DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank2 and ANKDD1A

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:NP_874362.3 Gene:ANKDD1A / 348094 HGNCID:28002 Length:522 Species:Homo sapiens


Alignment Length:369 Identity:113/369 - (30%)
Similarity:182/369 - (49%) Gaps:16/369 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   270 DGLTP----LHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPV 330
            |||.|    ||.|||..:...:..|:.|.....|:...|...||.||...|..|.|:||.|.|.|
Human    10 DGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAV 74

  Fly   331 DEV-TVDYLT---------ALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKV 385
            ||. .|..||         ||.::|..||:|:.::|::..|..:..:.:|.|.||.|.:|..:.|
Human    75 DEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPV 139

  Fly   386 VELLLR--HGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQ 448
            :..::.  ...::....:.|.|..|.||..|.::.:.:|:......:|....|.|.|||||....
Human   140 LAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGH 204

  Fly   449 TDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEG 513
            ..:::.|:..|..::.:..|..|.||.|:...:.|.|.|||:.|:.|:|.|:...:.||.||..|
Human   205 MAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSG 269

  Fly   514 QDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHY 578
            .::|:.|||..|...:....:|.:||||..::....:.:||:..::||:|......||||:|..:
Human   270 SEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEH 334

  Fly   579 NNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLE 622
            ..|.:|.:||..|...:...|.|.|.|.:|.|.|.:.:...:::
Human   335 AWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIK 378

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786
Ank_4 11..64 CDD:290365
ANK 38..163 CDD:238125
ANK repeat 43..74 CDD:293786
Ank_2 48..135 CDD:289560
ANK repeat 76..107 CDD:293786
ANK repeat 109..134 CDD:293786
Ank_4 110..163 CDD:290365
Ank_4 172..225 CDD:290365
ANK repeat 175..202 CDD:293786
ANK 199..324 CDD:238125 20/57 (35%)
ANK repeat 204..235 CDD:293786
Ank_2 209..300 CDD:289560 11/33 (33%)
ANK repeat 237..268 CDD:293786
ANK 266..390 CDD:238125 45/133 (34%)
ANK repeat 270..300 CDD:293786 11/33 (33%)
ANK repeat 303..367 CDD:293786 26/73 (36%)
Ank_2 308..399 CDD:289560 32/102 (31%)
ANK 364..489 CDD:238125 32/126 (25%)
ANK repeat 369..400 CDD:293786 7/32 (22%)
ANK repeat 402..433 CDD:293786 8/30 (27%)
Ank_4 403..456 CDD:290365 15/52 (29%)
ANK repeat 435..466 CDD:293786 9/30 (30%)
Ank_2 440..530 CDD:289560 31/89 (35%)
ANK 463..588 CDD:238125 41/124 (33%)
ANK repeat 468..497 CDD:293786 12/28 (43%)
ANK repeat 501..530 CDD:293786 10/28 (36%)
Ank_2 506..597 CDD:289560 30/90 (33%)
ANK 529..654 CDD:238125 27/94 (29%)
ANK repeat 535..565 CDD:293786 10/29 (34%)
ANK repeat 567..598 CDD:293786 10/30 (33%)
Ank_2 572..661 CDD:289560 15/51 (29%)
ANK repeat 600..630 CDD:293786 6/23 (26%)
ANK repeat 633..662 CDD:293786
ANK 661..785 CDD:238125
ANK repeat 666..697 CDD:293786
Ank_2 672..762 CDD:289560
ANK repeat 699..730 CDD:293786
ANK repeat 732..762 CDD:293786
ZU5 927..1030 CDD:128514
Death_ank 1417..1497 CDD:260029
ER-remodelling 11936..>12013 CDD:258892
ANKDD1ANP_874362.3 ANK 1 14..43 8/28 (29%)
Ank_2 19..118 CDD:289560 34/98 (35%)
ANK repeat 19..45 CDD:293786 8/25 (32%)
ANK 43..179 CDD:238125 40/135 (30%)
ANK 2 47..76 13/28 (46%)
ANK repeat 48..78 CDD:293786 15/29 (52%)
ANK repeat 90..121 CDD:293786 8/30 (27%)
ANK 3 90..119 8/28 (29%)
Ank_2 95..189 CDD:289560 22/93 (24%)
ANK 122..245 CDD:238125 32/122 (26%)
ANK repeat 123..156 CDD:293786 7/32 (22%)
ANK 4 123..152 7/28 (25%)
ANK 5 158..187 7/28 (25%)
ANK repeat 159..189 CDD:293786 8/29 (28%)
Ank_2 163..253 CDD:289560 27/89 (30%)
ANK 186..311 CDD:238125 40/124 (32%)
ANK repeat 191..222 CDD:293786 9/30 (30%)
ANK 6 191..220 9/28 (32%)
ANK repeat 224..253 CDD:293786 12/28 (43%)
ANK 7 224..253 12/28 (43%)
ANK 252..377 CDD:238125 39/124 (31%)
ANK 8 257..286 10/28 (36%)
ANK repeat 260..288 CDD:293786 10/27 (37%)
Ank_2 262..354 CDD:289560 30/91 (33%)
ANK repeat 290..321 CDD:293786 10/30 (33%)
ANK 9 290..319 9/28 (32%)
ANK repeat 323..354 CDD:293786 10/30 (33%)
ANK 10 323..352 10/28 (36%)
ANK 11 356..385 6/23 (26%)
Death 426..494 CDD:260017
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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