DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank2 and ANKRD65

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:NP_001138682.1 Gene:ANKRD65 / 441869 HGNCID:42950 Length:399 Species:Homo sapiens


Alignment Length:354 Identity:127/354 - (35%)
Similarity:166/354 - (46%) Gaps:45/354 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 AKW-GKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLH 309
            |.| |...:|:.||.:|.::|.:...|.||||.|...||..:|.:||:||||:.|..:.|     
Human    48 AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG----- 107

  Fly   310 MAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPL 374
                                        .||||.||..||.|||:|||.|.|.|.||:..|.|||
Human   108 ----------------------------RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPL 144

  Fly   375 H-IACKKNRLKVVELLLRHG---ASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVR 435
            | .|...:.|....||...|   |:..|....|.|..|.||..|.:.::..|....|..|     
Human   145 HWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD----- 204

  Fly   436 GETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTK 500
              ..|.:||.|.:...:|.||..||:||||.....|.|.:|:.||....:.:||.|||......:
Human   205 --GALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDR 267

  Fly   501 DMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQG 565
            ...:|||.||..|......:|:..||.:||....|.||||..::.||::||..||.:.|.|||.|
Human   268 HGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATG 332

  Fly   566 KNGVTPLHVACHYNNQQVALLLLEKGASP 594
            ....||||:|....:.....|||.:||||
Human   333 WLRKTPLHLAAERGHGPTVGLLLSRGASP 361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786
Ank_4 11..64 CDD:290365
ANK 38..163 CDD:238125
ANK repeat 43..74 CDD:293786
Ank_2 48..135 CDD:289560
ANK repeat 76..107 CDD:293786
ANK repeat 109..134 CDD:293786
Ank_4 110..163 CDD:290365
Ank_4 172..225 CDD:290365
ANK repeat 175..202 CDD:293786
ANK 199..324 CDD:238125 25/78 (32%)
ANK repeat 204..235 CDD:293786
Ank_2 209..300 CDD:289560 23/54 (43%)
ANK repeat 237..268 CDD:293786 8/22 (36%)
ANK 266..390 CDD:238125 44/124 (35%)
ANK repeat 270..300 CDD:293786 15/29 (52%)
ANK repeat 303..367 CDD:293786 19/63 (30%)
Ank_2 308..399 CDD:289560 30/94 (32%)
ANK 364..489 CDD:238125 41/128 (32%)
ANK repeat 369..400 CDD:293786 12/34 (35%)
ANK repeat 402..433 CDD:293786 9/30 (30%)
Ank_4 403..456 CDD:290365 14/52 (27%)
ANK repeat 435..466 CDD:293786 12/30 (40%)
Ank_2 440..530 CDD:289560 32/89 (36%)
ANK 463..588 CDD:238125 46/124 (37%)
ANK repeat 468..497 CDD:293786 10/28 (36%)
ANK repeat 501..530 CDD:293786 9/28 (32%)
Ank_2 506..597 CDD:289560 38/89 (43%)
ANK 529..654 CDD:238125 30/66 (45%)
ANK repeat 535..565 CDD:293786 15/29 (52%)
ANK repeat 567..598 CDD:293786 12/28 (43%)
Ank_2 572..661 CDD:289560 10/23 (43%)
ANK repeat 600..630 CDD:293786
ANK repeat 633..662 CDD:293786
ANK 661..785 CDD:238125
ANK repeat 666..697 CDD:293786
Ank_2 672..762 CDD:289560
ANK repeat 699..730 CDD:293786
ANK repeat 732..762 CDD:293786
ZU5 927..1030 CDD:128514
Death_ank 1417..1497 CDD:260029
ER-remodelling 11936..>12013 CDD:258892
ANKRD65NP_001138682.1 ANK 1 40..69 7/20 (35%)
ANK <41..94 CDD:238125 17/45 (38%)
Ank_2 45..136 CDD:289560 42/120 (35%)
ANK repeat 45..71 CDD:293786 8/22 (36%)
ANK 69..192 CDD:238125 54/155 (35%)
ANK 2 73..102 15/28 (54%)
ANK repeat 74..104 CDD:293786 16/29 (55%)
ANK repeat 106..137 CDD:293786 19/63 (30%)
ANK 3 106..135 18/61 (30%)
ANK 4 139..168 10/28 (36%)
Ank_2 144..299 CDD:289560 52/161 (32%)
ANK 5 176..205 9/35 (26%)
ANK 6 207..231 10/23 (43%)
ANK 7 235..264 10/28 (36%)
ANK 252..355 CDD:238125 38/102 (37%)
ANK repeat 268..299 CDD:293786 11/30 (37%)
ANK 8 268..297 9/28 (32%)
Ank_2 273..364 CDD:289560 38/89 (43%)
ANK repeat 301..332 CDD:293786 15/30 (50%)
ANK 9 301..330 13/28 (46%)
ANK repeat 334..364 CDD:293786 12/28 (43%)
ANK 10 334..363 12/28 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 377..399
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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