DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ank2 and Tnks

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster


Alignment Length:1378 Identity:340/1378 - (24%)
Similarity:542/1378 - (39%) Gaps:291/1378 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 NTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAI--VDSAT 74
            |:|..||..:.||:.|:.:            :.|..|..|.|.|.|..|.:|:....:  .|:|.
  Fly     3 NSSRSRAILSVNLDAVMAN------------DPLRELFEACKTGEIAKVKKLITPQTVNARDTAG 55

  Fly    75 KKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLA 139
            :| :|.||.|:..|:.|||:.||...||:....:.|..||:......|..||||||..||:.:..
  Fly    56 RK-STPLHFAAGYGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTT 119

  Fly   140 TEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKS 204
            ....:|||..|..:|...|...||:......:|         ..:.|....|.|....|.:|.:.
  Fly   120 DNWNYTPLHEAASKGKVDVCLALLQHGANHTIR---------NSEQKTPLELADEATRPVLTGEY 175

  Fly   205 GFTPLHIASHYGNQN-IANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKT 268
            ....|..|:..|.:: :..||.....:.:.|.....:|||:||.:.:..:|.:||..|.::.||.
  Fly   176 RKDELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKD 240

  Fly   269 RDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILL--------- 324
            :.||.|||.|...||..|..:|::.||.::|.......|||.||....|:...:||         
  Fly   241 KGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLL 305

  Fly   325 --YHRAPVDEVTVDYL---TALHVAAHCGHVRVAKLLLD--RNADAN-------ARALN------ 369
              :.::.:|......|   .|.....||        |||  |..|.:       |..:|      
  Fly   306 NCHSKSAIDAAPTRELRERIAFEYKGHC--------LLDACRKCDVSRAKKLVCAEIVNFVHPYT 362

  Fly   370 GFTPLHIACKK---NRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDV 431
            |.||||:|...   .|.:::|||.|.|:.::...::.|||||:||.:...:.:..||:..|..:.
  Fly   363 GDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNA 427

  Fly   432 PTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVD 496
            ....|:||||..||..|.  :|:||...|..:..:.|..|...:||     |.|:.||::     
  Fly   428 LDSLGQTPLHRCARDEQA--VRLLLSYAADTNIVSLEGLTAAQLAS-----DSVLKLLKN----- 480

  Fly   497 ATTKDMYTALHIAAKEGQ-DEVAAVLIENGAALDAATKKG--FTPLHLTAKYGHIKVAQLLLQKE 558
              ..|..|.|..|||.|. |.|..:::.|..:::.....|  .||||..|.:..:.|.|.||:..
  Fly   481 --PPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHG 543

  Fly   559 ADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEY 623
            |:|.|..|.|:.|||.||.|.:.:|..||::.||:.:.:.....||||.||.|.:.||...||::
  Fly   544 AEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKH 608

  Fly   624 GALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGL-------------------- 668
            ||....:::.|.||..|..:..| :::.||....|.::...|..|                    
  Fly   609 GADPMKKNRDGATPADLVKESDH-DVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGR 672

  Fly   669 --TPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATS 731
              ||:||.|..:|...||.|.:|||:::...|.|..|||.||.:|..::...|:::...|:|...
  Fly   673 NSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDK 737

  Fly   732 IGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHI--------------ARKLGYISVL 782
            .|:||||:.||:|...:.:|||.|.|:|..:...||||:.:              |..|...::.
  Fly   738 WGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKCLLQDAMATSLSQQALS 802

  Fly   783 DSLKTITKE----DETAAA----------------------PSQAEEKYRVVAPEAMHESFMSDS 821
            .|.:::|..    |.||||                      |:.|.....|..|..:..| ...|
  Fly   803 ASTQSLTSSSPAPDATAAAAPGTSSSSSSAILSPTTETVLLPTGASMILSVPVPLPLSSS-TRIS 866

  Fly   822 EEEGGEDNMLSDQPYRYLTVDEMKSLGDDSLPIDVTRDERMDSNRMTQSAEYASG---------- 876
            ..:|.|.|....            |..||.||         |::.:|..:.:.|.          
  Fly   867 PAQGAEANGAEG------------SSSDDLLP---------DADTITNVSGFLSSQQLHHLIELF 910

  Fly   877 --------VPPTIGEEVISPHKTQVYGSSPKATVDGVYIANGSGHDEPPHVGRKLSWKSFLVSFL 933
                    :...:|.:.:.......||...|.......:.:.:|      :|..::..:.||..|
  Fly   911 EREQITLDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLRSTTG------IGNNVNLCTLLVDLL 969

  Fly   934 VDAR---------GGAMRGCRHSG------VRMIIPSRSTCQPTRVTCRYVKPQRTM-------- 975
            .|.:         ...:|..|.:|      .|..|......|..::..||...::.:        
  Fly   970 PDDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRRQEIAEENFLQS 1034

  Fly   976 HPPQLMEGEALASRVLELG-PCSTKFIGPVVMEVPHFASLRGKE--------------------- 1018
            :...|..|....:.:::.| .....:||.:.....:||....|.                     
  Fly  1035 NERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSHKDKSC 1099

  Fly  1019 ----REIIILRSDNGETWREHTIDNSEEIIHDVLQQCFEP---EEIAQLEEQAGNHVCRFVTY-- 1074
                |::::.|...|:::.:::          .::....|   ..:.......|.|...:|.|  
  Fly  1100 YVCPRQLLLCRVALGKSFLQYS----------AMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRG 1154

  Fly  1075 --DFPQYFAVVSRIRQEVHAIG--------PEGGMVSSTVVP------------QVQAVFPQGAL 1117
              .:|:|......::.:..:.|        |..|...:|..|            |.|...||...
  Fly  1155 EQSYPEYLITYQIVKPDDSSSGTEDTRXWMPSVGSTPTTTSPALHQPQTQQQPQQQQQQQPQPQQ 1219

