||
Zfish  2431 ---------GLVSKHETSSVDDV---GFIESKQASEIARSVEPIIKVQPPSPFPAGIHKSPQTAE 2483

  Fly  2430 DIQKLYSQDTTSFTEMSTSSQTPKMTTTTTMTAQIDRTKVDLTIPGQDQQKQKDLKEQSAVVVDA 2494
            |||:..:....|..|  ::.:.|:..|...            ||....|:...:...|..|..:.
Zfish  2484 DIQQTMAHSAASSDE--SAMRRPQSVTEKH------------TIKPHPQESHSEKFNQECVKSEL 2534

  Fly  2495 KAETEKTASDR---------EYLEQIMGCGDVRRKIMRLESSCSTE------SLESVGKSSTVTP 2544
             ||..||||.|         |..||.:    .::||...|...|.|      :.::|.|.::...
Zfish  2535 -AELNKTASSRSNLAANITDEQKEQSL----AKQKINESEEIYSHEMQNQAANFQNVDKLASQEE 2594

  Fly  2545 KYIGDNV--PVVREVVQSMEDKICSTV-VSAIPFTVQKRKP--------HDDDKEPNIVELEKQI 2598
            :.:.|.:  ..:|....|.:|...|:: :.::|..:.:.|.        :||.:|.:..|
Zfish  2595 RNVTDEIKGDYMRHAGTSYDDSCSSSLNIDSMPVIIGQNKETFKPEICIYDDTEEDDGEE----- 2654

  Fly  2599 LTPADLALEKIFKCEPPSE----VVKISPIEAMSLGLKEIDEEVCEKVCEKRKSFVVAEDLCETE 2659
                          |||..    |...:..::.: .::|.||....:|.|:             |
Zfish  2655 --------------EPPKTESRGVTAKAETDSWN-SMREDDEAFAARVKEE-------------E 2691

  Fly  2660 KTLTEQVIDLNRQ---VDQVPARVFTETIERHLDLEDRDVIEALPKVREVVQDIERKYPAASLEA 2721
            :.:...|:|.:.|   .|..|||..||              :..|        ...:.|....|.
Zfish  2692 QKILGLVVDRHSQGATPDTTPARTPTE--------------DGTP--------TSEQNPFLFQEG 2734

  Fly  2722 KPFSPRKRVTPDRKVDVS--SLEQQILTDADL---ILDGLGSKCVPEQKVQSPIFSSNKASSSTE 2781
            |.|    .:|....:|::  |.|::......:   |::|:..:            ..|::..::.
Zfish  2735 KLF----EMTRSGAIDMTKRSYEEEGFAFYQIEHPIMEGVAEE------------GGNESGGASG 2783

  Fly  2782 NLEDICEKKCSKRTISDMTKVFERQEDPTTMPSIKDVKSTTAKFLESESGKFAI-TESIQHFNAK 2845
            :.|.  |..|:   :|...|..|.::.|.....: .|:|.|||..:....|..| |:|
Zfish  2784 DAEK--EVGCN---LSLQIKAEEEEDQPKVAADL-SVRSATAKQSDLSKPKTPIKTDS------- 2835

  Fly  2846 GSINKEVAGIEKGQIRFLKDCDTQEFPIETNLDTKLVEFPKITHTLERLHSISKTDIADTKKVVH 2910
                      ||||                .:..| ||. |....:...|.||.:..:||  |:.
Zfish  2836 ----------EKGQ----------------GVSEK-VEI-KSDKVISEGHLISDSGSSDT--VIA 2870

  Fly  2911 ESSEFKSKLDKLVHKTEQTDNQNPDKFKFPTQDNFDELQTQKSLTSELVTMTDSSEYKFPPEGKS 2975
            ......|.:.:.||..::.::                              :|||     ||.:.
Zfish  2871 SIQTAVSTVTRSVHSQQEQES------------------------------SDSS-----PEDQH 2900

