DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank2 and Tnni3k

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:NP_796040.3 Gene:Tnni3k / 435766 MGIID:2443276 Length:834 Species:Mus musculus


Alignment Length:488 Identity:133/488 - (27%)
Similarity:204/488 - (41%) Gaps:132/488 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   332 EVTVDY-----LTALHVAAHCG----HVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVE 387
            ||:::|     |:.||:...||    |:|.   |:.:....:....|||..||:|..|:.|:::.
Mouse    57 EVSLNYRTERGLSLLHLCCACGGNKSHIRA---LMLKGLRPSRLTRNGFPALHLAVYKDSLELIT 118

  Fly   388 LLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDII 452
            .||..||.:......|||.||:||..|....|..||||.|:.:|......||||:||......:.
Mouse   119 SLLHSGADVQQAGYGGLTALHIAAIAGHPEAVEVLLQHGANVNVQDAVFFTPLHIAAYYGHEQVT 183

  Fly   453 RILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEV 517
            .:||:.||.|:........|||:||..|..:||.||:: |.:.|           :.|::.:|.|
Mouse   184 SVLLKFGADVNVSGEVGDRPLHLASAKGFFNIVKLLVE-GNKAD-----------VNAQDNEDHV 236

  Fly   518 AAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKN--GVTPLHVACHYNN 580
                                |||..:::||..:...|||.:.:|.....|  |.||||:||:..|
Mouse   237 --------------------PLHFCSRFGHHNIVSYLLQSDLEVQPHVINIYGDTPLHLACYNGN 281

  Fly   581 QQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEG 645
            .:||..::      |.|.....|.                      .|..|:..|          
Mouse   282 FEVAKEIV------HVTGTESLTK----------------------ENIFSETAF---------- 308

  Fly   646 HAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAE-ILEKNGANIDMATKAGYTPLHVASH 709
                      |.|               |....|:::.: :|::|..||:...:.|:|.||.|.:
Mouse   309 ----------HSA---------------CTYGKNIDLVKFLLDQNAVNINHRGRDGHTGLHSACY 348

  Fly   710 FGQANMVRFLLQNGANV-----DAATSIG----YTPLHQTAQQGHCHIVNLLLEHKANANAQTVN 765
            .|...:|:|||.|||::     |.:.|.|    .|.|....::||..||.||..:|...:     
Mouse   349 HGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQD----- 408

  Fly   766 GQTPLHIARKLG----YISV---LDSLKTITKE 791
             :.|.:...:.|    |:||   |..:|::|||
Mouse   409 -ELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKE 440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786
Ank_4 11..64 CDD:290365
ANK 38..163 CDD:238125
ANK repeat 43..74 CDD:293786
Ank_2 48..135 CDD:289560
ANK repeat 76..107 CDD:293786
ANK repeat 109..134 CDD:293786
Ank_4 110..163 CDD:290365
Ank_4 172..225 CDD:290365
ANK repeat 175..202 CDD:293786
ANK 199..324 CDD:238125
ANK repeat 204..235 CDD:293786
Ank_2 209..300 CDD:289560
ANK repeat 237..268 CDD:293786
ANK 266..390 CDD:238125 19/66 (29%)
ANK repeat 270..300 CDD:293786
ANK repeat 303..367 CDD:293786 11/43 (26%)
Ank_2 308..399 CDD:289560 23/75 (31%)
ANK 364..489 CDD:238125 47/124 (38%)
ANK repeat 369..400 CDD:293786 12/30 (40%)
ANK repeat 402..433 CDD:293786 15/30 (50%)
Ank_4 403..456 CDD:290365 21/52 (40%)
ANK repeat 435..466 CDD:293786 11/30 (37%)
Ank_2 440..530 CDD:289560 24/89 (27%)
ANK 463..588 CDD:238125 35/126 (28%)
ANK repeat 468..497 CDD:293786 11/28 (39%)
ANK repeat 501..530 CDD:293786 3/28 (11%)
Ank_2 506..597 CDD:289560 24/92 (26%)
ANK 529..654 CDD:238125 26/126 (21%)
ANK repeat 535..565 CDD:293786 9/29 (31%)
ANK repeat 567..598 CDD:293786 12/32 (38%)
Ank_2 572..661 CDD:289560 15/88 (17%)
ANK repeat 600..630 CDD:293786 2/29 (7%)
ANK repeat 633..662 CDD:293786 3/28 (11%)
ANK 661..785 CDD:238125 37/140 (26%)
ANK repeat 666..697 CDD:293786 6/31 (19%)
Ank_2 672..762 CDD:289560 31/99 (31%)
ANK repeat 699..730 CDD:293786 14/35 (40%)
ANK repeat 732..762 CDD:293786 10/33 (30%)
ZU5 927..1030 CDD:128514
Death_ank 1417..1497 CDD:260029
ER-remodelling 11936..>12013 CDD:258892
Tnni3kNP_796040.3 ANK repeat 66..98 CDD:293786 8/34 (24%)
ANK 1 66..96 8/32 (25%)
Ank_2 71..164 CDD:289560 34/95 (36%)
ANK 99..220 CDD:238125 47/120 (39%)
ANK repeat 100..131 CDD:293786 12/30 (40%)
ANK 2 100..129 12/28 (43%)
ANK 3 133..162 14/28 (50%)
ANK repeat 134..164 CDD:293786 15/29 (52%)
Ank_2 138..231 CDD:289560 36/104 (35%)
ANK 161..289 CDD:238125 47/159 (30%)
ANK repeat 166..197 CDD:293786 11/30 (37%)
ANK 4 166..195 11/28 (39%)
ANK repeat 199..231 CDD:293786 13/43 (30%)
ANK 5 199..229 12/41 (29%)
ANK 228..359 CDD:238125 45/213 (21%)
ANK 6 233..262 11/48 (23%)
Ank_4 237..286 CDD:290365 19/48 (40%)
ANK repeat 268..301 CDD:293786 13/60 (22%)
ANK 7 268..297 12/34 (35%)
Ank_2 273..368 CDD:289560 34/157 (22%)
ANK repeat 303..336 CDD:293786 10/67 (15%)
ANK 8 303..334 10/65 (15%)
ANK 333..>400 CDD:238125 22/66 (33%)
ANK repeat 338..368 CDD:293786 13/29 (45%)
ANK 9 338..367 13/28 (46%)
Ank_4 339..400 CDD:290365 22/60 (37%)
ANK 10 380..409 9/34 (26%)
TyrKc 462..718 CDD:197581
PKc_TNNI3K 468..721 CDD:270966
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 815..834
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D53364at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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