  Fly  1118 TKKIKVGL---QAQPVDPDLTAKLLGRGVAVSPIVTVEPRRRKFH------KAITLSMPAPK--- 1170
            .:|..:.|   |.|...|  .||...:....|..:..:|.:.:.|      .|:|.:.|:|.   
  Fly  1220 QQKAPLPLPPPQQQTSAP--VAKRRPKHAKPSLQLQYQPYQPQHHPVVATAAAVTTTQPSPAGVF 1282

  Fly  1171 AHSQGMINQYSGN 1183
            |||....|..|||
  Fly  1283 AHSNNNNNTSSGN 1295

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786 7/28 (25%)
Ank_4 11..64 CDD:290365 14/51 (27%)
ANK 38..163 CDD:238125 41/126 (33%)
ANK repeat 43..74 CDD:293786 9/32 (28%)
Ank_2 48..135 CDD:289560 33/88 (38%)
ANK repeat 76..107 CDD:293786 13/30 (43%)
ANK repeat 109..134 CDD:293786 10/24 (42%)
Ank_4 110..163 CDD:290365 18/52 (35%)
Ank_4 172..225 CDD:290365 10/53 (19%)
ANK repeat 175..202 CDD:293786 4/26 (15%)
ANK 199..324 CDD:238125 37/125 (30%)
ANK repeat 204..235 CDD:293786 5/31 (16%)
Ank_2 209..300 CDD:289560 29/91 (32%)
ANK repeat 237..268 CDD:293786 10/30 (33%)
ANK 266..390 CDD:238125 44/155 (28%)
ANK repeat 270..300 CDD:293786 12/29 (41%)
ANK repeat 303..367 CDD:293786 19/86 (22%)
Ank_2 308..399 CDD:289560 31/122 (25%)
ANK 364..489 CDD:238125 42/140 (30%)
ANK repeat 369..400 CDD:293786 13/39 (33%)
ANK repeat 402..433 CDD:293786 10/30 (33%)
Ank_4 403..456 CDD:290365 19/52 (37%)
ANK repeat 435..466 CDD:293786 12/30 (40%)
Ank_2 440..530 CDD:289560 27/90 (30%)
ANK 463..588 CDD:238125 41/127 (32%)
ANK repeat 468..497 CDD:293786 8/28 (29%)
ANK repeat 501..530 CDD:293786 10/29 (34%)
Ank_2 506..597 CDD:289560 34/93 (37%)
ANK 529..654 CDD:238125 45/126 (36%)
ANK repeat 535..565 CDD:293786 13/31 (42%)
ANK repeat 567..598 CDD:293786 12/30 (40%)
Ank_2 572..661 CDD:289560 31/88 (35%)
ANK repeat 600..630 CDD:293786 13/29 (45%)
ANK repeat 633..662 CDD:293786 8/28 (29%)
ANK 661..785 CDD:238125 45/159 (28%)
ANK repeat 666..697 CDD:293786 13/52 (25%)
Ank_2 672..762 CDD:289560 35/89 (39%)
ANK repeat 699..730 CDD:293786 10/30 (33%)
ANK repeat 732..762 CDD:293786 14/29 (48%)
ZU5 927..1030 CDD:128514 22/151 (15%)
Death_ank 1417..1497 CDD:260029
ER-remodelling 11936..>12013 CDD:258892
TnksNP_001262963.1 ANK 49..163 CDD:238125 37/123 (30%)
ANK repeat 59..87 CDD:293786 12/27 (44%)
Ank_2 61..153 CDD:289560 32/100 (32%)
ANK repeat 89..120 CDD:293786 12/30 (40%)
ANK repeat 122..153 CDD:293786 9/39 (23%)
ANK 202..316 CDD:238125 34/113 (30%)
ANK repeat 212..240 CDD:293786 10/27 (37%)
Ank_2 214..306 CDD:289560 31/91 (34%)
ANK repeat 242..273 CDD:293786 13/30 (43%)
ANK repeat 275..306 CDD:293786 8/30 (27%)
ANK 361..478 CDD:238125 40/123 (33%)
ANK repeat 363..396 CDD:293786 12/32 (38%)
Ank_2 367..459 CDD:289560 31/93 (33%)
ANK 393..573 CDD:238125 63/193 (33%)
ANK repeat 398..429 CDD:293786 10/30 (33%)
ANK repeat 431..459 CDD:293786 12/29 (41%)
ANK repeat 483..515 CDD:293786 10/31 (32%)
Ank_4 486..540 CDD:290365 17/53 (32%)
ANK 512..637 CDD:238125 44/125 (35%)
ANK repeat 522..550 CDD:293786 12/27 (44%)
Ank_2 524..616 CDD:289560 36/91 (40%)
ANK repeat 552..583 CDD:293786 12/30 (40%)
ANK repeat 585..610 CDD:293786 11/24 (46%)
ANK repeat 638..668 CDD:293786 3/29 (10%)
Ank_4 641..693 CDD:290365 11/51 (22%)
ANK 665..779 CDD:238125 41/113 (36%)
ANK repeat 672..703 CDD:293786 12/30 (40%)
Ank_2 677..769 CDD:289560 35/91 (38%)
ANK repeat 705..736 CDD:293786 10/30 (33%)
ANK repeat 738..769 CDD:293786 14/30 (47%)
SAM_tankyrase1,2 887..952 CDD:188923 7/64 (11%)
SAM 890..952 CDD:197735 6/61 (10%)
tankyrase_like 948..1170 CDD:238718 32/237 (14%)
PARP 961..1165 CDD:279038 30/213 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm3248
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.810

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