  Fly  2976 ILGKEPIESESDEELDNLNKICKLQLLSKIEQSSFIDTTEIAN-----TEKREITKFPT-TNDSH 3034
            .:.::|...|..|....|.        |||..::...||...|     .|::..::.|. .|...
Zfish  2901 SVIEQPKTPEKKESHGKLG--------SKIHTAASPSTTSKKNMSSSKEEEKPKSRIPVKANSLR 2957

  Fly  3035 SDLF-----SKSRATLKTQSGEKTHCTHFTETISDKNYNSFSDTSFLLNSVTASADKSPLHPEEK 3094
            |:|.     .||:..:|.||..|                |.:||..|:.::|.|:........:.
Zfish  2958 SELLEPAKDKKSKLPIKPQSRRK----------------SDTDTGPLIPTITKSSKAKSFCESDS 3006

  Fly  3095 TKSPEKKDEKVLAQPDDNFKSVIETDKPSPKEYSDEIEIP---KPLDKPI--SHPTSLVTGVTFG 3154
            :|.|.|||:......|     :..|.|..|.      .:|   || .:||  |.|.....|
Zfish  3007 SKKPAKKDQNRPTSTD-----LSSTTKTLPS------RLPVRGKP-GQPIQTSTPAKQKKG---- 3055

  Fly  3155 GDKSPLHPEEKPKSPVKIDEEVLAKPGGSSKSV--VETDKPSPKEYSDDETEDEIDFPKPQDKPF 3217
                  .|....|.||...||:..:.....:|:  .|.||......||||: ..||....:::||
Zfish  3056 ------RPTHTNKEPVVFFEEISQEAAKVVESLAQAEKDKQEAAVLSDDES-STIDVSVIENEPF 3113

  Fly  3218 KEA----------------TPSVTPVSTIPDVKAIDFVSFKAEECSTTIQTNIKLASTSLTTKDT 3266
            .:.                .|..|.:..||..|....|..:.|  :...::.:.:.:..|....:
Zfish  3114 LDMKMPFPEDPLVIRPRWDNPVETQMERIPADKVRSQVDPQDE--ADRKESRLAVIANHLGFSWS 3176

  Fly  3267 KIVQPID----SLSNLKDDKFPTSVGDKAKSPRESVKPNLKEYSDKEEKPDSHPVSLVTSVTGSG 3327
            ::.:.::    .::.::::. |.|:.|::.:       .::.:.::|.|..|.. ||:.::|...
Zfish  3177 ELARELEFSDVQINQIRNEN-PNSLQDQSHA-------LIRLWKEREGKNASEN-SLMKTLTKIN 3232

  Fly  3328 DKSPLHPEEKPKSPEKKDEKIL-AKPDDSSKSVVKTDKPSPKEYSD--DEIEDEIEIPKPLDK-P 3388
            ....:|..|         .||: :..|.||.:..:.::....::|:  ..::::::.|:...: .
Zfish  3233 RMDIVHLIE---------TKIIQSSQDHSSHTYAEIEQTISLDHSEGFSALQEDMDSPRSGRRAD 3288

  Fly  3389 ISHPTSLVTSVTGSGDKSPLHPEEKPKSPEKKDEKVLAKPDDSSKSVVKTDKPSPKEYSDDETED 3453
            :|...|.:..|..|.:...|:......|     :|.|  ||..:.|||..|    ..:|.:....
Zfish  3289 VSQRRSELVPVVASIEDLSLNASSLGDS-----QKEL--PDKVTSSVVVGD----STHSFEMVGL 3342

  Fly  3454 EIEIPKPLDKPISHPTSLVTGVTFGGDKSPLHPEEKLKSPEKKDEKVLAKPDDSSKSVVKTDKPS 3518
            ..:.|..:.:.|:....|::      |.|    ||::.:......:|:.:.||..:.       .
Zfish  3343 RQQFPGTIKQEIAEELGLLS------DSS----EEEVLTTRVVRRRVVIQGDDMPEI-------P 3390

