DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and CG10011

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	NP_651624.2	Gene:	CG10011 / 43387	FlyBaseID:	FBgn0039590	Length:	2119	Species:	Drosophila melanogaster

Alignment Length:	1055	Identity:	266/1055 - (25%)
Similarity:	408/1055 - (38%)	Gaps:	300/1055 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTA 80
            :...|||:..   ||.:...:....||:  :.||..|...||.:               .||...
  Fly  1194 METQRAGSPS---EHSEPPAESQDENAS--STLHQLSDSHHIEL---------------HKGKAL 1238

  Fly    81 LHIASLAGQEEVVKLLLEHNA-----SVNVQSQNGFTPLYMAAQENHDAVVRLLLS------NGA 134
            :||.:..|..::::..|  ||     .:.::..||.|.|.:||:..|..||:||||      :|.
  Fly  1239 IHILANDGNHQLLERAL--NACKSPIDLEIEDYNGQTALNIAARNGHLEVVKLLLSFSQPCNDGT 1301

  Fly   135 NQ------SLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLD 193
            .:      :.|..||:|||..|...||.:||.:|:..        ||..|
  Fly  1302 GRMKRVDVNHADRDGWTPLRSASWGGHSEVVRLLIAQ--------PACKI--------------- 1343

  Fly   194 NDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLL 258
                 |:..|.|.|.|..|:..|:::|..|||:.|||||
  Fly  1344 -----DLADKEGRTALRAAAWSGHEDILKLLIESGADVN-------------------------- 1377

  Fly   259 EKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARIL 323
                   :..|.|.|.|..|:..||..:|::|||.||.::                 |:|
  Fly  1378 -------SVDRQGRTSLIAASYMGHYDIVEILLENGANVN-----------------HLD----- 1413

  Fly   324 LYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVEL 388
                       :|..:||.|||.||.                   :|::           ||:..
  Fly  1414 -----------LDGRSALCVAALCGS-------------------SGYS-----------KVIST 1437

  Fly   389 LLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIR 453
            ||.|||:.......|::||.|::|.|...:...||::.|.||:....|.|||..|..|....:::
  Fly  1438 LLDHGANTDQLDNDGMSPLLVSSFEGNAEVCELLLENAADPDLADFMGRTPLWAACTAGHATVVK 1502

  Fly   454 ILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDM--YTALHIAAKEGQDE 516
            :||..|..:|....|.:|.|.|.:..|||:.|..||..|  :|.|.:|.  :|.||.||.||..|
  Fly  1503 LLLFWGCGIDCMDSEGRTVLSIGAAQGNVETVRQLLDRG--LDETHRDNAGWTPLHYAAFEGFHE 1565

  Fly   517 VAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEAD-VDAQGKNGVTPLHVACHYNN 580
            |...|:|:||.:|....:|.|.|||.|:.|.:...|.||...:. ||.:..:|.|...:||...:
  Fly  1566 VCLQLLESGAKIDECDNEGKTALHLAAQEGRLHCVQALLDIHSSFVDQKAHDGKTAFRLACLEGH 1630

  Fly   581 QQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGAL-ANAESKAGFTPLHLSSQE 644
            ......||:.....::...:..|.|:|.|.:|:::|...||:...: .|.....|.|.||:::.:
  Fly  1631 MDTVEFLLKFCCDVNSKDADSRTTLYILALENKLEIVKYLLDMTNVDVNIPDSEGRTALHVAAWQ 1695

  Fly   645 GHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASH 709
            |||::...|||..|.||.......||:|.||.:.|.:|..||...||..|.|.|.|.|.|.:::.
  Fly  1696 GHADMVKTLIEAGADVNSMDLEARTPLHSCAWQGNHDVMNILLYYGALADHACKQGATALGISAQ 1760

  Fly   710 FGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIAR 774
            .|....|..|||.|||              ..:..||                   |:||:.:|.
  Fly  1761 EGHEKCVIALLQFGAN--------------PYKSDHC-------------------GRTPIKLAA 1792

  Fly   775 KLGYISVLDSLKTITKEDETAAAPSQAEEKYRV-------------------VAPEAMHESFMS- 819
            |....|:|...::.||.:  |:.|:  |.|:..                   :||...|.|..|
  Fly  1793 KSSRTSILKIFESYTKNE--ASNPN--EPKFHAHASMLRSPDQPPALPLHQNLAPYPAHASASSV 1853

  Fly   820 ------------------------DSEEEGGEDNMLSDQP--YRYLTVDEMKSLG--DDSLPIDV 856
                                    .|.....::.|.||..  ::..:|...:|.|  :|..|:..
  Fly  1854 CSAATTATVHNGSHLHVLNASSSTHSSNNFYQNTMQSDTSSLHKRKSVISSQSTGSSNDQAPLTF 1918

  Fly   857 T----RDERMDS-NRMTQSAEYASG--------------------VPPTIGEEVISPHKTQVYGS 896
            |    |..::.| |.:..::::||.                    |.|.:.|..::.:.|.....
  Fly  1919 TQQLQRQSKLSSRNNLMVNSKHASSSGAAGHKSSGGGGGAQRHSQVLPDLSEHQLASNMTNEADM 1983