  Fly  3519 PKEYSDDETEDEI--EIPKPLDKPISHPTSLVTGVTFGGDKSPLHPEEKLKSPEKKDEKVLAKPD 3581
            |:..::::..||.  .:.|.:.:.:........||.        ..|..|:.|::  |.|.....
Zfish  3391 PQTVTEEQYTDEYGNMVVKKITRKVIRKYVSADGVE--------REEVMLEGPQQ--EAVTVDEA 3445

  Fly  3582 DSSKSVVKTDKPSPKEYSDDETEDEIEIPKPLDKPISHPTSLVTGVTFGGDKSPLHPEEKPKSPE 3646
            ||...|||.   :......|:|  |:...:||              ::.|..|... ||:|....
Zfish  3446 DSFSKVVKR---TVVRSGGDQT--EVTFSEPL--------------SYAGATSSKF-EEEPVQGR 3490

  Fly  3647 K-------------KDEKVLAKPDGSSKSVVKTDKPSPKEYSDDETEDEIEIPKPLDKP-ISHPT 3697
            |             :.||::..|..||      |.||.|    |:.|..:...:..:|. :.|
Zfish  3491 KVSKVVKTMVVQGDRMEKLIGDPSLSS------DLPSAK----DDFEKALSYVEGFEKVLLPH-- 3543

  Fly  3698 SLVTGVTFGGDGSPLHREEKPKSPEKKDEKVLAKPDDSSKSVVKTDKPSPKEYSDDETEDEIEIP 3762
             ||...|...|||.:.|....|:..:|            ::|||..:  .|:...:..||..|..
Zfish  3544 -LVEKETVKEDGSVVRRTRMHKTRTQK------------RTVVKDGE--AKQTHLERLEDTAESL 3593

  Fly  3763 KPLD-------------KPISHPTSLVTGVTYGGDGSPLHPEEKPKSP 3797
            :|.|             .|..||              |...::||:.|
Zfish  3594 RPDDLQQHLHQLLQRYCTPEPHP--------------PAGQQDKPQPP 3627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	21/30 (70%)
		Ank_4	11..64	CDD:290365	36/52 (69%)
		ANK	38..163	CDD:238125	90/124 (73%)
		ANK repeat	43..74	CDD:293786	21/30 (70%)
		Ank_2	48..135	CDD:289560	62/86 (72%)
		ANK repeat	76..107	CDD:293786	20/30 (67%)
		ANK repeat	109..134	CDD:293786	19/24 (79%)
		Ank_4	110..163	CDD:290365	39/52 (75%)
		Ank_4	172..225	CDD:290365	41/63 (65%)
		ANK repeat	175..202	CDD:293786	20/26 (77%)
		ANK	199..324	CDD:238125	84/135 (62%)
		ANK repeat	204..235	CDD:293786	20/30 (67%)
		Ank_2	209..300	CDD:289560	59/90 (66%)
		ANK repeat	237..268	CDD:293786	18/30 (60%)
		ANK	266..390	CDD:238125	96/123 (78%)
		ANK repeat	270..300	CDD:293786	22/29 (76%)
		ANK repeat	303..367	CDD:293786	46/63 (73%)
		Ank_2	308..399	CDD:289560	67/90 (74%)
		ANK	364..489	CDD:238125	92/124 (74%)
		ANK repeat	369..400	CDD:293786	23/30 (77%)
		ANK repeat	402..433	CDD:293786	23/30 (77%)
		Ank_4	403..456	CDD:290365	34/52 (65%)
		ANK repeat	435..466	CDD:293786	21/30 (70%)
		Ank_2	440..530	CDD:289560	59/89 (66%)
		ANK	463..588	CDD:238125	83/125 (66%)
		ANK repeat	468..497	CDD:293786	20/28 (71%)
		ANK repeat	501..530	CDD:293786	16/28 (57%)
		Ank_2	506..597	CDD:289560	61/91 (67%)
		ANK	529..654	CDD:238125	86/125 (69%)
		ANK repeat	535..565	CDD:293786	17/29 (59%)
		ANK repeat	567..598	CDD:293786	25/30 (83%)
		Ank_2	572..661	CDD:289560	61/88 (69%)
		ANK repeat	600..630	CDD:293786	23/29 (79%)
		ANK repeat	633..662	CDD:293786	14/28 (50%)
		ANK	661..785	CDD:238125	77/123 (63%)
		ANK repeat	666..697	CDD:293786	19/30 (63%)
		Ank_2	672..762	CDD:289560	55/89 (62%)
		ANK repeat	699..730	CDD:293786	18/30 (60%)
		ANK repeat	732..762	CDD:293786	18/29 (62%)
		ZU5	927..1030	CDD:128514	71/135 (53%)
		Death_ank	1417..1497	CDD:260029	12/90 (13%)
		ER-remodelling	11936..>12013	CDD:258892
ank2b	XP_021333148.1	ANK repeat	45..76	CDD:293786	21/30 (70%)
		Ank_4	47..99	CDD:316185	36/51 (71%)
		ANK	76..198	CDD:238125	88/121 (73%)
		ANK repeat	78..109	CDD:293786	21/30 (70%)
		ANK repeat	111..142	CDD:293786	20/30 (67%)
		ANK repeat	144..173	CDD:293786	22/28 (79%)
		Ank_4	207..271	CDD:316185	41/63 (65%)
		ANK repeat	210..237	CDD:293786	20/26 (77%)
		ANK	249..370	CDD:238125	81/120 (68%)
		ANK repeat	250..281	CDD:293786	20/30 (67%)
		ANK repeat	283..314	CDD:293786	18/30 (60%)
		ANK	311..436	CDD:238125	96/124 (77%)
		ANK repeat	316..346	CDD:293786	22/29 (76%)
		ANK repeat	349..380	CDD:293786	20/30 (67%)
		ANK repeat	382..412	CDD:293786	23/29 (79%)
		ANK repeat	415..446	CDD:293786	23/30 (77%)
		Ank_4	418..469	CDD:316185	37/50 (74%)
		ANK repeat	448..479	CDD:293786	23/30 (77%)
		ANK	476..601	CDD:238125	81/124 (65%)
		ANK repeat	481..512	CDD:293786	21/30 (70%)
		ANK repeat	514..545	CDD:293786	22/30 (73%)
		ANK repeat	547..572	CDD:293786	13/24 (54%)
		ANK repeat	580..608	CDD:293786	17/27 (63%)
		ANK	614..734	CDD:238125	81/119 (68%)
		ANK repeat	614..645	CDD:293786	25/30 (83%)
		ANK repeat	647..678	CDD:293786	23/30 (77%)
		ANK	675..800	CDD:238125	72/124 (58%)
		ANK repeat	680..709	CDD:293786	14/28 (50%)
		ANK repeat	713..744	CDD:293786	19/30 (63%)
		ANK repeat	746..777	CDD:293786	18/30 (60%)
		ANK repeat	779..808	CDD:293786	17/28 (61%)
		Ank_4	780..832	CDD:316185	35/51 (69%)
		ZU5	1008..1145	CDD:128514	71/136 (52%)
		Neuromodulin_N	<1588..>1884	CDD:331332	72/350 (21%)
		DUF4045	<2885..3298	CDD:330572	95/514 (18%)
		Death_ank	3158..3241	CDD:260029	11/91 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	147	1.000	Domainoid score	I4446
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1011028at2759
OrthoFinder	1	1.000	-	-		FOG0000917
OrthoInspector	1	1.000	-	-		otm24809
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750