  Fly   897 SPKATVDGVYIANGSGHDEPPH-VGRKLSWKSFLV---SFLVDARGGAMRG----------CRHS 947
            .....:..:|..       ||| ...:||....|.   :|:.|.|.|...|          .|.:
  Fly  1984 YDMECMSPLYAT-------PPHSPSSELSSPGQLPGLNAFVDDERAGTSSGGGAKLPDNHFARDT 2041

  Fly   948 GVRMIIPSRSTCQPT 962
            .:|:|:.:....||:
  Fly  2042 HMRIILGNLKENQPS 2056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	5/24 (21%)
		Ank_4	11..64	CDD:290365	12/47 (26%)
		ANK	38..163	CDD:238125	40/141 (28%)
		ANK repeat	43..74	CDD:293786	5/30 (17%)
		Ank_2	48..135	CDD:289560	27/97 (28%)
		ANK repeat	76..107	CDD:293786	8/35 (23%)
		ANK repeat	109..134	CDD:293786	13/30 (43%)
		Ank_4	110..163	CDD:290365	24/64 (38%)
		Ank_4	172..225	CDD:290365	12/52 (23%)
		ANK repeat	175..202	CDD:293786	3/26 (12%)
		ANK	199..324	CDD:238125	31/124 (25%)
		ANK repeat	204..235	CDD:293786	14/30 (47%)
		Ank_2	209..300	CDD:289560	25/90 (28%)
		ANK repeat	237..268	CDD:293786	0/30 (0%)
		ANK	266..390	CDD:238125	26/123 (21%)
		ANK repeat	270..300	CDD:293786	12/29 (41%)
		ANK repeat	303..367	CDD:293786	10/63 (16%)
		Ank_2	308..399	CDD:289560	18/90 (20%)
		ANK	364..489	CDD:238125	37/124 (30%)
		ANK repeat	369..400	CDD:293786	8/30 (27%)
		ANK repeat	402..433	CDD:293786	11/30 (37%)
		Ank_4	403..456	CDD:290365	17/52 (33%)
		ANK repeat	435..466	CDD:293786	10/30 (33%)
		Ank_2	440..530	CDD:289560	34/91 (37%)
		ANK	463..588	CDD:238125	45/127 (35%)
		ANK repeat	468..497	CDD:293786	11/28 (39%)
		ANK repeat	501..530	CDD:293786	14/30 (47%)
		Ank_2	506..597	CDD:289560	31/91 (34%)
		ANK	529..654	CDD:238125	35/126 (28%)
		ANK repeat	535..565	CDD:293786	12/30 (40%)
		ANK repeat	567..598	CDD:293786	6/30 (20%)
		Ank_2	572..661	CDD:289560	24/89 (27%)
		ANK repeat	600..630	CDD:293786	9/30 (30%)
		ANK repeat	633..662	CDD:293786	12/28 (43%)
		ANK	661..785	CDD:238125	35/123 (28%)
		ANK repeat	666..697	CDD:293786	12/30 (40%)
		Ank_2	672..762	CDD:289560	25/89 (28%)
		ANK repeat	699..730	CDD:293786	11/30 (37%)
		ANK repeat	732..762	CDD:293786	2/29 (7%)
		ZU5	927..1030	CDD:128514	11/49 (22%)
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
CG10011	NP_651624.2	AAA	344..457	CDD:214640
		Methylase_S	<772..885	CDD:279728
		Ank_4	1237..1291	CDD:290365	16/55 (29%)
		ANK	1266..1403	CDD:238125	53/197 (27%)
		ANK repeat	1270..1313	CDD:293786	14/42 (33%)
		Ank_2	1275..1380	CDD:289560	42/165 (25%)
		ANK repeat	1315..1347	CDD:293786	15/59 (25%)
		ANK repeat	1349..1380	CDD:293786	14/63 (22%)
		Ank_2	1354..1449	CDD:289560	43/190 (23%)
		ANK repeat	1382..1413	CDD:293786	13/47 (28%)
		ANK	1410..1538	CDD:238125	47/190 (25%)
		ANK repeat	1415..1446	CDD:293786	16/60 (27%)
		Ank_5	1438..1489	CDD:290568	18/50 (36%)
		ANK	1479..1604	CDD:238125	47/126 (37%)
		ANK repeat	1484..1515	CDD:293786	10/30 (33%)
		Ank_2	1489..1581	CDD:289560	35/93 (38%)
		ANK repeat	1517..1548	CDD:293786	13/32 (41%)
		ANK repeat	1550..1581	CDD:293786	14/30 (47%)
		Ank_2	1555..1648	CDD:289560	31/92 (34%)
		ANK	1578..1705	CDD:238125	35/126 (28%)
		ANK repeat	1617..1648	CDD:293786	6/30 (20%)
		Ank_2	1624..1715	CDD:289560	26/90 (29%)
		ANK	1645..1771	CDD:238125	41/125 (33%)
		ANK repeat	1650..1682	CDD:293786	9/31 (29%)
		ANK repeat	1684..1715	CDD:293786	13/30 (43%)
		Ank_2	1689..1781	CDD:289560	36/105 (34%)
		ANK repeat	1717..1742	CDD:293786	9/24 (38%)
		ANK repeat	1750..1775	CDD:293786	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3248
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	1	1.100	-	-	P	PTHR24123
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.910